Physician

Neurology

Michael Schlossmacher is an expert in the field of Neurology. Michael G. Schlossmacher is a published doctor. He published 50 publications, including: 'The life of Eugene Braunwald: a remarkable journey that began in Vienna.'

Publications

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• Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.
• Parkin-Dependent Degradation of the F-box protein Fbw7β Promotes Neuronal Survival in response to oxidative stress by Stabilizing Mcl-1.
• Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
• CNS expression of glucocerebrosidase corrects {alpha}-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy.
• Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing.
• Translational Research in Neurology and Neuroscience 2011: Movement Disorders.
• Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration.
• Multiple system atrophy: a primary oligodendrogliopathy.
• GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.
• Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder.
• Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
• Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
• Molecular markers of early Parkinson's disease based on gene expression in blood.
• Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.
• Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
• Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.
• Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.
• Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition.
• Dopamine covalently modifies and functionally inactivates parkin.
• Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers.
• The glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews.
• Parkinson's disease: assays for the ubiquitin ligase activity of neural Parkin.
• Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain.
• Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-2004. A 79-year-old woman with disturbances in gait, cognition, and a...
• Seizures after epidural blood patch.
• Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
• Parkinson''s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
• Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
• Increased DJ-1 expression under oxidative stress and in Alzheimer''s disease brains.
• Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.
• CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies.
• Biomarker research in Parkinson''s disease: objective measures needed for patient stratification in future cause-directed trials.
• Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies.
• α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.
• The effects of oxidative stress on parkin and other E3 ligases.
• RING finger 1 mutations in Parkin produce altered localization of the protein.
• Deciphering the role of heterozygous mutations in genes associated with parkinsonism.
• Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies.
• The genetics of Parkinson disease: Implications for neurological care.
• Amyloid beta-peptide is produced by cultured cells during normal metabolism.
• Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
• Detection of soluble forms of the beta-amyloid precursor protein in human plasma.
• Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
• beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
• The life of Eugene Braunwald: a remarkable journey that began in Vienna.
• Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.
• Isolation and quantification of soluble Alzheimer''s beta-peptide from biological fluids.
• Hashimoto''s encephalopathy mimicking Creutzfeldt-Jakob disease: brain biopsy findings.
• Vertebral artery dissection with a normal-appearing lumen at multisection CT angiography: the importance of identifying wall hematoma.

Schools

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• University of Vienna

• Harvard Med School

• Harvard Med SchMa Genl HospBrigham and Womens Hospital

Doctors Specialties

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• Neurology

Accepted Insurances

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Education

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• Beth Israel Deaconess Medical Center

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