Oberndorf Family Distinguished Professor, Chairman, Department of Psychiatry, and Director, Langley Porter Psychiatric Institute, University of California, San Francisco

Psychiatry

Matthew State practices Psychiatry. He went to Yale University School of Medicine. Yale University School of Medicine is a top medical university. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He received 2 awards: "Member" and "Ruane Prize for Research in Child and Adolescent Psychiatry". Matthew State is also published. He has 99 publications published. The lastest publication: "Cerebrospinal fluid levels of oxytocin in Prader-Willi syndrome: a preliminary report.'

Publications

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• Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2.
• Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.
• Gene hunting in autism spectrum disorder: on the path to precision medicine.
• Loss of δ-catenin function in severe autism.
• No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Protein...
• Leveraging genetics and genomics to define the causes of mental illness.
• Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons.
• Autism spectrum disorders: from genes to neurobiology.
• The contribution of de novo coding mutations to autism spectrum disorder.
• Synaptic, transcriptional and chromatin genes disrupted in autism.
• De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.
• The Inheritance of Tourette Disorder: A review.
• A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?
• Psychiatric Disorders: Diagnosis to Therapy.
• Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.
• Neuroscience. The emerging biology of autism spectrum disorders.
• De novo mutations revealed by whole-exome sequencing are strongly associated with autism.
• L-histidine decarboxylase and Tourette's syndrome.
• Modest Impact on Risk for Autism Spectrum Disorder of Rare Copy Number Variants at 15q11.2, Specifically Breakpoints 1 to 2.
• Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.
• The developmental transcriptome of the human brain: implications for neurodevelopmental disorders.
• DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics.
• Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders.
• Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder.
• Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.
• Mutations in DSTYK and dominant urinary tract malformations.
• Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes.
• Recent developments in the genetics of autism spectrum disorders.
• Intellectual Disability Is Associated with Increased Runs of Homozygosity in Simplex Autism.
• Adjusting Head Circumference for Covariates in Autism: Clinical Correlates of a Highly Heritable Continuous Trait.
• High rate of disease-related copy number variations in childhood onset schizophrenia.
• Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO.
• Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders.
• Using Whole-Exome Sequencing to Identify Inherited Causes of Autism.
• The Autism Sequencing Consortium: Large-Scale, High-Throughput Sequencing in Autism Spectrum Disorders.
• Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy.
• Common genetic variants, acting additively, are a major source of risk for autism.
• Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts.
• Genome-wide Transcriptome Profiling Reveals the Functional Impact of Rare De Novo and Recurrent CNVs in Autism Spectrum Disorders.
• A complex chromosomal rearrangement involving chromosomes 2, 5, and X in autism spectrum disorder.
• Searching for Potocki-Lupski syndrome phenotype: A patient with language impairment and no autism.
• Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism.
• The conundrums of understanding genetic risks for autism spectrum disorders.
• Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.
• Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism.
• The erosion of phenotypic specificity in psychiatric genetics: emerging lessons from CNTNAP2.
• The genetics of Tourette disorder.
• The genetics of child psychiatric disorders: focus on autism and Tourette syndrome.
• Progress in cytogenetics: implications for child psychopathology.
• Novel VLDLR microdeletion identified in two Turkish siblings with pachygyria and pontocerebellar atrophy.
• Another piece of the autism puzzle.
• Genome-wide association study of intracranial aneurysm identifies three new risk loci.
• A patient with Duchenne muscular dystrophy and autism demonstrates a hemizygous deletion affecting Dystrophin.
• The genetics of autism: key issues, recent findings, and clinical implications.
• The syndrome of pachygyria, mental retardation, and arachnoid cysts maps to 11p15.
• Functional and evolutionary insights into human brain development through global transcriptome analysis.
• Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome.
• Susceptibility loci for intracranial aneurysm in European and Japanese populations.
• Molecular characterization of a patient with 3p deletion syndrome and a review of the literature.
• Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome.
• Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
• Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population.
• Autism genetics: strategies, challenges, and opportunities.
• Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.
• Rapid identification of disease-causing mutations using copy number analysis within linkage intervals.
• Recent advances in the genetics of autism.
• A surprising METamorphosis: autism genetics finds a common functional variant.
• A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.
• Sequence variants in SLITRK1 are associated with Tourette's syndrome.
• Rapid array-based genomic characterization of a subtle structural abnormality: a patient with psychosis and der(18)t(5;18)(p14.1;p11.23).
• Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder.
• Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22.
• Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome.
• Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype.
• The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment.
• Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.
• High levels of histidine decarboxylase in the striatum of mice and rats.
• A novel heterozygous deletion within the 3'' region of the PAX6 gene causing isolated aniridia in a large family group.
• Common genetic variants on 5p14.1 associate with autism spectrum disorders.
• [Autism: genetics].
• Mapping a Mendelian form of intracranial aneurysm to 1p34.3-p36.13.
• Electrocardiographic changes in children and adolescents treated with ziprasidone: a prospective study.
• Autism and autism spectrum disorders: diagnostic issues for the coming decade.
• A novel syndrome of cerebral cavernous malformation and Greig cephalopolysyndactyly. Laboratory investigation.
• Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
• Recent advances in Tourette syndrome.
• Rare deleterious mutations of the gene EFR3A in autism spectrum disorders.
• Heterozygous 5p13.3-13.2 deletion in a patient with type I Chiari malformation and bilateral Duane retraction syndrome.
• Additional support for the association of SLITRK1 var321 and Tourette syndrome.
• Eating themselves to death: have "personal rights" gone too far in treating people with Prader-Willi syndrome?
• Mental retardation: a review of the past 10 years. Part I.
• Mental retardation: a review of the past 10 years. Part II.
• Effects of electroconvulsive therapy in adolescents with severe endogenous depression resistant to pharmacotherapy.
• Cerebrospinal fluid levels of oxytocin in Prader-Willi syndrome: a preliminary report.
• Obsessive-compulsive symptoms in Prader-Willi and "Prader-Willi-Like" patients.
• Cytokines and airways: recent insights and therapeutic implications.
• Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP).
• Pharmacologic management of psychiatric and behavioral symptoms in mental retardation.

Schools

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• Stanford University School Of Medicine

• California Pacific Med Center

• UCLA Neuropsychiatric Hospital

• Yale Psychiatric Institute

Doctors Specialties

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• Psychiatry

Accepted Insurances

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Awards

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• Member
• Ruane Prize for Research in Child and Adolescent Psychiatry

Education

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• Yale University School of Medicine
• UCLA Medical Center
• California Pacific Medical Center - Pacific Campus
• Stanford University School of Medicine

Hospital

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• Yale-New Haven Hospital
• UCSF Medical Center
• San Francisco General Hospital and Trauma Center

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