Professor, Pediatrics, Washington University School of Medicine
Pediatric Hematology & Oncology
Dr. Mary C. Dinauer, MD
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Mary Dinauer practices Pediatric Hematology & Oncology. He went to University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine He received 1 awards: "Elected Member". Mary Dinauer is also a published doctor. He has 97 paper published. The most recent paper is: Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
Publications
- Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic.
- Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.
- An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD.
- Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
- Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.
- The Dual Effect of Rac2 on Phospholipase D2 Regulation That Explains both the Onset and Termination of Chemotaxis.
- Evidence for Two CRIB Domains in Phospholipase D2 (PLD2) That the Enzyme Uses to Specifically Bind to the Small GTPase Rac2.
- Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.
- Gene therapy of chronic granulomatous disease: the engraftment dilemma.
- Interferon-{gamma} Production by Neutrophils during Bacterial Pneumonia in Mice.
- Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice.
- p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.
- Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner.
- Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.
- Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.
- A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
- Activation of antibacterial autophagy by NADPH oxidases.
- Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth.
- A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.
- Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.
- Mutational analysis reveals distinct features of the Nox4-p22 phox complex.
- Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.
- The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts.
- Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury.
- Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.
- Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
- A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activ...
- Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.
- Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.
- Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor m...
- The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
- Disorders of neutrophil function: an overview.
- Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity.
- The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and sup...
- The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.
- The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells.
- Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenou...
- p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.
- Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease.
- p40phox: the last NADPH oxidase subunit.
- Newly diagnosed chronic granulomatous disease in a 53-year-old woman with Crohn disease.
- Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways.
- Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.
- Chronic granulomatous disease and other disorders of phagocyte function.
- Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit.
- Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells.
- Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles.
- Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease.
- Rac2 is critical for neutrophil primary granule exocytosis.
- Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.
- The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions.
- Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Del...
- Regulation of neutrophil function by Rac GTPases.
- Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model.
- Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil...
- Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function.
- Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans.
- Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components.
- Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.
- Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system.
- Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- m...
- Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease.
- Inherited Neutrophil Disorders: Molecular Basis and New Therapies.
- Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.
- Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.
- Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
- Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource.
- Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation.
- SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells.
- Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3.
- Rac2 concentrations in umbilical cord neutrophils.
- A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications.
- Unusual polyclonal anti-gp91 peptide antibody interactions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression o...
- Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox.
- [Expression and activity of polymorphisms in the 67-kDa protein of the NADPH oxidase system].
- In vivo role of myeloperoxidase for the host defense.
- Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in th...
- Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985.
- Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus.
- Safety of retroviral gene marking with a truncated NGF receptor.
- Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.
- Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer...
- Splice site mutations are a common cause of X-linked chronic granulomatous disease.
- Chronic granulomatous disease presenting in a 69-year-old man.
- Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous dis...
- Interferon-gamma and chronic granulomatous disease.
- Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell.
- Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomat...
- Library subtraction of in vitro cDNA libraries to identify differentially expressed genes in scrapie infection.
- Association of a Ras-related protein with cytochrome b of human neutrophils.
- A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.
- Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous disease.
- Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma.
- Molecular genetics of chronic granulomatous disease.
- Chronic granulomatous disease. Molecular genetics.
- Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Children39s Hospital Boston
Doctors Specialties
- Pediatrics
- Pediatric Hematology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Group Employees PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Coventry Health Care of Missouri PPO
- HealthLink PPO
- Homestate Health Plan
- Choice Care PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
Education
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UCSF -
University of Chicago Pritzker School of Medicine
Hospital
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St. Louis Children's Hospital
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