Physician
Pathology
Dr. Mark S. Redston, MD
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Mark Redston is an expert in the field of Pathology. Mark Redston has written publications. He has 99 publications published with PubMed. The lastest publication is: 'Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.'
Publications
- Importance of universal mismatch repair protein immunohistochemistry in patients with sebaceous neoplasia as an initial screening tool for Muir-Torre syndrome.
- Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome.
- O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.
- A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
- Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
- Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
- High-resolution characterization of the pancreatic adenocarcinoma genome.
- Successful treatment of cap polyposis with infliximab.
- Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
- p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.
- Allelotype of pancreatic adenocarcinoma using xenograft enrichment.
- p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma.
- Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
- Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
- Klenow co-sequencing: a method for eliminating "stops".
- Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
- The hepatic von Meyenburg complex: prevalence and association with hepatic and renal cysts among 2843 autopsies [corrected].
- Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations.
- Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity.
- Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
- P53 protein accumulation in non-invasive lesions surrounding p53 mutation positive invasive breast cancers.
- Carcinogenesis in the GI tract: from morphology to genetics and back again.
- Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis.
- p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast.
- Risk of dysplasia in long-term ileal pouches and pouches with chronic pouchitis.
- Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyc...
- Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
- A preventive registry for hereditary nonpolyposis colorectal cancer.
- Using genetic information to make surgical decisions: report of a case of a 13-year-old boy with colon cancer.
- Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.
- Adenomyoma of the common bile duct imaged with endoscopic ultrasonography: case report.
- The diagnostic challenge of vasculitis in a patient presenting with acute cholecystitis and a focal pancreatic mass: case report.
- Molecular biology of colorectal cancer.
- p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias.
- Analysis of mRNA from microdissected frozen tissue sections without RNA isolation.
- p53 alterations in oesophageal cancer: association with clinicopathological features, risk factors, and survival.
- The APCI1307K allele and breast cancer risk.
- Somatic instability of the APC I1307K allele in colorectal neoplasia.
- Distinct regions of frequent loss of heterozygosity of chromosome 5p and 5q in human esophageal cancer.
- Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
- Family history characteristics, tumor microsatellite instability and germline MSH2 and MLH1 mutations in hereditary colorectal cancer.
- Mismatch repair gene defects contribute to the genetic basis of double primary cancers of the colorectum and endometrium.
- Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.
- STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.
- Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors.
- A missense mutation in both hMSH2 and APC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening.
- Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer.
- Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations.
- Molecular genetic profiles of colitis-associated neoplasms.
- Allelotype of pancreatic adenocarcinoma.
- MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.
- The effect of inhibitors of endogenous opioid degradation, bacitracin, bestatin, captopril, and D-phenylalanine, on digoxin-induced arrhythmias in guinea pigs.
- MSH2 deficient mice are viable and susceptible to lymphoid tumours.
- Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001.
- Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer.
- Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.
- alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.
- Sentinel node staging of resectable colon cancer: results of a multicenter study.
- Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.
- Microsatellite instability as a prognostic factor in resected colorectal cancer liver metastases.
- Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer.
- Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth ...
- Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin.
- Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin.
- Carnosol inhibits beta-catenin tyrosine phosphorylation and prevents adenoma formation in the C57BL/6J/Min/+ (Min/+) mouse.
- Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon.
- CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions.
- Tumor microsatellite instability in early onset gastric cancer.
- Cytokeratin 20 expression identifies a subtype of pancreatic adenocarcinoma with decreased overall survival.
- Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.
- Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
- Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.
- Mutation profiling of mismatch repair-deficient colorectal cncers using an in silico genome scan to identify coding microsatellites.
- Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor.
- Multi-detector row helical CT in preoperative assessment of small (< or = 1.5 cm) liver metastases: is thinner collimation better?
- Heterozygosity for the BLM(Ash) mutation and cancer risk.
- Assembling a tumor progression model.
- Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
- Hereditary nonpolyposis colorectal cancer--molecular basis.
- Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer.
- Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
- Aberrant crypt foci in the adenoma prevention with celecoxib trial.
- Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia ...
- p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
- Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial.
- Microsatellite Instability and Loss of Heterozygosity at Chromosomal Location 18q: Prospective Evaluation of Biomarkers for Stages II and III Colon Cancer--A Study of ...
- Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia.
- Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.
- DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor.
- Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor.
- Celecoxib for the prevention of sporadic colorectal adenomas.
- Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice.
- Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study.
- Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases.
- Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
- Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia.
- Hyperplastic/serrated polyposis in inflammatory bowel disease: a case series of a previously undescribed entity.
- High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma.
Schools
University of British Columbia Faculty of Medicine
University Western Ont
University Toronto
Johns Hopkins Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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University of British Columbia Faculty of Medicine
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