Executive Vice Chancellor MassBiologics of UMMS
Infectious Disease
Dr. Mark S. Klempner, MD
|
|
Give Review
Mark Klempner is an expert in the field of Infectious Disease. He researched medicine at Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18/49 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Dr. Mark S. Klempner is a published MD. He published 100 publications, including: 'Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera.'
Publications
- Immune response to endothelial cell growth factor is associated with early disseminated and late manifestations of Lyme disease but not with post-treatment Lyme diseas...
- Treatment trials for post-lyme disease symptoms revisited.
- Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance.
- Case records of the Massachusetts General Hospital. Case 25-2010. A 24-year-old woman with abdominal pain and shock.
- Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms.
- Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
- Taking a bite out of vector-transmitted infectious diseases.
- CD14 mediates cross talk between mononuclear cells and fibroblasts for upregulation of matrix metalloproteinase 9 by Borrelia burgdorferi.
- The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Dis...
- A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease.
- Disaster, water, cholera, vaccines, and hope.
- Crossing the species barrier--one small step to man, one giant leap to mankind.
- Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon.
- Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute lyme disease.
- Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease.
- A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor.
- Navigating life review interviews with survivors of trauma.
- An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.
- Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in pa...
- The beta-adrenergic receptor in the human neutrophil plasma membrane: receptor-cyclase uncoupling is associated with amplified GTP activation.
- Alkalinization of the intralysosomal pH by clindamycin and its effects on neutrophil function.
- Effects of leukocyte inhibitory factor (LIF) on human neutrophil function.
- Internal pH of human neutrophil lysosomes.
- Identification of a human neutrophil angiotension II-generating protease as cathepsin G.
- Clindamycin uptake by human neutrophils.
- Leukocyte uptake of daunomycin.
- Differential lysis of plasma membranes and granules of human neutrophils by digitonin.
- In vitro evaluation of clindamycin in combination with oxacillin, rifampin, or vancomycin against Staphylococcus aureus.
- Inhibition of macrophage secretion by tetanus toxin is not directly linked to cytosolic calcium homeostasis.
- Tetanus toxin inhibits secretion of lysosomal contents from human macrophages.
- Probing the phagolysosomal environment of human macrophages with a Ca2+-responsive operon fusion in Yersinia pestis.
- Linkage between neutrophil degranulation and calcium discharge.
- Calcium release associated with discharge of specific granule contents from human neutrophils.
- Lysosomotropic amines modulate neutrophil calcium homeostasis.
- Diminished activity of protein kinase C in tetanus toxin-treated macrophages and in the spinal cord of mice manifesting generalized tetanus intoxication.
- Effects of pH on killing of Staphylococcus aureus and Escherichia coli by constituents of the neutrophil phagolysosome.
- Prevention of recurrent staphylococcal skin infections with low-dose oral clindamycin therapy.
- Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils.
- Leukocyte inhibitory factor (LIF) potentiates neutrophil responses to formyl-methionyl-leucyl-phenylalanine.
- Inhibition of neutrophil oxidative metabolism by lysosomotropic weak bases.
- Modification of interactions between neutrophils and staphylococci by lysosomotropic weak bases.
- Inhibition of neutrophil superoxide production by fanetizole.
- Lysosomotropic behavior of adrenergic antagonists in interactions with human neutrophils.
- In vitro effects of omega-3 fatty acids on neutrophil intracellular calcium homeostasis and receptor expression for FMLP and LTB4.
- Comparison of prostaglandins E2 and D2 as inhibitors of respiratory burst in neutrophils from atopic and nonatopic subjects.
- Characterization of the neutrophil respiratory burst in atopy.
- The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.
- An abnormal calcium uptake pump in Chediak-Higashi neutrophil lysosomes.
- Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.
- Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression...
- Yersinia pestis pH 6 antigen: genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague.
- An acquired chemotactic defect in neutrophils from patients receiving interleukin-2 immunotherapy.
- Neutrophil chemotactic factors in synovial fluids of patients with Lyme disease.
- Infectivity of Borrelia burgdorferi correlates with resistance to elimination by phagocytic cells.
- Chronic granulomatous disease presenting in a 69-year-old man.
- Fibroblasts protect the Lyme disease spirochete, Borrelia burgdorferi, from ceftriaxone in vitro.
- Comparison of granulocyte-macrophage colony stimulating factor and interleukin-1 production from human peripheral blood mononuclear cells as measured by specific radio...
- Central nervous system disease in systemic lupus erythematosus. Therapy and prognosis.
- Inhibition of neutrophil Fc receptor function by cotricosteroids.
- Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.
- Separation and functional characterization of human neutrophil subpopulations.
- Endocarditis due to resistant viridans streptococci during oral penicillin chemoprophylaxis.
- Stimulation of neutrophil oxygen-dependent metabolism by human leukocytic pyrogen.
- Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown origin.
- Binding of human urokinase type plasminogen activator and plasminogen to Borrelia species.
- Inhibition of Borrelia burgdorferi-bound fibrinolytic enzymes by alpha2-antiplasmin, PAI-1 and PAI-2.
- Invasion of human skin fibroblasts by the Lyme disease spirochete, Borrelia burgdorferi.
- Mycobacterium bovis infection of an implantable defibrillator following intravesical therapy with bacille Calmette-Guérin.
- Binding of human plasminogen and urokinase-type plasminogen activator to the Lyme disease spirochete, Borrelia burgdorferi.
- Binding of human plasminogen to Borrelia burgdorferi.
- Training in infectious disease: planning for the future.
- Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation.
- The effect of hemodialysis and C5a des arg on neutrophil subpopulations.
- Phospholipase A2 activity in the plasma membrane of human polymorphonuclear leukocytes.
- Alterations in opsonophagocytic killing by neutrophils of Bacteroides fragilis associated with animal and laboratory passage: effect of capsular polysaccharide.
- Specific binding of leukocyte inhibitory factor to neutrophil plasma membranes.
- Disorders of phagocyte chemotaxis.
- Attachment of plasma membrane vesicles of human macrophages to Leishmania tropica promastigotes.
- Late-presenting variant of chronic granulomatous disease.
- Alkalinizing the intralysosomal pH inhibits degranulation of human neutrophils.
- Interactions of polymorphonuclear leukocytes with anaerobic bacteria.
- Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease.
- Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment.
- Functional testing of putative oligopeptide permease (Opp) proteins of Borrelia burgdorferi: a complementation model in opp(-) Escherichia coli.
- Update on the prevention, diagnosis, and treatment of Lyme disease.
- Intralaboratory reliability of serologic and urine testing for Lyme disease.
- Soluble CD14 levels in the serum, synovial fluid, and cerebrospinal fluid of patients with various stages of Lyme disease.
- Borrelia burgdorferi induces matrix metalloproteinases by neural cultures.
- Is it thee or me?--autoimmunity in Lyme disease.
- Beyond us versus them.
- Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera.
- Recombinant human interleukin-11 does not affect functions of purified human neutrophils in vitro.
- A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Stud...
- Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors.
- Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous menin...
- Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis.
- Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi.
- Host-pathogen interactions in the immunopathogenesis of Lyme disease.
- Detection of a 130-kD matrix metalloproteinase in cerebrospinal fluid from a patient with Lyme neuroborreliosis.
Schools
Weill Cornell Medical College
Massachusetts General Hospital
Nih Niaid
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
-
Massachusetts General Hospital -
Weill Cornell Medical College of Cornell University
Hospital
-
UMass Memorial Medical Center -
Boston Medical Center
Helpful Reviews
Similar Doctors
|
|
Dr. Jennifer P. Wang, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Thomas C. Greenough, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Sheryn M. Angelis, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Lisa M. Bocelli, DO
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Stuart M. Levitz, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Laura L. Gibson, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Anthony L. Esposito, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Steven C. Hatch, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Francis A. Ennis, MD
This Doctor is OpenDoctor Recommended.
|