Professor, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine
Rheumatology
Dr. Mark R. Boothby, MD
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Mark Boothby works in the field of Rheumatology. He went to medical school at Washington University School of Medicine in St. Louis. Mark Boothby is also a published MD. He has 91 paper published. The most recent paper is: Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.
Publications
- Regulation of Endothelial Cell Proliferation and Vascular Assembly through Distinct mTORC2 Signaling Pathways.
- Myeloid IKKβ Promotes Antitumor Immunity by Modulating CCL11 and the Innate Immune Response.
- B Cell-Intrinsic and -Extrinsic Regulation of Antibody Responses by PARP14, an Intracellular (ADP-Ribosyl)Transferase.
- Requirement for Rictor in homeostasis and function of mature B lymphoid cells.
- STAT4 and T-bet Are Required for the Plasticity of IFN-γ Expression across Th2 Ontogeny and Influence Changes in Ifng Promoter DNA Methylation.
- Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction.
- The goldilocks effect.
- IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells.
- An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.
- NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.
- Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.
- Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells.
- Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.
- NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes.
- Interleukin-4 and interleukin-13 signaling connections maps.
- Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity.
- Alterations in lung collectins in an adaptive allergic immune response.
- Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis.
- Control of immunoglobulin heavy chain constant region gene expression.
- Imbalanced synthesis of human choriogonadotropin alpha and beta subunits reflects the steady state levels of the corresponding mRNAs.
- A single gonadotropin alpha-subunit gene in normal tissue and tumor-derived cell lines.
- Segregation patterns of polymorphic restriction sites of the gene encoding the alpha subunit of human chorionic gonadotropin in trophoblastic disease.
- The beta subunit of human chorionic gonadotropin is encoded by multiple genes.
- The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis.
- Distinct IL-4 response mechanisms of the MHC gene A alpha in different mouse B cell lines.
- Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin.
- Specificity of sn50 for NF-kappa B?
- Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element.
- Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene A alpha.
- The presence of a DNA binding complex correlates with E beta class II MHC gene expression.
- Control of transcription at the murine A alpha locus.
- Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene.
- Differences in DNA sequence specificity among MHC class II X box binding proteins.
- IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes.
- The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter.
- Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.
- A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B.
- Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element.
- Rapid commitment to negative selection of a thymocyte line independent of CD4 co-engagement.
- A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
- HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor.
- Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells.
- Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL.
- Lymphokine-dependent proliferation of T-lymphoid cells: regulated responsiveness and role in vivo.
- IL-4 signaling, gene transcription regulation, and the control of effector T cells.
- IL-4-dependent induction of BCL-2 and BCL-X(L)IN activated T lymphocytes through a STAT6- and pi 3-kinase-independent pathway.
- NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis.
- Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways.
- A DNA binding protein regulated by IL-4 and by differentiation in B cells.
- Redirection of T cell effector function in vivo and enhanced collagen-induced Arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene.
- NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells.
- Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.
- Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.
- Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation.
- Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling.
- Essential role of T cell NF-kappa B activation in collagen-induced Arthritis.
- Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation.
- Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.
- In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.
- Inhibition of NF-kappaB-dependent T cell activation abrogates acute allograft rejection.
- Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel.
- A minimal IFN-gamma promoter confers Th1 selective expression.
- CTLA-4 engagement regulates NF-kappaB activation in vivo.
- TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism.
- Constitutive expression of BCL-X(L) in the T lineage attenuates collagen-induced Arthritis in Bcl-X(L) transgenic mice.
- Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii.
- Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor.
- Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
- New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines.
- T cell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response.
- T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site.
- Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells.
- Signaling advances from immunogenetics to immunogenomics.
- Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells.
- Differential roles of C-terminal activation motifs in the establishment of Stat6 transcriptional specificity.
- An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.
- The calculus of integrating differentiation: timing control of T-bet.
- PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.
- Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.
- Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription.
- T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
- Oxidant stress modulates murine allergic airway responses.
- Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor.
- Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes.
- Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family.
- A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS.
- Progress in the function and regulation of ADP-Ribosylation.
- Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.
- CRACking the code without Rosetta: molecular regulation of calcium-stimulated gene transcription after T cell activation.
- Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
Schools
Washington Center School of Medicine
Conditions Treated
- Arthritis
- Rheumatoid Arthritis
Doctors Specialties
- Rheumatology
Accepted Insurances
Education
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Brigham and Women's Hospital -
University of Colorado -
Washington University School of Medicine in St. Louis
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