Physician
Cardiology
Dr. Mark O'Connor, MD
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Mark O'Connor, MD works in the field of Cardiology. He attended University of Michigan Medical School. He received 2 awards: "Meaningful Use Stage 1 Certification" and "Fellow (FACC)". Mark O'Connor is a published doctor. He published 28 publications, including: 'DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- phenanthroline terephthalate.'
Publications
- Glucan particles for selective delivery of siRNA to phagocytic cells in mice.
- Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
- Activated germinal centre B cells undergo directed migration.
- Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.
- Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts.
- Gene transfer in Drosophila.
- Suppression of retroviral infection by the RAD52 DNA repair protein.
- The overexpression of specialized DNA polymerases in cancer.
- Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase.
- A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.
- hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.
- Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
- Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.
- 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.
- High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
- Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
- Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.
- ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
- Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.
- Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carbopla...
- Measuring improvement in depression in cancer patients: a 50% drop on the self-rated SCL-20 compared with a diagnostic interview.
- Screening for major depression in cancer outpatients: the diagnostic accuracy of the 9-item patient health questionnaire.
- Proteomics success story. Novel biomarkers for DNA damage response pathways: insights and applications for cancer therapy.
- Screening for suicidality in cancer patients using Item 9 of the nine-item patient health questionnaire; does the item score predict who requires further assessment?
- Monitoring symptoms at home: what methods would cancer patients be comfortable using?
- DNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- phenanthroline terephthalate.
- Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with ''self-activating'' metallo-nuclease and DNA binding properties.
Schools
University Of Michigan Medical School
Loyola University Med Center
University Of Mi Hosps and Health Ctrs
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Automatic Implantable Cardioverter Defibrillator (ICD) Implantation
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
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Conditions Treated
- Aneurysm and Dissection of Heart
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Ectasia
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Doctors Specialties
- Cardiology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- American Republic
- Pathway X Tiered Hosp/Ind Direct Access OH
- Anthem Blue Cross Blue Shield HMO
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Blue Care Network PCP Focus Network
- Group Employees PPO
- CareSource
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Cofinity PPO
- Commercial Insurance Company
- Coventry Health America PPO
- First Health (Coventry Health Care) PPO
- Frontpath Health Coalition
- Health Alliance
- Preferred PPO
- Choice Care PPO
- Medicaid
- Medical Mutual of Ohio POS
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Mutual of Omaha
- NGS CoreSource
- Paramount
- Priority PPO
- Thrivent Financial
- Tricare
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Meaningful Use Stage 1 Certification
- Fellow (FACC)
Education
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University of Michigan Hospitals and Health Centers -
University of Washington -
University of Michigan Medical School
Hospital
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Mercy St. Vincent Medical Center -
ProMedica Toledo Hospital
Drug Facts
| NPI NUMBER | 1245232800 | |
| NPPES Provider LastName | O'CONNOR | |
| NPPES Provider FirstName | MARK | |
| NPPES Provider ZIPCode | 436082625 | |
| NPPES Provider State | OH | |
| Specialty Description | Cardiology | |
| Total Claim Count | 6201.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1245232800 |
| Last Name Of The Provider | O'CONNOR |
| First Name Of The Provider | MARK |
| View All |
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