Professor, Laboratory Medicine, Yale University School of Medicine
Pathology
Dr. Mark J. Shlomchik, MD
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Mark Shlomchik practices Pathology. He attended Perelman School of Medicine at the University of Pennsylvania. He has 1 awards "Elected Member". Dr. Mark J. Shlomchik has written publications. He has 101 publications published with PubMed. The lastest paper is: 'B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.'
Publications
- B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.
- Local Triggering of the ICOS Coreceptor by CD11c(+) Myeloid Cells Drives Organ Inflammation in Lupus.
- Antibody Effector Functions Mediated by Fcγ-Receptors Are Compromised during Persistent Viral Infection.
- Suppression of systemic autoimmunity by the innate immune adaptor STING.
- CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype.
- Activation of Rheumatoid Factor-Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model.
- Targeting Antigens through Blood Dendritic Cell Antigen 2 on Plasmacytoid Dendritic Cells Promotes Immunologic Tolerance.
- IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.
- Integrating B Cell Lineage Information into Statistical Tests for Detecting Selection in Ig Sequences.
- Spontaneous loss of tolerance of autoreactive B cells in act1-deficient rheumatoid factor transgenic mice.
- Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes.
- Exacerbated Autoimmunity in the Absence of TLR9 in MRL.Faslpr Mice Depends on Ifnar1.
- Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus.
- Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses.
- TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation.
- Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.
- NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.
- B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity.
- B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.
- Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.
- An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus.
- A repertoire-independent and cell intrinsic defect in murine GVHD induction by effector memory T cells.
- Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⺠effector memory T cells.
- Detecting selection in immunoglobulin sequences.
- Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.
- Langerhans cells are not required for graft-versus-host disease.
- Cutting edge: Hierarchy of maturity of murine memory B cell subsets.
- Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage.
- Plasticity and heterogeneity in the generation of memory B cells and long-lived plasma cells: the influence of germinal center interactions and dynamics.
- Recipient B cells are not required for graft-versus-host disease induction.
- PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.
- Single round of antigen receptor signaling programs naive B cells to receive T cell help.
- TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus.
- Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in...
- Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells.
- Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides.
- Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.
- Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.
- Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.
- Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice.
- Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge.
- Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of ...
- Requirement of B cells for generating CD4+ T cell memory.
- Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation.
- Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha.
- BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact.
- T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells.
- Langerhans cells are not required for efficient skin graft rejection.
- Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities.
- Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells.
- Maintenance of the plasma cell pool is independent of memory B cells.
- Sites and stages of autoreactive B cell activation and regulation.
- Memory T cells in GVHD and GVL.
- Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice.
- Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.
- New markers for murine memory B cells that define mutated and unmutated subsets.
- Depletion of B cells in murine lupus: efficacy and resistance.
- Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.
- Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation.
- B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation.
- Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.
- B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells.
- Recipient gammadelta T cells in graft-versus-host disease.
- Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells.
- B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation.
- Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
- RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
- Attenuated liver fibrosis in the absence of B cells.
- Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
- Histone modifications associated with somatic hypermutation.
- Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside...
- Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity.
- Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis.
- Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on tar...
- The role of innate immunity in autoimmunity.
- Target antigens determine graft-versus-host disease phenotype.
- Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.
- Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease.
- Activation of autoreactive B cells by CpG dsDNA.
- Estimating hypermutation rates from clonal tree data.
- The B cell receptor itself can activate complement to provide the complement receptor 1/2 ligand required to enhance B cell immune responses in vivo.
- Memory CD4+ T cells do not induce graft-versus-host disease.
- Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice.
- Evolution of autoantibody responses via somatic hypermutation outside of germinal centers.
- Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced.
- Mechanisms of central nervous system viral persistence: the critical role of antibody and B cells.
- CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence.
- A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation.
- Activating systemic autoimmunity: B''s, T''s, and tolls.
- Improved methods for detecting selection by mutation analysis of Ig V region sequences.
- Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites.
- Antigen presentation and transfer between B cells and macrophages.
- In vivo imaging studies shed light on germinal-centre development.
- Reassessing the function of immune-complex retention by follicular dendritic cells.
- Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors.
- Autoimmunity: The genes and phenotypes of autoimmunity.
- The role of antibodies and B cells in the pathogenesis of lupus nephritis.
- Rheumatoid factors in health and disease: structure, function, induction and regulation.
- Intrinsic properties of human and murine memory B cells.
- Antibody-independent B cell-intrinsic and -extrinsic roles for CD21/35.
Schools
Perelman School of Medicine University of Pennsylvania
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
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University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
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