Professor of Surgery, UCSF

General Surgery

Mark B. Ratcliffe practices General Surgery. He graduated from Case Western Reserve University School of Medicine. He has 1 awards "Fellow (FACS)". Mark Ratcliffe has written publications. He has 88 publications published with PubMed. The lastest paper is: 'The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: a simple finite element analysis.'

Publications

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• Studies on postinfarct left ventricular remodeling: state of the art.
• Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.
• Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.
• Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function.
• Applications of Computational Modeling in Cardiac Surgery.
• Measurement of Mitral Leaflet and Annular Geometry and Stress After Repair of Posterior Leaflet Prolapse: Virtual Repair Using a Patient-Specific Finite Element Simula...
• Analysis of patient-specific surgical ventricular restoration: importance of an ellipsoidal left ventricular geometry for diastolic and systolic function.
• Biventricular Finite Element Modeling of the Acorn CorCap Cardiac Support Device on a Failing Heart.
• Left Ventricular Myocardial Contractility Is Depressed in the Borderzone After Posterolateral Myocardial Infarction.
• Material Properties of CorCap Passive Cardiac Support Device.
• Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration.
• The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.
• A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
• The Effect of Mitral Annuloplasty Shape in Ischemic Mitral Regurgitation: A Finite Element Simulation.
• Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle - a finite element model study.
• Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
• A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
• Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
• Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.
• Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future.
• A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns.
• A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular Aneurysm.
• A simple correction for anomalous coronary arteries in adults.
• National Institutes of Health funding for cardiothoracic surgical research.
• Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular Aneurysm.
• National institutes of health funding for surgical research.
• Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging.
• Endoventricular patch plasty for dyskinetic anteroapical left ventricular Aneurysm increases systolic circumferential shortening in sheep.
• The effect of preoperative diastolic dysfunction on outcome after surgical ventricular remodeling.
• Theoretical impact of the injection of material into the myocardium: a finite element model simulation.
• The treatment of ischemic heart failure with surgical ventricular restoration (SVR): new evidence of benefit.
• The effect of anteroapical Aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.
• Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular Aneurysm in sheep.
• MRI-based finite-element analysis of left ventricular Aneurysm.
• Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study.
• Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep.
• Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study.
• Effect of preoperative delay on prognosis for patients with early stage non-small cell lung cancer.
• A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy.
• Ventricular remodeling surgery for heart failure: small animals and how to measure an improvement in ventricular function.
• Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure.
• Cardiopulmonary Complications Following Cardiac Surgery.
• A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium.
• A comparison of epanolol and nifedipine in stable angina patients: results of a multicentre trial.
• Use of concomitant medication with antipsychotic treatment in outpatients with schizophrenia: results from the European Schizophrenia Outpatients Health Outcomes (SOHO...
• Thrombosis, markers of thrombotic risk, indwelling central venous catheters and antithrombotic prophylaxis using low-dose warfarin in subjects with malignant disease.
• Remission and relapse in the outpatient care of schizophrenia: three-year results from the Schizophrenia Outpatient Health Outcomes study.
• Batista's operation: what have we learned?
• Cost-utility analysis of treatment with olanzapine compared with other antipsychotic treatments in patients with schizophrenia in the pan-European SOHO study.
• A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.
• Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thromboc...
• The use of computational flow modeling (CFD) to determine the effect of left ventricular shape on blood flow in the left ventricle.
• Severe Aortic stenosis in a veteran population: treatment considerations and survival.
• Mechanism underlying mechanical dysfunction in the border zone of left ventricular Aneurysm: a finite element model study.
• Ventricular volume, chamber stiffness, and function after anteroapical Aneurysm plication in the sheep.
• L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery.
• The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: a simple finite element analysis.
• Dynamic three-dimensional imaging of the mitral valve and left ventricle by rapid sonomicrometry array localization.
• Large animal model of ischemic mitral regurgitation.
• Changes in passive mechanical stiffness of myocardial tissue with Aneurysm formation.
• Left ventricular assist without thoracotomy: clinical experience with the Dennis method.
• Use of sonomicrometry and multidimensional scaling to determine the three-dimensional coordinates of multiple cardiac locations: feasibility and initial implementation.
• Pathogenesis of acute ischemic mitral regurgitation in three dimensions.
• Flow dynamics of peripheral venous catheters during extracorporeal membrane oxygenation with a centrifugal pump.
• Open-heart surgery in octogenarians.
• Changes in left ventricular systolic wall stress during biventricular circulatory assistance.
• Measurement of end-systolic pressure-volume relations by intra-Aortic balloon occlusion.
• Surgery for left ventricular Aneurysm. Early survival with and without endocardial resection.
• Large animal model of left ventricular Aneurysm.
• Myocardial oxygen utilization after reversible global ischemia.
• Left ventricular mechanics of ejecting, postischemic hearts during left ventricular circulatory assistance.
• Effect of induction and reperfusion with warm substrate-enriched cardioplegia on ventricular function.
• Collection of process data after cardiac surgery: initial implementation with a Java-based intranet applet.
• Radio frequency heating of chronic ovine infarct leads to sustained infarct area and ventricular volume reduction.
• The effect of diastolic stiffness on ventricular function after partial ventriculectomy: a finite element simulation.
• Repair of left ventricular Aneurysm. Changes in ventricular mechanics, hemodynamics, and oxygen consumption.
• Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study.
• Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.
• Asymmetric mechanical properties of porcine Aortic sinuses.
• Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations.
• The biomechanics of arterial elastin.
• Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study.
• First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
• Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
• A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.
• Operative risks and survival in veterans with severe Aortic stenosis: surgery versus medical therapy.
• Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infar...

Schools

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• Case Western Reserve University School of Medicine

• Hospital Of The University Of Pennsylvania

• Johns Hopkins

Conditions Treated

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• Aortic Aneurysm

Doctors Specialties

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• Cardiac Surgery
• General Surgery

Accepted Insurances

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Awards

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• Fellow (FACS)

Education

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• University of Pennsylvania Health System
• Johns Hopkins University
• Case Western Reserve University School of Medicine

Hospital

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• San Francisco General Hospital and Trauma Center
• San Francisco VA Medical Center
• UCSF Medical Center

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