Professor, Internal Medicine, UC, Davis School of Medicine
Gastroenterology
Dr. Mark A. Zern, MD
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Mark A. Zern works in the field of Gastroenterology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 1 awards "CMS Meaningful Use Stage 1 Certification". Mark Zern is a published doctor. He has 101 publications published. The most current publication "TNF-alpha modulates expression of the tissue transglutaminase gene in liver cells." He is registered with Medicare and accepts Medicare payments.
Publications
- CD34+ Liver Cancer Stem Cells were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates.
- Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells.
- Identification of cancer stem cell subpopulations of CD34+ PLC/PRF/5 that result in three types of human liver carcinomas.
- Insulin and IGFs Enhance Hepatocyte Differentiation from Human Embryonic Stem Cells via the PI3K/AKT Pathway.
- Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces.
- Human ESC Self-renewal Promoting microRNAs Induce Epithelial-Mesenchymal Transition in Hepatocytes by Controlling the PTEN and TGFβ Tumor Suppressor Signaling Pathways.
- Bottom-up signaling from HGF-containing surfaces promotes hepatic differentiation of mesenchymal stem cells.
- Decellularized liver matrix as a carrier for the transplantation of human fetal and primary hepatocytes in mice.
- New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes.
- Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations.
- Label-free imaging and analysis of the effects of lipolysis products on primary hepatocytes.
- Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma.
- Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells.
- Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation.
- Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1.
- Cell transplantation to replace whole liver transplantation.
- A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells.
- The differentiation of hepatocyte-like cells from monkey embryonic stem cells.
- Multifunctional protein microarrays for cultivation of cells and immunodetection of secreted cellular products.
- Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice.
- Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo.
- Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells.
- Short hairpin RNA causes the methylation of transforming growth factor-beta receptor II promoter and silencing of the target gene in rat hepatic stellate cells.
- Analysis of local tissue-specific gene expression in cellular micropatterns.
- Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice.
- Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo.
- Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency.
- Gene therapy for human alpha1-antitrypsin deficiency in an animal model using SV40-derived vectors.
- Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice.
- Tissue transglutaminase, a key enzyme involved in liver diseases.
- Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage.
- Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.
- Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential.
- In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging.
- Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors.
- Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications.
- Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation.
- Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases.
- Using growth factor arrays and micropatterned co-cultures to induce hepatic differentiation of embryonic stem cells.
- Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury.
- Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.
- Directing hepatic differentiation of embryonic stem cells with protein microarray-based co-cultures.
- Lentivirus-mediated superoxide dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice.
- Cultivating liver cells on printed arrays of hepatocyte growth factor.
- Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms.
- An optimal culture condition maintains human hepatocyte phenotype after long-term culture.
- De novo nonalcoholic fatty liver disease after liver transplantation.
- Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver.
- HIV-1 proprotein processing as a target for gene therapy.
- What can SV40-derived vectors do for gene therapy?
- SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity.
- The prospects of hepatic drug delivery and gene therapy.
- Toxicity of hepatotoxins: new insights into mechanisms and therapy.
- Increased transforming growth factor-beta 1 gene expression in human liver disease.
- The effects of hepatic fibrosis on Ito cell gene expression.
- Cytokines, hepatic fibrosis and schistosomiasis.
- Albumin and procollagen type I gene regulation in alcohol and viral-induced human liver disease.
- Two rat models of hepatic fibrosis. A morphologic and molecular comparison.
- Albumin and collagen gene regulation in alcohol- and virus-induced human liver disease.
- Ito-cell gene expression and collagen regulation.
- Ascorbate-generated endogenous extracellular matrix affects cell protein synthesis in calf aortic smooth muscle cells.
- Transcriptional switch from albumin to alpha-fetoprotein and changes in transcription of other genes during carbon tetrachloride induced liver regeneration.
- Hepatocellular copper toxicity and its attenuation by zinc.
- In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.
- Gamma-interferon treatment inhibits collagen deposition in murine schistosomiasis.
- Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury.
- Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization.
- Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor alpha.
- Haplotype analysis of a type I collagen gene and its association with alcoholic cirrhosis in man.
- Transcriptional and posttranscriptional effects of dexamethasone on albumin and procollagen messenger RNAs in murine schistosomiasis.
- Differential effects of gamma-interferon on collagen and fibronectin gene expression.
- Collagen chain mRNAs in isolated heart cells from young and adult rats.
- Relationship between serum cortisol, liver function, and depression in detoxified alcoholics.
- The effects of dexamethasone on in vitro collagen gene expression.
- Development of molecular hybridization technology to evaluate albumin and procollagen mRNA content in baboons and man.
- Effects of dexamethasone on albumin and collagen gene expression in primary cultures of adult rat hepatocytes.
- Increased type I procollagen mRNA levels and in vitro protein synthesis in the baboon model of chronic alcoholic liver disease.
- Recombinant DNA and the liver: studies with albumin, alpha-fetoprotein, hepatitis B virus, and other DNA probes.
- Use of in situ hybridization to identify collagen and albumin mRNAs in isolated mouse hepatocytes.
- Changes in collagen and albumin mRNA in liver tissue of mice infected with Schistosoma mansoni as determined by in situ hybridization.
- Molecular mechanisms for changes in hepatic protein synthesis induced by schistosomiasis infection in mice.
- Effects of chronic renal failure on protein synthesis and albumin messenger ribonucleic acid in rat liver.
- Development and use of a rat albumin cDNA clone to evaluate the effect of chronic ethanol administration on hepatic protein synthesis.
- Hepatic fibrosis and gene expression changes induced by praziquantel treatment during immune modulation of Schistosoma japonicum infection.
- FK506 enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats.
- Vitamin E therapy of acute CCl4-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding.
- An ounce of prevention: the development of viral hepatitis vaccines.
- Molecular biological aspects of alcohol-induced liver disease.
- Expression of SPARC in normal and fibrotic livers.
- Effect of vitamin E on reoxygenation injury experienced by isolated rat hepatocytes.
- Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1.
- Inhibition of carbon tetrachloride-induced liver injury by liposomes containing vitamin E.
- Gene expression of transforming growth factor beta 1 and extracellular matrix proteins in murine Schistosoma mansoni infection.
- Role of the cyclic AMP response element in rat fibronectin gene expression.
- A role for cytokines as regulators of hepatic fibrogenesis.
- Modification of liposomes for liver targeting.
- The antioxidant function of the physiological content of vitamin C.
- Hepatic drug delivery and gene therapy.
- A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB.
- TNF-alpha modulates expression of the tissue transglutaminase gene in liver cells.
Schools
Harvard Medical School
Doctors Specialties
- Internal Medicine
- Gastroenterology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Tufts Medical Center -
Harvard Medical School
Hospital
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University of California, Davis Medical Center
Drug Facts
| NPI NUMBER | 1275510687 | |
| NPPES Provider LastName | ZERN | |
| NPPES Provider FirstName | MARK | |
| NPPES Provider ZIPCode | 95817 | |
| NPPES Provider State | CA | |
| Specialty Description | Gastroenterology | |
| Total Claim Count | 708.0 | |
| Distinct Opioid Count | 1.0 | |
| Opioid Claim Count | 18.0 | |
| Percent Opioid Claims | 2.54 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1275510687 |
| Last Name Of The Provider | ZERN |
| First Name Of The Provider | MARK |
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