Associate Professor, Pathology, University of Pittsburgh School of Medicine
Pathology
Dr. Marie C. Defrances, MD
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Marie Defrances works in the field of Pathology. She graduated from University of Pittsburgh School of Medicine. Marie Defrances is a published physician. She published 22 publications, including: 'Liver regeneration.' She is registered with Medicare and accepts Medicare payments.
Publications
- Genomic Instability Causes HGF Gene Activation in Colon Cancer Cells, Promoting Their Resistance to Necroptosis.
- A novel death defying domain in met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes.
- A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism.
- The Met protooncogene is a transcriptional target of NF kappaB: implications for cell survival.
- Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer.
- Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure.
- PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma.
- Lack of Fas antagonism by Met in human fatty liver disease.
- PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.
- A mechanism of cell survival: sequestration of Fas by the HGF receptor Met.
- Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis.
- The repressive function of AP2 transcription factor on the hepatocyte growth factor gene promoter.
- The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice.
- Liver regeneration.
- Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation.
- Expression of HGF-SF in normal and malignant human tissues.
- Expression and characterization of biologically active human hepatocyte growth factor (HGF) by insect cells infected with HGF-recombinant baculovirus.
- Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript.
- Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas.
- Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth fac...
- Unusual tumors involving the head and neck region: case 1. Angiosarcoma of the scalp.
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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University of Pittsburgh Medical Center -
University of Pittsburgh School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1851364004 |
| Last Name Of The Provider | DEFRANCES |
| First Name Of The Provider | MARIE |
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