Chief, Systemic Autoimmunity Branch, NIAMS/NIH
Rheumatology
Dr. Mariana J. Kaplan, MD
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Mariana Kaplan works in the field of Rheumatology. He received 4 awards: "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Fellow" and "Fellow (FACR)". Mariana Kaplan is a published doctor and has 63 publications published. The lastest was: 'Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.'
Publications
- At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune Diseases.
- Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.
- Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like Disease.
- Pathogenic immunity in systemic Lupus erythematosus and atherosclerosis: common mechanisms and possible targets for intervention.
- Epigenome profiling reveals significant DNA demethylation of interferon signature genes in Lupus neutrophils.
- Design, synthesis, and biological evaluation of tetrazole analogs of cl-amidine as protein arginine deiminase inhibitors.
- Interleukin 10 hampers endothelial Cell differentiation and enhances the effects of interferon α on lupus endothelial Cell progenitors.
- The inflammasome and lupus: another innate immune mechanism contributing to Disease pathogenesis?
- Neutrophil extraCellular trap-derived enzymes oxidize high-density lipoprotein: An additional proatherogenic mechanism in systemic lupus erythematosus.
- Reply to Drs. Pollard and Kono, scripps research institute.
- Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.
- Neutrophil extraCellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2.
- Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis.
- An essential role of caspase 1 in the induction of murine Lupus and its associated vascular damage.
- Prevalence of subclinical atherosclerosis is increased in systemic sclerosis and is associated with serum proteins: a cross-sectional, controlled study of carotid ultr...
- Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus.
- Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease.
- An essential role for caspase-1 in the induction of murine Lupus and its associated vascular damage.
- Cardiovascular Disease in lupus: insights and updates.
- The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor Cells: results from a randomized cont...
- Vitamin D Deficiency, Interleukin 17, and Vascular Function in Rheumatoid Arthritis.
- The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T Cell responses in systemic lupus erythematosus.
- Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity.
- Neutrophil ExtraCellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages.
- High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid Arthritis.
- Photoacoustic and ultrasound dual-modality imaging of human peripheral joints.
- Mechanisms of Premature Atherosclerosis in Rheumatoid Arthritis and Lupus.
- Neutrophil extraCellular traps: double-edged swords of innate immunity.
- Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of Lupus and atherosclerosis.
- Type I interferons are associated with subclinical markers of cardiovascular Disease in a cohort of systemic lupus erythematosus patients.
- Inflammasome activation of IL-18 results in endothelial progenitor Cell dysfunction in systemic lupus erythematosus.
- Neutrophils in the pathogenesis and manifestations of SLE.
- Interleukin 17 as a novel predictor of vascular function in rheumatoid Arthritis.
- Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus.
- Mast Cells and Neutrophils Release IL-17 through ExtraCellular Trap Formation in Psoriasis.
- Determinants of vascular function in patients with Chronic gout.
- The interplay of inflammation and cardiovascular Disease in systemic lupus erythematosus.
- How does interferon-α insult the vasculature? Let me count the ways.
- How does IFN-α insult the vasculature? let me count the ways.
- The detrimental effects of IFN-α on vasculogenesis in Lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascul...
- Cardiovascular complications of rheumatoid Arthritis: assessment, prevention, and treatment.
- A distinct subset of proinflammatory neutrophils isolated from patients with systemic Lupus erythematosus induces vascular damage and synthesizes type I IFNs.
- Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T Cells.
- The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine Lupus.
- Premature vascular damage in systemic Lupus erythematosus: an imbalance of damage and repair?
- Management of cardiovascular disease risk in Chronic inflammatory disorders.
- Interferon-alpha promotes abnormal vasculogenesis in Lupus: a potential pathway for premature atherosclerosis.
- Is rheumatoid Arthritis a risk factor for cardiovascular disease?
- Dendritic Cells and the immunopathogenesis of systemic lupus erythematosus.
- Aberrant phenotype and function of myeloid dendritic Cells in systemic lupus erythematosus.
- Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic Lupus erythematosus.
- Do tumor-necrosis-factor inhibitors prevent first cardiovascular events in patients with rheumatoid Arthritis?
- Plasminogen activator inhibitor-1 is associated with impaired endothelial function in women with systemic Lupus erythematosus.
- Women in academic rheumatology.
- Apoptosis in systemic Lupus erythematosus.
- Endothelial Cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity.
- Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T Cells.
- Effects of cilostazol in patients with Raynaud's Syndrome.
- Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of Disease.
- The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T Cells.
- The Peroxisome Proliferator Activated Receptor-γ Pioglitazone Improves Vascular Function and Decreases Disease Activity in Patients With Rheumatoid Arthritis.
- ExtraCellular chromatin traps interconnect Cell biology, microbiology, and immunology.
Schools
University of Kansas School of Medicine
University Of Mi Hosps and Health Ctrs
Procedures Preformed
- Joint Drainage
- Steroid Injection
- Trigger Point Injection
- Viscosupplementation With Hyaluronate
Conditions Treated
- Antiphospholipid Syndrome (APS)
- Arthritis
- Bursitis
- Carpal Tunnel Syndrome
- View All
Doctors Specialties
- Rheumatology
Accepted Insurances
- Aetna
- Amerigroup (Wellpoint)
- Blue Cross Blue Shield
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Golden Rule
- Health Alliance
- Medicaid
- Medicare MCR
- Molina
- NGS CoreSource
- PHP-Physicians Health Plan
- Tricare
- United Healthcare
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Fellow
- Fellow (FACR)
Education
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University of Michigan Hospitals and Health Centers -
Universidad Nacional Autonoma de Mexico
Hospital
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University of Michigan Hospitals and Health Centers
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