Professor, Anesthesiology, University of Pittsburgh School of Medicine
Anesthesiology
Dr. Margaret M. Tarpey, MD
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Margaret M. Tarpey is an expert in the field of Anesthesiology. She attended Duke University School of Medicine. Duke University School of Medicine is a one of the best medicals schools. Duke University School of Medicine has a rank of 8 in research and a 29 in primary care Margaret Tarpey is also a published MD. She has 36 paper published. The most recent paper is: Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries.
Publications
- Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production.
- Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats.
- Hydrogen peroxide is the major oxidant product of xanthine oxidase.
- Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase.
- Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.
- Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol.
- Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
- Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium.
- Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts.
- Sepiapterin treatment in atherosclerosis.
- Nitric oxide and reactive oxygen species in vascular injury.
- Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vas...
- Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension.
- Countdown to community care. Tomorrow's world.
- Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin.
- Evaluation of low-dose endotoxin administration during pregnancy as a model of preeclampsia.
- Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat.
- L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia.
- Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal.
- Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase.
- Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation.
- Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries.
- The mechanism of cardioprotection by S-nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest.
- Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.
- Oxygen radical-nitric oxide reactions in vascular diseases.
- Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.
- Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.
- Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis.
- Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide.
- S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide.
- Role of lymphatics in removal of sheep lung surfactant lipid.
- Partial monosomy 21, diminished activity of superoxide dismutase, and pulmonary oxygen toxicity.
- Uptake of alpha-ketoisocaproic acid in lymphoblast line WI-L2.
- Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease.
- Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite.
Schools
Duke University
North Carolina Memorial Hospital
Richland Meml Hospital
University Ala
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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University of North Carolina Hospitals -
Duke University School of Medicine
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