Professor of Medicine, University of Massachusetts Medical School
Infectious Disease
Dr. Margaret J. Koziel, MD
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Dr. Margaret J. Koziel practices Infectious Disease. He has 1 awards "Elected Member". Margaret Koziel is a published MD. He published 83 publications, including: 'Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.'
Publications
- VX-222, a non-nucleoside NS5B polymerase inhibitor, in telaprevir-based regimens for genotype 1 hepatitis C virus infection.
- Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C.
- Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.
- Incidence and predictors of acute kidney injury in an urban cohort of subjects with HIV and hepatitis C virus coinfection.
- Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection.
- Translational research in liver disease.
- Immune responses during acute and chronic infection with hepatitis C virus.
- Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.
- HIV and liver disease forum: conference proceedings.
- Viral hepatitis in HIV infection.
- Effect of exposure to injection drugs or alcohol on antigen-specific immune responses in HIV and hepatitis C virus coinfection.
- Effects of HCV treatment on cytokine expression during HCV/HIV coinfection.
- Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis.
- Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction.
- NK cells: natural born killers in the conflict between humans and HCV.
- Peginterferon alfa-2b therapy in acute hepatitis C: impact of onset of therapy on sustained virologic response.
- Impact of hepatitis C virus on immune restoration in HIV-infected patients who start highly active antiretroviral therapy: a meta-analysis.
- Cellular immune responses against hepatitis C virus.
- CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection.
- Prediction of relapse following treatment for hepatitis C: is whole blood more than the sum of its parts?
- Natural killer cells and hepatitis C: is losing inhibition the key to clearance?
- To be or not to be NKT: natural killer T cells in the liver.
- Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients.
- Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells.
- Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV.
- Pegylated interferon alpha therapy in acute hepatitis C: relation to hepatitis C virus-specific T cell response kinetics.
- Kinetics of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses in HCV and Schistosoma mansoni coinfection: relation to progression of liver fibrosis.
- Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection.
- Hepatitis C and alcohol: fundamental and translational research directions.
- First things first: balancing hepatitis C and human immunodeficiency virus.
- Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver.
- Insecticidal proteins from Bacillus thuringiensis protect corn from corn rootworms.
- Antiretroviral rounds. Three diseases, one patient.
- The dynamics of the immune response in acute hepatitis B: new lessons using new techniques.
- HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease.
- Specific cellular immune response and cytokine patterns in patients coinfected with hepatitis C virus and Schistosoma mansoni.
- Regulatory T cells and viral liver disease.
- Hepatitis C and human immunodeficiency virus envelope proteins cooperatively induce hepatocytic apoptosis via an innocent bystander mechanism.
- Acute hepatitis C without and with schistosomiasis: correlation with hepatitis C-specific CD4(+) T-cell and cytokine response.
- Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
- Molecular mechanism of hepatic injury in coinfection with hepatitis C virus and HIV.
- Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.
- Immune response to hepatitis B vaccine in HIV-infected subjects using granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant: ACTG study 5220.
- Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals.
- Characterization of HCV-Specific Cytotoxic T-Lymphocytes from Liver Tissue.
- Immunology of hepatitis C virus infection.
- Immunopathogenesis of hepatitis C virus in the immunosuppressed host.
- The immunopathogenesis of HBV infection.
- Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation.
- Cytokines in viral hepatitis.
- Hepatitis C virus genotypes and viremia and hepatocellular carcinoma in the United States.
- What once was lost, now is found: restoration of hepatitis B-specific immunity after treatment of chronic hepatitis B.
- Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.
- The role of immune responses in the pathogenesis of hepatitis C virus infection.
- Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons.
- Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection.
- DNA vaccines and viral hepatitis: are we going around in circles?
- Transgenic expression of hepatitis C virus structural proteins in the mouse.
- Hepatitis C virus and organ transplantation.
- Immunology of viral hepatitis.
- Vaccination against hepatitis C virus infection: miles to go before we sleep.
- Pulmonary complications of diabetes mellitus. Pneumonia.
- Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
- HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
- Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
- Viruses, chemotherapy and immunity.
- Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis.
- Why should hepatitis C affect immune reconstitution in HIV-1-infected patients?
- Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C).
- Antiviral T-cell responses and therapy in chronic hepatitis B.
- Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection.
- Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C.
- HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV.
- Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons.
- Structural proteins of Hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells.
- A tale of two viruses: hepatitis C in the age of HAART.
- Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection.
- Influence of HIV co-infection on hepatitis C immunopathogenesis.
- Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C.
- Viral factors associated with cytokine expression during HCV/HIV co-infection.
- Resolution of chronic hepatitis C following parasitosis.
- Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C.
Schools
Dartmouth College
Ne Deaconess
Mass General Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- First Health (Coventry Health Care) PPO
- MultiPlan PPO
- PHCS Network PPO
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Elected Member
Education
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Massachusetts General Hospital -
Beth Israel Deaconess Medical Center
Hospital
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UMass Memorial Medical Center
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