Physician
Anesthesiology
Dr. Marcus A. Jenkins, MD
Marcus Jenkins is an expert in the field of Anesthesiology. He went to University of Toledo College of Medicine. Marcus Jenkins is a published physician. He published 101 publications, including: 'Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect.'
Publications
- Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse.
- In vitro and in vivo correlates of hybrid tumor resistance.
- Prolonged survival without posttransplant immunosuppression in a large animal model.
- In vivo effects of GK1.5 (anti-L3T4a) monoclonal antibody on induction and expression of delayed-type hypersensitivity.
- Immunoregulatory pathways in adult responder mice. I. Induction of GAT-specific tolerance and suppressor T cells for cellular and humoral responses.
- Immunoregulatory pathways in adult responder mice. III. Establishment of a GAT-specific suppressor T cell clone from GAT-tolerant responders which afferently regulates...
- Immunoregulatory pathways in adult responder mice. II. Regulation of delayed-type hypersensitivity responses by GAT-specific suppressor factors present in GAT-tolerant...
- Mechanisms of genetic control of immune responses. II. Nonresponsiveness in BALB/c GT-specific cell-mediated immune responses does not correlate with the absence of fu...
- Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.
- Memory and anergy: challenges to traditional models of T lymphocyte differentiation.
- T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state.
- Murine lymphotactin: gene structure, post-translational modification and inhibition of expression by CD28 costimulation.
- Surface proteins involved in T cell costimulation.
- Costimulating factors and signals relevant for antigen presenting cell function.
- Accessory cell-derived signals required for T cell activation.
- nef-naf nexus?
- Isolation and characterization of an I-A-restricted T cell clone with dual specificity for poly(Glu60Ala30Tyr10) (GAT) and Mlsa,dl.
- Suppressor T cell circuits in contact sensitivity. III. A monoclonal T cell hybrid-derived suppressor factor specifically suppresses local DTH transfer by a DNP-specif...
- Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect.
- The role of cell division in the induction of clonal anergy.
- The role of anergy in peripheral T cell unresponsiveness.
- Co-stimulatory functions of antigen-presenting cells.
- Accumulation of sequence-specific RNA-binding proteins in the cytosol of activated T cells undergoing RNA degradation and apoptosis.
- A single amino acid substitution in a cytochrome c T cell stimulatory peptide changes the MHC restriction element from one isotype (I-Ak) to another (I-Ek).
- Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.
- Effects of cyclosporine A on T cell development and clonal deletion.
- The ups and downs of T cell costimulation.
- Autoimmunity: when self-tolerance breaks down.
- Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1.
- Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions.
- Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity.
- Molecules involved in T-cell costimulation.
- Accessory cell-derived costimulatory signals regulate T cell proliferation.
- Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium.
- Visualization of specific B and T lymphocyte interactions in the lymph node.
- The anatomy of T-cell activation and tolerance.
- Clonal expansion of antigen-specific CD4 T cells following infection with Salmonella typhimurium is similar in susceptible (Itys) and resistant (Ityr) BALB/c mice.
- The murine immune response to the male-specific antigen mouse testicular cytochrome c.
- Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells.
- Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.
- IL-2 secretion and T cell clonal anergy are induced by distinct biochemical pathways.
- Studying immunological tolerance by physically monitoring antigen-specific T cells in vivo.
- A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenti...
- Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy.
- Molecular mechanisms underlying functional T-cell unresponsiveness.
- Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction.
- Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific Th1 clones.
- Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen.
- Induction and maintenance of anergy in mature T cells.
- Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
- A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.
- Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.
- Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice.
- Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect.
- T-cell clonal anergy.
- Visualizing the generation of memory CD4 T cells in the whole body.
- Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo.
- Revealing the in vivo behavior of CD4+ T cells specific for an antigen expressed in Escherichia coli.
- Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.
- An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiv...
- Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.
- Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
- Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy.
- Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host.
- Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium.
- Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells.
- Peripheral immune tolerance blocks clonal expansion but fails to prevent the differentiation of Th1 cells.
- Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.
- A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism.
- Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.
- In vivo detection of dendritic cell antigen presentation to CD4(+) T cells.
- Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo.
- Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
- An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal.
- CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.
- Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.
- The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.
- Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells.
- In vivo activation of antigen-specific CD4 T cells.
- Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance.
- CD154+ graft antigen-specific CD4+ T cells are sufficient for chronic rejection of minor antigen incompatible heart grafts.
- Temporal expression of bacterial proteins instructs host CD4 T cell expansion and th17 development.
- Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells.
- Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.
- Robust antigen specific th17 T cell response to group A Streptococcus is dependent on IL-6 and intranasal route of infection.
- Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.
- Origins of CD4(+) effector and central memory T cells.
- On the trail of arthritogenic T cells.
- CD4+ memory T cell survival.
- Different B cell populations mediate early and late memory during an endogenous immune response.
- Distinct functions of antigen-specific CD4 T cells during murine Mycobacterium tuberculosis infection.
- Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations.
- CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia.
- On the composition of the preimmune repertoire of T cells specific for Peptide-major histocompatibility complex ligands.
- A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens.
- Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
- Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire.
- Tracking epitope-specific T cells.
- Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin.
- Imaging the immune system.
Schools
University Of Toledo
St Francis Med Center
Hahnemann University Hospital
Thomas Jefferson University Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
- Amerigroup (Wellpoint)
- Cigna
- Coventry Health Care
- Medicare MCR
- Scion Dental
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Education
-
Thomas Jefferson University -
University of Toledo College of Medicine
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