Professor, Microbiology, University of Virginia School of Medicine

Pediatrics

Marcia J. McDuffie, MD works in the field of Pediatrics. Marcia J. McDuffie is also published. She has 49 publications published. The lastest publication: "Genetics of autoimmune diabetes in animal models.'

Publications

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• Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development.
• Manganese-Enhanced Magnetic Resonance Imaging Detects Declining Pancreatic β-Cell Mass in a Cyclophosphamide-Accelerated Mouse Model of Type 1 Diabetes.
• Phospholemman Deficiency in Postinfarct Hearts: Enhanced Contractility but Increased Mortality.
• Spontaneous Autoimmune Gastritis and Hypochlorhydria are Manifest in the Ileitis-Prone SAMP1/YitFcs Mice.
• Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.
• Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice.
• Cutting edge: genetic characterization of IFN-producing killer dendritic cells.
• GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic (NOD) mouse myeloid cells.
• Age-dependent tolerance to an endogenous tumor-associated antigen.
• Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.
• The Runx3 distal transcript encodes an additional transcriptional activation domain.
• Truncated pStat5B is associated with the Idd4 locus in NOD mice.
• Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.
• Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis.
• Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice.
• Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene.
• Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.
• Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice.
• Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage...
• Viral IL-10-mediated immune regulation in pancreatic islet transplantation.
• Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn''s disease.
• Autoimmune diabetes is blocked in Stat4-deficient mice.
• Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction.
• Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis.
• Role for oxidative stress in the regeneration of islet beta cells?
• Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.
• Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene.
• Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc.
• Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis.
• The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice.
• Suppression of autoimmune diabetes by viral IL-10 gene transfer.
• NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.
• Contractile properties and proteins of smooth muscles of a calponin knockout mouse.
• Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse.
• Genetics of autoimmune diabetes in animal models.
• A diabetes-associated T-cell autoantigen maps to a telomeric locus on mouse chromosome 6.
• Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice.
• The accessory molecule Lgp55 plays a role early in murine fetal thymocyte differentiation.
• Superantigen-like effects and incidence of diabetes in NOD mice.
• T-cell repopulation following neonatal injection of non-obese diabetic (NOD) mice with anti-T-cell antibodies.
• I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.
• Diabetes in NOD mice does not require T lymphocytes expressing V beta 8 or V beta 5.
• Antigen presentation and effector mechanisms in ''auto-immune'' diabetes.
• Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone.
• Identification of a new cell surface glycoprotein with accessory function in murine T cell responses.
• Effect of cyclosporine on immunologically mediated diabetes in nonobese diabetic mice.
• Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking.
• Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice.

Schools

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• University of North Carolina At Chapel Hill

• University Colo Health Science Center

• National Jewish Hospital

Doctors Specialties

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• Pediatrics

Accepted Insurances

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