Professor of Ophthalmology, Boston Children's Hospital
Ophthalmology
Dr. Lois E. Smith, MD
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Lois Smith is an expert in the field of Ophthalmology. She graduated from Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care She has 36 awards "Distinguished Lecturer", "Dr. Ramadan Distinguished Lecturer", "Distinguished Speaker Series", "Achievement Award", "Distinguished Visiting Lecturer", "Silverman Award", "Gold Medal", "2010 Joseph M Bryan Lecturer", "Silver Medal", "Research to Prevent Blindness Senior Investigator Award", "NIH Director WALS lecturer for outstanding contributions to science", "The Friedenwald Award for outstanding research in the basic or clinical sciences as applied to ophthalmology", "Cless Best of the Best Lecture", "Award for outstanding contributions to ophthalmic research", "Alfred W. Bressler Prize in Vision Science", "J. Donald Gass M.D. Memorial Lecture", "Best Doctors in America (peer elected)", "RPB Lew Wasserman Merit Award", "Alcon Visiting Professor and City Wide Rounds Lecturer", "Lloyd Morgan Lecturer", "Dr. John Fangman Lectureship, and Visiting Professor", "2004 Rich Lecturer", "2002 Deborah Iverson, M.D. Memorial Lecturer and visiting professor", "Research Award 2001 for work in Retinopathy of Prematurity", "2000 Roger Johnson Lecturer and Visiting Professor", "1997 Merck Senior Fellows Award", "Distinguished Ophthalmologist and Visiting Professor", "Research Fellow in Ophthalmology", "Fellow in Pediatric Ophthalmology", "Heed Ophthalmic Foundation Fellowship", "Summer Research Fellow", "Alpha Omega Alpha Honor Society", "IBM Graduate Research Fellow", "Woodrow Wilson Special Research Fellow", "Postgraduate Fellowship" and "Predoctoral Research Fellow". Lois E. Smith, MD has written publications. She has 67 publications published with PubMed. The lastest publication is: 'Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.'
Publications
- Prospective study of infantile hemangiomas: Incidence, clinical characteristics, and association with placental anomalies.
- Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.
- Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration.
- DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ?-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associate...
- Author response: different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mous...
- LRP5 Regulates Development of Lung Microvessels and Alveoli through the Angiopoietin-Tie2 Pathway.
- Importance of Early Postnatal Weight Gain for Normal Retinal Angiogenesis in Very Preterm Infants: A Multicenter Study Analyzing Weight Velocity Deviations for the Pre...
- Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy.
- Current update on retinopathy of prematurity: screening and treatment.
- Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR.
- Retinopathy of prematurity: current concepts in molecular pathogenesis.
- Adipose tissue growth and regression are regulated by angiopoietin-1.
- Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin.
- Analysis of candidate genes for macular telangiectasia type 2.
- Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice.
- 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of Ï-3 polyunsaturated fatty acids.
- Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.
- Lipid metabolites in the pathogenesis and treatment of neovascular eye Disease.
- Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a.
- Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation.
- Wnt signaling mediates pathological vascular growth in proliferative retinopathy.
- Retinal expression of wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (lrp5) knockout mice.
- Emerging treatments for retinopathy of prematurity.
- Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I.
- Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis.
- Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity.
- The mouse retina as an angiogenesis model.
- High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.
- Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy.
- SIRT1 is essential for normal cognitive function and synaptic plasticity.
- Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema.
- Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion.
- Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy.
- An eye for discovery.
- Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy.
- Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy.
- Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice.
- A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants.
- A mechanosensitive transcriptional mechanism that controls angiogenesis.
- Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity.
- Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth.
- RP-forme fruste.
- Molecular profiling of angiogenesis markers.
- Stem cells go for the eyes.
- Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo.
- Pathogenesis of retinopathy of prematurity.
- Can we restore aspects of the in utero environment in premature infants to prevent Disease?
- Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa.
- Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells.
- Quantitative multi-gene transcriptional profiling using real-time PCR with a master template.
- Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.
- IGF-1 and retinopathy of prematurity in the preterm infant.
- A radically twisted lipid regulates vascular death.
- Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California).
- Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor-1 deficit.
- Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity.
- Retinopathy of prematurity.
- IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
- Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis.
- Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration.
- Erythropoietin deficiency decreases vascular stability in mice.
- A double-edged sword: erythropoietin eyed in retinopathy of prematurity.
- Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture.
- Choroid sprouting assay: an ex vivo model of microvascular angiogenesis.
- Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.
- Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
Schools
Boston University School Of Medicine
Beth Israel Hospital Harvard
Mass Ee Infirm Harvard
Chldns Hospital Harvard
Conditions Treated
- Cataract
- Esotropia
- Exotropia
- Lazy Eye
- View All
Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- Distinguished Lecturer
- Dr. Ramadan Distinguished Lecturer
- Distinguished Speaker Series
- Achievement Award
- Distinguished Visiting Lecturer
- Silverman Award
- Gold Medal
- 2010 Joseph M Bryan Lecturer
- Silver Medal
- Research to Prevent Blindness Senior Investigator Award
- NIH Director WALS lecturer for outstanding contributions to science
- The Friedenwald Award for outstanding research in the basic or clinical sciences as applied to ophthalmology
- Cless Best of the Best Lecture
- Award for outstanding contributions to ophthalmic research
- Alfred W. Bressler Prize in Vision Science
- J. Donald Gass M.D. Memorial Lecture
- Best Doctors in America (peer elected)
- RPB Lew Wasserman Merit Award
- Alcon Visiting Professor and City Wide Rounds Lecturer
- Lloyd Morgan Lecturer
- Dr. John Fangman Lectureship, and Visiting Professor
- 2004 Rich Lecturer
- 2002 Deborah Iverson, M.D. Memorial Lecturer and visiting professor
- Research Award 2001 for work in Retinopathy of Prematurity
- 2000 Roger Johnson Lecturer and Visiting Professor
- 1997 Merck Senior Fellows Award
- Distinguished Ophthalmologist and Visiting Professor
- Research Fellow in Ophthalmology
- Fellow in Pediatric Ophthalmology
- Heed Ophthalmic Foundation Fellowship
- Summer Research Fellow
- Alpha Omega Alpha Honor Society
- IBM Graduate Research Fellow
- Woodrow Wilson Special Research Fellow
- Postgraduate Fellowship
- Predoctoral Research Fellow
Education
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Harvard University -
Boston Children's Hospital -
Massachusetts Eye & Ear Infirmary -
Beth Israel Deaconess Medical Center -
Boston University School of Medicine
Hospital
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Boston Children's Hospital -
Massachusetts Eye and Ear Infirmary
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