Professor at Southern Illinois University School of Medicine
Otolaryngology (ENT)
Dr. Leonard P. Rybak, MD
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Dr. Leonard P. Rybak is an expert in the field of Otolaryngology (ENT). He went to medical school at Medical College of Wisconsin. Medical College of Wisconsin is ranked 54/62 in Research/PrimaryCare. He received awards:"Fellow (FACS)" and "Fellow (FAAO-HNS)". Leonard Rybak has written publications. He has 99 publications published with PubMed. The lastest paper is: 'A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis.' Leonard P. Rybak, MD accepts Medicare payments and is registered with Medicare.gov.
Publications
- Early investigational drugs for hearing loss.
- Essential Role of NADPH Oxidase-Dependent Reactive Oxygen Species Generation in Regulating MicroRNA-21 Expression and Function in Prostate Cancer.
- Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway.
- siRNA-Mediated knock-down of NOX3: therapy for hearing loss?
- The design and screening of drugs to prevent acquired sensorineural hearing loss.
- NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-Mediated inflammation and hearing loss.
- Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat.
- Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery.
- Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.
- Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase.
- Mechanisms of cisplatin ototoxicity and progress in otoprotection.
- Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats.
- Noise in animal facilities: why it matters.
- Activation of the adenosine A3 receptor in RAW 264.7 cells inhibits lipopolysaccharide-stimulated tumor necrosis factor-alpha release by reducing calcium-dependent act...
- Partial protection by lipoic acid against carboplantin-induced ototoxicity in rats.
- Neurochemistry of the peripheral and central auditory system after ototoxic drug exposure: implications for tinnitus.
- Osmotic diuretics induce adenosine A1 receptor expression and protect renal proximal tubular epithelial cells against cisplatin-Mediated apoptosis.
- Vitamin E reduces cisplatin ototoxicity.
- Ototoxicity: bioprotective mechanisms.
- Round window application of D-methionine provides complete cisplatin otoprotection.
- TRPV1: A Potential Drug Target for Treating Various Diseases.
- Adenosine receptors: expression, function and regulation.
- Baclofen reduces tone-evoked activity of cochlear nucleus neurons.
- Effect of furosemide upon endolymph potassium concentration.
- Nature of blood-labyrinth barrier in experimental conditions.
- Endocochlear potential and potassium concentration in endolymph and perilymph of the chinchilla.
- Pathophysiology of furosemide ototoxicity.
- Developmental ototoxicity.
- Ototoxicity in developing mammals.
- Drug ototoxicity.
- Air caloric testing in Otitis media. (preliminary studies).
- Pharmacokinetics of furosemide in relation to the alteration of endocochlear potential.
- Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney.
- Tympanic membrane perforations from water sports: treatment and outcome.
- Medical treatment of Chronic sinusitis in the immunocompetent and immunosuppressed patient: a review.
- "How I do it"--otology and neurotology. A specific issue and its solution: perilymph fistula.
- Once-a-day therapy for Sinusitis: a comparison study of cefixime and amoxicillin.
- Eye tracking abnormalities in patients with cerebrovascular Disease.
- The development of antibiotic resistant organisms with the use of ototopical medications.
- Treatable sensorineural hearing loss.
- Severe otolaryngologic manifestations of arthrogryposis multiplex congenita.
- Correlative evidence of hypertension and altered cochlear microhomeostasis: electrophysiological changes in the spontaneously hypertensive rat.
- Inhibition of glutathione-related enzymes and cytotoxicity of ethacrynic acid and cyclosporine.
- Primary B-cell lymphoma of the clivus: case report.
- Olfactory mucosal lesions following subcutaneous diethyldithiocarbamate (DDTC).
- Pediatric laryngeal sarcoidosis.
- Organic acid transport into the cochlear perilymph.
- Obstructing nasopharyngeal teratoma in the neonate. A report of two cases.
- Applications of hyperbaric oxygen for the otolaryngologist--Head and neck surgeon.
- Ototoxicity of ethacrynic acid (a persistent clinical problem).
- Comparative efficacy of aminoglycoside versus fluoroquinolone topical antibiotic drops.
- Interaction of methylprednisolone and transient asphyxia on the inner ear of the adrenalectomized rat.
- Ototoxicity of ototopical antibiotic drops in humans.
- Pharmacologic determinants of ototoxicity of furosemide in the chinchilla.
- Probenecid reduces cochlear effects and perilymph penetration of furosemide in chinchilla.
- Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects.
- Metabolic disorders of the vestibular system.
- Furosemide ototoxicity: clinical and experimental aspects.
- Ototoxicity of loop diuretics.
- The ototoxicity of deferoxamine mesylate.
- Metastatic thymoma to the Head and neck.
- Hearing: the effects of chemicals.
- A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis.
- Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells.
- Some organic acids attenuate the effects of furosemide on the endocochlear potential.
- Quantification of furosemide from serum and tissues using high-performance liquid chromatography.
- Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics.
- Changes in endolymph chloride concentration following furosemide injection.
- Noninvasive electrodes for electrocochleography in the chinchilla.
- Combined effects of adrenalectomy and noise exposure on compound action potentials, endocochlear potentials and endolymphatic potassium concentrations.
- An experimental study using sodium salicylate to reduce cochlear changes induced by furosemide.
- Cochlear effects of locally applied inhibitors.
- Comparative ototoxicity of furosemide and piretanide.
- Ototoxicity: therapeutic opportunities.
- Development of the stria vascularis in the rat.
- Effects of organic acids on the edema of the stria vascularis induced by furosemide.
- Dose-response relationships for furosemide ototoxicity in rat.
- Kinocilia in the developing stria vascularis of the rat pup.
- Adenosine, antioxidant enzymes and cytoprotection.
- Carboplatin-induced oxidative stress in rat cochlea.
- Consensus panel on role of potentially ototoxic antibiotics for topical middle ear use: Introduction, methodology, and recommendations.
- Effects of topical sodium potassium ATPase inhibitors upon endocochlear potential in chinchilla.
- Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model.
- Quinine reduces noxious cochlear effects of furosemide and ethacrynic acid.
- Alteration of 6-phosphofructo-1-kinase subunits during neonatal maturation of the rat cochlear cells.
- Effects of organic acids on stria vascularis ultrastructure and function in the chinchilla.
- D-Methionine protects against cisplatin damage to the stria vascularis.
- Comparative acute ototoxicity of loop diuretic compounds.
- Potentiation of ototoxicity by glutathione depletion.
- Development of endocochlear potential and compound action potential in the rat.
- Ototoxicity of indacrinone is stereospecific.
- Organic acids do not alter the cochlear effects of ethacrynic acid.
- Cochlear effects of indacrinone are not altered by penicillin.
- Acute changes in cochlear potentials due to cisplatin.
- D-methionine provides excellent protection from cisplatin ototoxicity in the rat.
- Mechanisms of cisplatin-induced ototoxicity and prevention.
- The effect of combined administration of cadmium and furosemide on auditory function in the rat.
- Pharmacological antagonism of the slow-activating delayed rectifying potassium channel (I(Ks)) has no effect on cochlear structure and function in vivo.
Schools
Medical College of Wisconsin
Hennepin Co Genl
University Of Minnesota
Procedures Preformed
- Ablation or Excision of Nasal Turbinates
- Antrostomy and Antrotomy (Sinus Surgery)
- Ear Tube Placement
- Ethmoidectomy (Sinus Surgery)
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Conditions Treated
- Acoustic Neuroma
- Allergic Rhinitis
- Bell's Palsy
- Cholesteatoma
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Doctors Specialties
- Ear, Nose, and Throat
- Otolaryngology (ENT)
Accepted Insurances
Awards
- Fellow (FACS)
- Fellow (FAAO-HNS)
Education
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University of Minnesota at Fairview -
Hennepin County Medical Center -
Medical College of Wisconsin
Hospital
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St. John's Hospital
Drug Facts
| NPI NUMBER | 1194710913 | |
| NPPES Provider LastName | RYBAK | |
| NPPES Provider FirstName | LEONARD | |
| NPPES Provider ZIPCode | 627026700 | |
| NPPES Provider State | IL | |
| Specialty Description | Otolaryngology | |
| Total Claim Count | 109.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1194710913 |
| Last Name Of The Provider | RYBAK |
| First Name Of The Provider | LEONARD |
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