Professor, Pediatrics, Children's Hospital, Harvard Medical School
Hematology
Dr. Leonard I. Zon, MD
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Leonard practices Hematology. He attended Jefferson Medical College. He received 3 awards: "Elected Member", "Investigator" and "Whos Who in Medicine and Healthcare". Dr. Leonard I. Zon is also a published MD. He has 98 paper published. The most recent paper is: Screening for melanoma resistance genes in vivo.
Publications
- A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish.
- Screening for melanoma resistance genes in vivo.
- Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.
- A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.
- Getting more for your marrow: Boosting hematopoietic stem cell numbers with PGE2.
- A comparison of non-integrating reprogramming methods.
- Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).
- Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin.
- Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multi-case Diamond-Blackfan anemia families.
- Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.
- Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation.
- Translational research: the path for bringing discovery to patients.
- Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.
- Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish.
- Of fish and men: using zebrafish to fight human diseases.
- A network of epigenetic regulators guides developmental haematopoiesis in vivo.
- zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish.
- A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species.
- The zebrafish granulocyte colony stimulating factors (Gcsfs): two paralogous cytokines and their roles in hematopoietic development and maintenance.
- Zebrafish cancer: the state of the art and the path forward.
- Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system.
- Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
- Assaying hematopoiesis using zebrafish.
- Zebrafish rhabdomyoSarcoma reflects the developmental stage of oncogene expression during myogenesis.
- Hematopoiesis.
- A Model for Primary Melanoma of the CNS Implicates NRAS.
- Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.
- Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.
- TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
- The transcriptional landscape of hematopoietic stem cell ontogeny.
- Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting.
- CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.
- Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.
- Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR.
- Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway.
- Linking hematopoietic regeneration to developmental signaling pathways: A story of BMP and Wnt.
- Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis.
- Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model.
- An optical platform for cell tracking in adult zebrafish.
- Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation.
- Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration.
- Stromal cell-derived factor-1 (SDF-1) and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplant.
- Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors.
- Characterization of immune-matched hematopoietic transplantation in zebrafish.
- cpsf1 is required for definitive HSC survival in zebrafish.
- Prostaglandin e2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.
- Modeling Diamond Blackfan anemia in the zebrafish.
- Clonal analysis of hematopoietic progenitor cells in the zebrafish.
- The ERGonomics of hematopoietic stem cell self-renewal.
- Transplantation in zebrafish.
- Chemical screening in zebrafish for novel biological and therapeutic discovery.
- Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments.
- Genetic suppressor screens in haploids.
- Chromatin immunoprecipitation in adult zebrafish red cells.
- The zon laboratory guide to positional cloning in zebrafish.
- Stem Cell Migration: A Zebrafish Model.
- The zebrafish. Preface.
- A new system for the rapid collection of large numbers of developmentally staged zebrafish embryos.
- T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
- PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.
- Zebrafish models of p53 functions.
- Fishing at the cellular level.
- Interaction of retinoic acid and scl controls primitive blood development.
- TIF1gamma controls erythroid cell fate by regulating transcription elongation.
- Newly emerging roles for prostaglandin E2 regulation of hematopoiesis and hematopoietic stem cell engraftment.
- High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.
- The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
- Resolving the controversy about N-cadherin and hematopoietic stem cells.
- A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis.
- The new age of chemical screening in zebrafish.
- Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.
- Melanocytes in development and cancer.
- Small molecule screen in zebrafish and HSC expansion.
- The zebrafish: cellular and developmental biology, part A. Preface.
- Zebrafish tumor assays: the state of transplantation.
- Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.
- Zebrafish blood stem cells.
- Zebrafish kidney stromal cell lines support multilineage hematopoiesis.
- Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.
- A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.
- Hematopoietic stem cell development is dependent on blood flow.
- Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
- Transferrin-a modulates hepcidin expression in zebrafish embryos.
- Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.
- Construction and application of a zebrafish array comparative genomic hybridization platform.
- Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells.
- Defining cancer stem cells by xenotransplantation in zebrafish.
- The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio.
- Melanoma biology and the promise of zebrafish.
- Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2.
- Melanocytes in development, regeneration, and cancer.
- Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen.
- APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.
- Self-renewal and differentiation at Cell Stem Cell.
- Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE).
- SnapShot: hematopoiesis.
- Hematopoiesis: an evolving paradigm for stem cell biology.
Schools
Thomas Jefferson University
New Eng Deaconess Hospital
Dana Farber Canc Institute
Conditions Treated
- Soft Tissue Sarcoma
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- Elected Member
- Investigator
- Whos Who in Medicine and Healthcare
Education
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Beth Israel Deaconess Medical Center -
Jefferson Medical College
Hospital
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Boston Children's Hospital -
Dana-Farber Cancer Institute
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