Clinical Associate Professor, Pediatrics, Baylor College of Medicine
Pediatrics
Dr. Leon Freedman, MD
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Leon Freedman, MD is an expert in the field of Pediatrics. He attended Baylor College of Medicine. He over the years received 3 awards: "Patient-Centered Medical Home Recognition Program", "Super Doctor" and "Fellow (FAAP)". Leon Freedman is a published doctor. He published 101 publications, including: 'Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation.'
Publications
- Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes.
- Identification of 5?, 6?-epoxycholesterol as a novel modulator of liver X receptor activity.
- Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic ...
- Estrogen receptor beta is a novel therapeutic target for photoaging.
- Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and inducti...
- Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination.
- The skinny on fat: how oxysterols may regulate functional glucocorticoids in adipose tissue.
- Liver X receptor is a therapeutic target for photoaging and chronological skin aging.
- MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways.
- Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.
- Signaling by estrogens.
- A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.
- Selective androgen receptor modulators for frailty and osteoporosis.
- Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.
- Vitamin D receptor ligands for osteoporosis.
- Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy.
- Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy.
- Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
- Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.
- Direct agonist/antagonist functions of dehydroepiandrosterone.
- Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
- The evidence for emergency obstetric care.
- Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.
- The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates.
- Selective coactivator interactions in gene activation by SREBP-1a and -1c.
- Identification of DRIP205 as a coactivator for the Farnesoid X receptor.
- Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.
- The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.
- A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
- Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation.
- Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.
- Steroid hormone receptors and drug discovery: therapeutic opportunities and assay designs.
- Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation.
- Human rights, constructive accountability and maternal mortality in the Dominican Republic: a commentary.
- Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.
- Role of metazoan mediator proteins in interferon-responsive transcription.
- Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205.
- Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor.
- A coactivator code for transcription.
- Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting prot...
- 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells.
- The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937...
- Using human rights in maternal mortality programs: from analysis to strategy.
- Mediator complexes and transcription.
- Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.
- Molecular analysis of the prostate-specific antigen upstream gene enhancer.
- Identification and characterization of two androgen response regions in the human neutral endopeptidase gene.
- Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.
- p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells.
- Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.
- Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex.
- Knowledge and willingness to use emergency contraception among low-income post-partum women.
- Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme.
- Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.
- The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.
- A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
- Nuclear receptor cofactors as chromatin remodelers.
- Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.
- Coactivators for the orphan nuclear receptor RORalpha.
- 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.
- A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DN...
- Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.
- Induced differentiation of U937 cells by 1,25-dihydroxyvitamin D3 involves cell cycle arrest in G1 that is preceded by a transient proliferative burst and an increase ...
- Increasing the complexity of coactivation in nuclear receptor signaling.
- Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation.
- Strategies for transcriptional activation by steroid/nuclear receptors.
- Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation.
- A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.
- Granulocyte-macrophage colony-stimulating factor gene transcription is directly repressed by the vitamin D3 receptor. Implications for allosteric influences on nuclear...
- A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.
- Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription.
- DNA bending is induced by binding of the glucocorticoid receptor DNA binding domain and progesterone receptors to their response element.
- Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation.
- Identification of a vitamin D3-response element that overlaps a unique inverted TATA box in the rat bone sialoprotein gene.
- AP-1 regulation of the rat bone sialoprotein gene transcription is mediated through a TPA response element within a glucocorticoid response unit in the gene promoter.
- Modulation of nuclear receptor interactions by ligands: kinetic analysis using surface plasmon resonance.
- Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
- Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.
- Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3.
- Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
- Nuclear receptors. Dymer, dymer binding tight.
- Glucocorticoid regulation of bone sialoprotein (BSP) gene expression. Identification of a glucocorticoid response element in the bone sialoprotein gene promoter.
- Regulation of bone sialoprotein gene transcription by steroid hormones.
- Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors.
- Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.
- DNA sequences that act as high affinity targets for the vitamin D3 receptor in the absence of the retinoid X receptor.
- The steroid/nuclear receptors: from three-dimensional structure to complex function.
- DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.
- Delineation of a DNA recognition element for the vitamin D3 receptor by binding site selection.
- On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective.
- Human rights and reproductive choice.
- Anatomy of the steroid receptor zinc finger region.
- DNA binding analysis of glucocorticoid receptor specificity mutants.
- DNA binding properties of the vitamin D3 receptor zinc finger region.
- Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.
- Cadmium-113 NMR studies of the DNA binding domain of the mammalian glucocorticoid receptor.
- 1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements.
- Solution structure of the glucocorticoid receptor DNA-binding domain.
- Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor.
- Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.
Schools
New York Medical College
Baylor College Of Med
Doctors Specialties
- Pediatrics
Accepted Insurances
Awards
- Patient-Centered Medical Home Recognition Program
- Super Doctor
- Fellow (FAAP)
Education
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Baylor College of Medicine -
New York Medical College
Hospital
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Texas Children's Hospital -
Memorial Hermann Memorial City Medical Center
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