Professor, Internal Medicine, Ohio State University College of Medicine
Endocrinology
Dr. Lawrence S. Kirschner, MD
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Lawrence S. Kirschner works in the field of Endocrinology. He researched medicine at Albert Einstein College of Medicine of Yeshiva University. He over the years received 2 awards: "Regional Top Doctor" and "CMS Meaningful Use Stage 1 Certification". Lawrence Kirschner is a published doctor. He has 82 publications published. The most current publication "Characterization of the adrenal gland pathology of Carney complex, and molecular genetics of the disease." Lawrence Kirschner is registered with Medicare and accepts Medicare payments.
Publications
- Mouse models of Thyroid cancer: A 2015 update.
- 5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.
- BRAF activates and physically interacts with PAK to regulate cell motility.
- Medicine. A unified cause for Adrenal Cushing's syndrome.
- Knockdown of PRKAR1A, the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells.
- Follicular Thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by Thyroid specific deletion of Prkar1a and Pten in mice.
- The Protein Kinase A Regulatory Subunit R1A (Prkar1a) Plays Critical Roles in Peripheral Nerve Development.
- Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell Tumors.
- The next generation of therapies for adrenocortical Cancers.
- Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperThyroidism and follicular Thyroid cancer.
- Targeted therapies for adrenocortical carcinoma: IGF and beyond.
- Differential role of PKA catalytic subunits in mediating phenoTypes caused by knockout of the Carney complex gene Prkar1a.
- Snapin mediates incretin action and augments glucose-dependent insulin secretion.
- Prkar1a is an osteosarcoma Tumor suppressor that defines a molecular subclass in mice.
- Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification.
- Cushing's syndrome and fetal features resurgence in Adrenal cortex-specific Prkar1a knockout mice.
- Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
- Clinical and genetic heterogeneity, overlap with other tumor Syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular a...
- Mutations in regulatory subunit Type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenoType analysis in 353 patients and 80 different ge...
- The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
- Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
- Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
- Mutation of Prkar1a causes osteoblast Neoplasia driven by dysregulation of protein kinase A.
- Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary Tumorigenesis.
- Development of a pituitary-specific cre line targeted to the Pit-1 lineage.
- 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase.
- Editorial: paradigms for Adrenal cancer: think globally, act locally.
- A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.
- Emerging treatment strategies for adrenocortical carcinoma: a new hope.
- Disruption of protein kinase a regulation causes immortalization and dysregulation of D-Type cyclins.
- A mouse model for the Carney complex tumor Syndrome develops neoplasia in cyclic AMP-responsive tissues.
- Down-regulation of regulatory subunit Type 1A of protein kinase A leads to endocrine and other tumors.
- A mouse model for Carney complex.
- Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical Tumors: 17q losses, somatic mutations, and protein kinase A expression...
- Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodula...
- Protein kinase A and Tumorigenicity: the example of micronodular adrenocortical hyperplasia and Carney complex.
- Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic Thyroid cancer.
- Signaling pathways in adrenocortical Cancer.
- Protein Kinase A Activation Enhances β-Catenin Transcriptional Activity through Nuclear Localization to PML Bodies.
- PRKAR1A and the evolution of pituitary Tumors.
- Mouse models of Endocrine tumours.
- Mouse models of altered protein kinase A signaling.
- Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.
- Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
- Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.
- Gene array analysis of macronodular Adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators.
- Sequence analysis of the PRKAR1A gene in sporadic somatotroph and Other pituitary tumours.
- Spectrum of mutations of the AAAS gene in Allgrove Syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.
- Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation.
- Isolated familial somatotropinomas: does the disease map to 11q13 or to 2p16?
- Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.
- Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy.
- Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, Endocrine overactivity and sch...
- Mutations of the gene encoding the protein kinase A Type I-alpha regulatory subunit in patients with the Carney complex.
- Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes.
- Neurosurgical implications of Carney complex.
- Genomic mapping of chromosomal region 2p15-p21 (D2S378-D2S391): integration of Genemap'98 within a framework of yeast and bacterial artificial chromosomes.
- Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease.
- Large-scale preparation of sequence-ready bacterial artificial chromosome DNA using QIAGEN columns.
- Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16.
- Adipose S14 mRNA is Abnormally regulated in obese subjects.
- Radiation hybrid mapping of chromosomal region 2p15-p16: integration of expressed and polymorphic sequences maps at the Carney complex (CNC) and Doyne honeycomb retina...
- Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroEndocrine properties of tumors associated with Carney complex.
- Characterization of the Adrenal gland pathology of Carney complex, and molecular genetics of the disease.
- Identification of a novel genetic locus for familial cardiac myxomas and Carney complex.
- Carney complex: diagnosis and management of the complex of spotty skin pigmentation, myxomas, Endocrine overactivity, and schwannomas.
- Carney complex, Peutz-Jeghers Syndrome, Cowden disease, and Bannayan-Zonana Syndrome share cutaneous and endocrine manifestations, but not genetic loci.
- Clinical and genetic analysis of primary bilateral Adrenal diseases (micro- and macronodular disease) leading to Cushing syndrome.
- P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for exon-1 after Epstein-Barr virus transformation.
- The aromatase excess Syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.
- Management of a giant fluid-filled bulla by closed-chest thoracostomy tube drainage.
- Localization of sequences that influence basal and cell Type-specific activity of the murine mdr2 promoter.
- De novo generation of simple sequence during gene amplification.
- Amplification of the murine mdr2 gene and a reconsideration of the structure of the murine mdr gene locus.
- Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.
- Biochemical and genetic characterization of the multidrug resistance phenoType in murine macrophage-like J774.2 cells.
- PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex.
- Chromosome 2 (2p16) Abnormalities in Carney complex tumours.
- Mouse model for bilateral Adrenal hyperplasia.
- A transgenic mouse bearing an antisense construct of regulatory subunit Type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney comple...
- Use of mouse models to understand the molecular basis of tissue-specific Tumorigenesis in the Carney complex.
Schools
Albert Einstein College of Medicine of Yeshiva University
University Of Minnesota Med Center
Conditions Treated
- Abnormal Thyroid
- Acromegaly and Gigantism
- Adrenal Incidentaloma
- Adrenal Insufficiency
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Regional Top Doctor
- CMS Meaningful Use Stage 1 Certification
Education
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National Institutes of Health Clinical Center -
Albert Einstein College of Medicine of Yeshiva University
Hospital
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Ohio State University Wexner Medical Center
Drug Facts
| NPI NUMBER | 1265449433 | |
| NPPES Provider LastName | KIRSCHNER | |
| NPPES Provider FirstName | LAWRENCE | |
| NPPES Provider ZIPCode | 432101240 | |
| NPPES Provider State | OH | |
| Specialty Description | Endocrinology | |
| Total Claim Count | 346.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1265449433 |
| Last Name Of The Provider | KIRSCHNER |
| First Name Of The Provider | LAWRENCE |
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