Physician

Obstetrics & Gynecology

Lawrence C. Layman practices Obstetrics & Gynecology. He attended Medical College of Georgia. He has 2 awards "Regional Top Doctor" and "Fellow (FACOG)". Lawrence Layman is a published doctor. He published 87 publications, including: 'Mutations in human gonadotropin genes and their physiologic significance in puberty and reproduction.' Lawrence C. Layman, MD accepts all Medicare patients.

Publications

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• NELF knockout is associated with impaired pubertal development and subfertility.
• The Expression of the miR-25/93/106b Family of Micro-RNAs in the Adipose Tissue of Women With Polycystic Ovary Syndrome.
• Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids.
• The historical Coffin-Lowry syndrome family revisited: Identification of two novel mutations of RPS6KA3 in three male patients.
• Familial 46,XY sex reversal without campomelic dysplasia caused by a deletion upstream of the SOX9 gene.
• Differential expression of nasal embryonic LHRH factor (NELF) variants in immortalized GnRH neuronal cell lines.
• miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance.
• Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant.
• Clinical genetic testing for kallmann syndrome.
• The genetic basis of female reproductive disorders: Etiology and clinical relevance.
• Identification of HESX1 mutations in Kallmann syndrome.
• Liquid Chromatography-Tandem Mass Spectrometry Analysis of Human Adrenal Vein 19-Carbon Steroids Before and After ACTH Stimulation.
• The Molecular Basis of Impaired Follicle-Stimulating Hormone Action: Evidence From Human Mutations and Mouse Models.
• Genetic considerations in the patient with Turner syndrome-45,X with or without mosaicism.
• Translocations Disrupting PHF21A in the Potocki-Shaffer-Syndrome Region Are Associated with Intellectual Disability and Craniofacial Anomalies.
• The prevalence of digenic mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.
• The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
• Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.
• Unique phenotype in a patient with CHARGE syndrome.
• Management of transverse vaginal septum using the Olbert balloon catheter to mobilize the proximal vaginal mucosa and facilitate low anastomosis.
• WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
• Retrieval of rhesus monkey (Macaca mulatta) oocytes by ultrasound-guided needle aspiration: problems and solutions.
• Phenotypic spectrum of 45,X/46,XY males with a ring Y chromosome and bilaterally descended testes.
• Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone beta subunit mu...
• Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
• Long-term follow-up and analysis of monozygotic twins concordant for 45,X/46,XY peripheral blood karyotype but discordant for phenotypic sex.
• Successful management of cervical pregnancy with medical intervention only: a case report.
• The genetics of hypogonadotropic hypogonadism.
• A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism.
• Editorial: BMP15--the first true ovarian determinant gene on the X-chromosome?
• Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism.
• The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism.
• Screening candidate genes for mutations in patients with hypogonadotropic hypogonadism using custom genome resequencing microarrays.
• Genetic causes of human infertility.
• Analysis of the Cys82Arg mutation in follicle-stimulating hormone beta (FSHbeta) using a novel FSH expression vector.
• Clinical phenotype and infertility treatment in a male with hypogonadotropic hypogonadism due to mutations Ala129Asp/Arg262Gln of the gonadotropin-releasing hormone re...
• FSH beta gene mutations in a female with partial breast development and a male sibling with normal puberty and azoospermia.
• Long-term follow-up of females with unbalanced X;Y translocations-reproductive and nonreproductive consequences.
• Interstitial microduplication at 2p11.2 in a patient with syndromic intellectual disability: 30-year follow-up.
• Sonographic evaluation of the adnexa during early pregnancy.
• Antenatal sonographic diagnosis of conjoined twins in a triplet pregnancy.
• A zona biochemical change and spontaneous cortical granule loss in eggs that fail to fertilize in in vitro fertilization.
• Biochemical study of individual zonae from human oocytes that failed to undergo fertilization in intracytoplasmic sperm injection.
• Human gene mutations causing infertility.
• The role of LH and FSH in ovarian androgen secretion and ovarian follicular development: clinical studies in a patient with isolated FSH deficiency and multicystic ova...
• Familial gonadotropin-releasing hormone resistance and hypogonadotropic hypogonadism in a family with multiple affected individuals.
• Mutations in the follicle-stimulating hormone-beta (FSH beta) and FSH receptor genes in mice and humans.
• Effect of follicle-stimulating hormone on ovarian androgen production in a woman with isolated follicle-stimulating hormone deficiency.
• Essential genetics for the obstetrician/gynecologist.
• Mutations of follicle stimulating hormone-beta and its receptor in human and mouse: genotype/phenotype.
• Genetics of human hypogonadotropic hypogonadism.
• Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay.
• Mutation analysis of the EMX2 gene in Kallmann's syndrome.
• The molecular basis of human hypogonadotropic hypogonadism.
• Molecular analysis of the gonadotropin-releasing hormone receptor in patients with polycystic ovary syndrome.
• Mutations in human gonadotropin genes and their physiologic significance in puberty and reproduction.
• Administration of progesterone before oocyte retrieval negatively affects the implantation rate.
• Use of denaturing gradient gel blots to screen for point mutations in the factor VIII gene.
• The Finnish follicle-stimulating hormone receptor gene mutation is rare in North American women with 46,XX ovarian failure.
• Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.
• Mutation analysis of the gonadotropin-releasing hormone receptor gene in idiopathic hypogonadotropic hypogonadism.
• Failed fertilization after intracytoplasmic sperm injection: the extent of paternal and maternal chromatin decondensation.
• Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene.
• Human chorionic gonadotrophin-beta gene sequences in women with disorders of HCG production.
• The detection of Hind III restriction-fragment length polymorphisms using a deoxyribonucleic acid probe for the beta subunit of follicle-stimulating hormone.
• Gonadotropin-releasing hormone, follicle-stimulating hormone beta, luteinizing hormone beta gene structure in idiopathic hypogonadotropic hypogonadism.
• Etiologic factors of recurrent abortion and subsequent reproductive performance of couples: have we made any progress in the past 10 years?
• Absence of the testicular determining factor gene SRY in XX true hermaphrodites and presence of this locus in most subjects with gonadal dysgenesis caused by Y aneuplo...
• Gonadotropin-releasing hormone-associated peptide gene sequences in women with hyperprolactinemia.
• Identification of restriction-fragment length polymorphisms for the human chorionic gonadotropin-beta/luteinizing hormone-beta gene cluster.
• Basic concepts of molecular biology as applied to pediatric and adolescent gynecology.
• Relevance of molecular medicine to clinical obstetrics and gynecology.
• Molecular biology in reproductive endocrinology.
• Dicavitary uteri with twin gestation: a case following clomiphene citrate therapy and review of obstetric outcomes.
• Follicle-stimulating hormone beta gene structure in premature ovarian failure.
• Ultrasound prediction of follicle volume: is the mean diameter reflective?
• The follicle-stimulating hormone receptor gene is polymorphic in premature ovarian failure and normal controls.
• Autoantibodies against the FSH receptor: association or causation?
• Analysis of the PROP1 gene in a large cohort of patients with idiopathic hypogonadotropic hypogonadism.
• KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans.
• The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
• Clinical manifestations of impaired GnRH neuron development and function.
• NELF is a nuclear protein involved in hypothalamic GnRH neuronal migration.
• Rarer syndromes characterized by hypogonadotropic hypogonadism.
• Genotype and phenotype of patients with gonadotropin-releasing hormone receptor mutations.
• Comparative deletion mapping at 1p31.3-p32.2 implies NFIA responsible for intellectual disability coupled with macrocephaly and the presence of several other genes for...

Schools

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• Univ Of Cincinnati Coll Of Med

• Jewish Hospital

• University Of Louisville Hospital

• Med Coll Of Ga

Procedures Preformed

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• Contraceptive Management
• Hysterosalpingography
• Hysteroscopy
• In Vitro Fertilization
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Doctors Specialties

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• Obstetrics
• Gynecology

Accepted Insurances

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Awards

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• Regional Top Doctor
• Fellow (FACOG)

Education

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• Medical College of Georgia
• University of Louisville
• University of Cincinnati College of Medicine

Hospital

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• Georgia Regents Medical Center

Drug Facts

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NPI NUMBER		1538278940
NPPES Provider LastName		LAYMAN
NPPES Provider FirstName		LAWRENCE
NPPES Provider ZIPCode		309045806
NPPES Provider State		GA
Specialty Description		Obstetrics/Gynecology
Total Claim Count		152.0
Distinct Opioid Count		0.0
Opioid Claim Count		0.0
Percent Opioid Claims		0.0

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1538278940
Last Name Of The Provider	LAYMAN
First Name Of The Provider	LAWRENCE
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