Physician
Internal Medicine
Dr. Lakshman Gunaratnam, MD
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Lakshman Gunaratnam works in the field of Internal Medicine. Lakshman Gunaratnam is a published physician. He published 20 publications, including: 'Localized mandibular enlargement in end-stage renal disease: two case reports and a review of the literature.'
Publications
- Localized mandibular enlargement in end-stage renal disease: two case reports and a review of the literature.
- Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes.
- T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice.
- Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encep...
- TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors.
- HIF in kidney disease and development.
- TGF-alpha as a candidate tumor antigen for renal cell carcinomas.
- Identification of PP2A as a novel interactor and regulator of TRIP-Br1.
- Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.
- Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer.
- Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.
- Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.
- Regulation of ubiquitin ligase dynamics by the nucleolus.
- Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
- Oxygen sensing by H+: implications for HIF and hypoxic cell memory.
- HIF activation by pH-dependent nucleolar sequestration of VHL.
- Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma ce...
- Increased myofibrillar protein phosphatase-1 activity impairs rat aortic smooth muscle activation after hypoxia.
Doctors Specialties
- Nephrology
- Internal Medicine
Accepted Insurances
Education
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University of Ottawa Faculty of Medicine
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