Physician
Neurology
Dr. Kenneth S. Kosik, MD
Dr. Kenneth S. Kosik practices Neurology. Dr. Kenneth S. Kosik is also published. He has 99 publications published. The lastest publication: "Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons.'
Publications
- Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease.
- Tau immunization: a cautionary tale?
- The Outer Subventricular Zone and Primate-Specific Cortical Complexification.
- Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.
- MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements.
- SMN regulates axonal local translation via miR-183/mTOR pathway.
- Synaptic dysregulation in a human iPS cell model of mental disorders.
- A quantitative framework to evaluate modeling of cortical development by neural stem cells.
- Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.
- Parallel discovery of Alzheimer's therapeutics.
- Frontispiece: particle display: a quantitative screening method for generating high-affinity aptamers.
- Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers.
- Novel Primate miRNAs Coevolved with Ancient Target Genes in Germinal Zone-Specific Expression Patterns.
- Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.
- Diaminothiazoles modify tau phosphorylation and improve the tauopathy in mouse models.
- Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.
- Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.
- MUC1* Ligand, NM23-H1, Is a Novel Growth Factor That Maintains Human Stem Cells in a More Naïve State.
- Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study.
- Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers.
- Functionalization of a protosynaptic gene expression network.
- Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.
- Deep annotation of mouse iso-miR and iso-moR variation.
- Identification of piRNAs in the central nervous system.
- NMDA Mediated Contextual Conditioning Changes miRNA Expression.
- MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.
- MicroRNA regulation of neural stem cells and neurogenesis.
- Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice.
- MicroRNAs and cellular phenotypy.
- Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology.
- A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation.
- MicroRNAs potentiate neural development.
- MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
- MicroRNA-124: micromanager of neurogenesis.
- The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
- Regulation of AMPA receptor trafficking by delta-catenin.
- A delta-catenin signaling pathway leading to dendritic protrusions.
- Noncoding RNAs in Long-Term Memory Formation.
- MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
- Heterogeneous dysregulation of microRNAs across the autism spectrum.
- MUC1* mediates the growth of human pluripotent stem cells.
- Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.
- A post-synaptic scaffold at the origin of the animal kingdom.
- Detection of a microRNA signal in an in vivo expression set of mRNAs.
- Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.
- Growth hormone is produced within the hippocampus where it responds to age, sex, and stress.
- Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
- Highly conserved O-fucose sites have distinct effects on Notch1 function.
- The Elegance of the MicroRNAs: A Neuronal Perspective.
- Teaching resources. A model for local regulation of translation near active synapses.
- MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
- Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
- Development of a fluorescent high throughput assay for tau aggregation.
- Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species.
- Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP.
- Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
- Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
- CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
- BACE1 suppression by RNA interference in primary cortical neurons.
- Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
- Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL.
- The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.
- Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.
- A microRNA array reveals extensive regulation of microRNAs during brain development.
- Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.
- Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.
- Discovery of compounds that will prevent tau pathology.
- RNAi functions in cultured mammalian neurons.
- Spatial learning and memory is preserved in rats after early development in a microgravity environment.
- Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
- The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.
- The message and the messenger: delivering RNA in neurons.
- Transcriptional profiling reveals regulated genes in the hippocampus during memory formation.
- The molecular and cellular biology of tau.
- Process formation in Sf9 cells induced by the expression of a microtubule-associated protein 2C-like construct.
- Intraneuronal compartments of the amyloid precursor protein.
- Morphometric image analysis of neuropil threads in Alzheimer's disease.
- Axotomy-induced neurofilament phosphorylation is inhibited in situ by microinjection of PKA and PKC inhibitors into identified lamprey neurons.
- Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.
- Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo.
- Cellular signaling pathways and cytoskeletal organization.
- A tau promoter region without neuronal specificity.
- Accelerated neuronal differentiation induced by p53 suppression.
- The pool of map kinase associated with microtubules is small but constitutively active.
- The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
- MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth.
- Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth.
- Translocation of RNA granules in living neurons.
- Postsynaptic element contributes to the delay in synaptogenesis in synapsin I-deficient neurons.
- Microtubule-associated protein 2c reorganizes both microtubules and microfilaments into distinct cytological structures in an actin-binding protein-280-deficient melan...
- Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.
- Presenilin 1 interaction in the brain with a novel member of the Armadillo family.
- Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.
- Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension.
- Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons.
- Pathologic changes in olfactory neurons in Alzheimer's disease.
- Evidence for the involvement of Tiam1 in axon formation.
- Alzheimer''s Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.
Schools
Med Coll Of Pa
Doctors Specialties
- Neurology
Accepted Insurances
Education
-
Tufts Medical Center
Helpful Reviews
Similar Doctors
|
Dr. Robert D. Harbaugh, MD
 This Doctor is OpenDoctor Recommended.
|
|
Dr. David G. Frecker, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Julia E. Bryson, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. John A. Zolan, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Paul Gertler, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Scott T. Grafton, MD |
|
|
Dr. William A. Rack, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Philip R. Delio, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Judith A. Willis, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Joel R. Morton, DO |
|
|
Dr. Sarah Kempe-Mehl, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Karen B. Dasilva, MD |
|
|
Dr. Richard M. Lowenthal, MD |