Professor, Medicine, UCSF School of Medicine
Endocrinology
Dr. Kenneth R. Feingold, MD
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Kenneth Feingold is an expert in the field of Endocrinology. He researched medicine at State University of New York Upstate Medical University. He over the years received 1 awards: "Elected Member". Kenneth Feingold is a published MD. He has 99 papers published. The most current publication "Inflammation Stimulates Niacin Receptor (GPR109A/HCA2) Expression in Adipose Tissue and Macrophages."
Publications
- Inflammation Stimulates Niacin Receptor (GPR109A/HCA2) Expression in Adipose Tissue and Macrophages.
- Paradoxical Benefits of Psychological Stress in Inflammatory Dermatoses Models are Glucocorticoid-Mediated.
- Functional Epidermal Permeability Barrier in Human Epidermal Equivalents.
- The adverse effect of IFN gamma on stratum corneum structure and function in psoriasis and atopic dermatitis.
- The important role of lipids in the epidermis and their role in the formation and maintenance of the cutaneous barrier.
- Role of lipids in the formation and maintenance of the cutaneous permeability barrier.
- Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis.
- Diabetes and Risk of Hospitalized Fall Injury Among Older Adults.
- Capsule Commentary on Radin, Pitfalls in Hemoglobin A1c Measurement: When Results May Be Misleading.
- Innate immunity stimulates permeability barrier homeostasis.
- Ceramides stimulate caspase-14 expression in human keratinocytes.
- Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
- Lipids: a key player in the battle between the host and microorganisms.
- Lamellar bodies: the key to cutaneous barrier function.
- Psoriasis: it's more than just the skin.
- Mechanisms of triglyceride accumulation in activated macrophages.
- FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
- Abnormal barrier function in the pathogenesis of ichthyosis: Therapeutic implications for lipid metabolic disorders.
- Regulation of permeability barrier homeostasis.
- Angiopoietin like protein 4 expression is decreased in activated macrophages.
- Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis.
- Inflammation inhibits GPR81 expression in adipose tissue.
- Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.
- PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis.
- The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes/epidermis.
- Lipid metabolism in the epidermis.
- The mechanisms by which lipids coordinately regulate the formation of the protein and lipid domains of the stratum corneum: Role of fatty acids, oxysterols, cholestero...
- Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue.
- Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
- The role of HDL in innate immunity.
- Regulation of ABCG1 expression in human keratinocytes and murine epidermis.
- Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.
- Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?
- Cardiolipin Synthase-1 mRNA Expression Does Not Correlate with Endogenous Cardiolipin Synthase Enzyme Activity In Vitro and In Vivo in Mammalian Lipopolysaccharide Mod...
- Does inhibition of apolipoprotein B synthesis produce foie gras?
- The acute phase response inhibits reverse cholesterol transport.
- PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation.
- Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.
- The acute phase response stimulates the expression of angiopoietin like protein 4.
- Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.
- Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm.
- Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
- Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes.
- pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.
- Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.
- The outer frontier: the importance of lipid metabolism in the skin.
- The "caveolae brake hypothesis" and the epidermal barrier.
- Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.
- Endotoxin in the gut and chylomicrons: translocation or transportation?
- LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes.
- LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney.
- Inflammation stimulates the expression of PCSK9.
- Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperpl...
- HDL and innate immunity: a tale of two apolipoproteins.
- Skin as an endocrine organ: implications for its function.
- Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers.
- Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.
- Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.
- PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
- Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versu...
- Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2.
- Stratum corneum acidification is impaired in moderately aged human and murine skin.
- Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis.
- Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice.
- The regulation of permeability barrier homeostasis.
- Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.
- Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
- Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function.
- Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins.
- Regulation of ABCA1 expression in human keratinocytes and murine epidermis.
- Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.
- Thiazolidinedione use and bone loss in older diabetic adults.
- Serine protease signaling of epidermal permeability barrier homeostasis.
- Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome.
- Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy.
- Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).
- Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis.
- FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity.
- Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secret...
- LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes.
- Differential expression of fatty acid transport proteins in epidermis and skin appendages.
- Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate.
- Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.
- Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.
- Suppression of estrogen-related receptor alpha and medium-chain acyl-coenzyme A dehydrogenase in the acute-phase response.
- Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and strat...
- Is endogenous glycerol a determinant of stratum corneum hydration in humans?
- Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists.
- Parotid secretory protein is an HDL-associated protein with anticandidal activity.
- Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity.
- Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.
- Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis.
- Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.
- Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
- Functional consequences of a neutral pH in neonatal rat stratum corneum.
- The effect of LXR activators on AP-1 proteins in keratinocytes.
- Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis).
- Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
Schools
Upstate Medical University College of Health Professions
University Wisc Hosps
Va Hospital University Calif
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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University of Wisconsin -
State University of New York Upstate Medical University
Hospital
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UCSF Medical Center -
San Francisco VA Medical Center
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