Physician
Pediatric Endocrinology
Dr. Kathryn Thrailkill, MD
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Dr. Kathryn Thrailkill is an expert in the field of Pediatric Endocrinology. She studied medicine at The Ohio State University College of Medicine. Kathryn Thrailkill is also a published MD. She has 59 paper published. The most recent paper is: Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases.
Publications
- Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice.
- Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes.
- A Multicomponent Motivational Intervention to Improve Adherence Among Adolescents With Poorly Controlled Type 1 Diabetes: A Pilot Study.
- The role of vitamin D in the metabolic homeostasis of diabetic bone.
- Chronic vomiting and abdominal pain in an adolescent male.
- Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.
- Dual hormonal replacement therapy with insulin and recombinant human insulin-like growth factor (IGF)-I in insulin-dependent diabetes mellitus: effects on the growth h...
- Dual hormonal replacement with insulin and recombinant human insulin-like growth factor I in IDDM. Effects on glycemic control, IGF-I levels, and safety profile.
- Relaxin stimulates the synthesis and release of prorenin from human decidual cells: evidence for autocrine/paracrine regulation.
- Decidual prolactin (PRL)-releasing factor stimulates the synthesis of PRL from human decidual cells.
- Improvement of HbA1c without increased hypoglycemia in adolescents and young adults with type 1 diabetes mellitus treated with recombinant human insulin-like growth fa...
- Dysregulation of the intrarenal vitamin D endocytic pathway in a nephropathy-prone mouse model of type 1 diabetes.
- Insulin pump therapy started at the time of diagnosis: effects on glycemic control and pancreatic ?-cell function in type 1 diabetes.
- GAD-alum immunotherapy in Type 1 diabetes mellitus.
- Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone.
- Palmitate and insulin synergistically induce IL-6 expression in human monocytes.
- Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus.
- Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in vitamin D deficiency?
- Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficien...
- Stimulant medication use and response to growth hormone therapy: an NCGS database analysis.
- Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF.
- Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin.
- Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy.
- Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus.
- Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial.
- Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
- A novel rat model for the study of deficits in bone formation in type-2 diabetes.
- Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model.
- Efficacy and safety of mecasermin rinfabate.
- Physiological matrix metalloproteinase (MMP) concentrations: comparison of serum and plasma specimens.
- Investigational agents for the treatment of growth hormone-insensitivity syndrome.
- Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology.
- Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.
- Bone formation is impaired in a model of type 1 diabetes.
- SomatoKine: is there a use in treating growth Disorders?
- Cyclic AMP as a second messenger for prorenin release from human decidual cells.
- Effect of bilateral adrenalectomy on blood sugar level and plasma refill in a rat hemorrhagic shock model.
- Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.
- Insulin-like growth factor-I in diabetes mellitus: its physiology, metabolic effects, and potential clinical utility.
- Effects of ibuprofen on a porcine model of acute respiratory failure.
- Insulin-like growth factor I stimulates the synthesis and release of prolactin from human decidual cells.
- The effects of co-therapy with recombinant human insulin-like growth factor I and insulin on serum leptin levels in adolescents with type 1 diabetes mellitus.
- Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type).
- Pediatric diabetes management in Appalachian Kentucky: adherence of primary care physicians to ADA guidelines.
- MMPs are IGFBP-degrading proteinases: implications for cell proliferation and tissue growth.
- Characterization of matrix metalloproteinases in human urine: alterations during adolescence.
- Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.
- Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases.
- Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP...
- Insulin stimulates the synthesis and release of prolactin from human decidual cells.
- Three distinct forms of insulin-like growth factor binding proteins are released by decidual cells in culture.
- Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases.
- Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs.
- Role of serum in the developmental expression of alkaline phosphatase in MC3T3-E1 osteoblasts.
- Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.
- Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.
- Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis.
- Intracellular population genetics: evidence for random drift of mitochondrial allele frequencies in Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Schools
Ohio State University College of Medicine
Duke University Med Center
Conditions Treated
- Adrenogenital Disorders
- Menstrual Disorders (incl. Dysmenorrhea)
Doctors Specialties
- Pediatric Endocrinology
Accepted Insurances
Education
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Duke University Hospital -
The Ohio State University College of Medicine
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