Associate Professor, Psychiatry, Baylor College of Medicine

Psychiatry

Doctor Karley Y. Little Jr., MD practices Psychiatry. He researched medicine at Medical College of Georgia School of Medicine. Karley Y. Little Jr., MD is also a published physician. He has 33 paper published. The most recent paper is: Striatal dopaminergic abnormalities in human cocaine users. He accepts Medicare payments and is registered with Medicare.gov.

Publications

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• Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users.
• Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with Alcoholism.
• Cocaine induction of dopamine transporter trafficking to the plasma membrane.
• Dose-response studies with thyrotropin-releasing hormone: evidence for differential pituitary responses in men with major depression, Alcoholism, or no psychopathology.
• Autoradiographic characterization of [3H]imipramine and [3H]citalopram binding in rat and human brain: species differences and relationships to serotonin innervation p...
• Predictors of response to high dose antipsychotics in chronic schizophrenics.
• Altered pineal serotonin binding in some suicides.
• Lithium potentiation of tricyclic antidepressants following lack of T3 potentiation.
• Dopamine receptor gene expression in the human medial temporal lobe.
• d-Amphetamine versus methylphenidate effects in depressed inpatients.
• Lack of pineal beta-adrenergic receptor alterations in suicide victims with Major depression.
• Beta-adrenergic receptor subtypes in human pineal gland.
• A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology ...
• Effects of cocaine on D3 and D4 receptor expression in the human striatum.
• Cocaine use increases [3H]WIN 35428 binding sites in human striatum.
• [125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain.
• Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration.
• Acute stimulant response prediction of chronic trazodone effects.
• Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain.
• Serotonin transporter binding sites and mRNA levels in depressed persons committing suicide.
• Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites.
• Overt behavior problems and serotonergic function in middle childhood among male and female offspring of Alcoholic fathers.
• Striatal [125I]RTI-55 binding sites in cocaine-abusing humans.
• Expression of serotonin transporter mRNA in human brainstem raphe nuclei.
• Characterization and localization of [125I]RTI-121 binding sites in human striatum and medial temporal lobe.
• Expression and regulation of the human dopamine transporter in a neuronal cell line.
• Alteration of brain dopamine and serotonin levels in cocaine users: a preliminary report.
• Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study.
• Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels.
• Striatal dopaminergic abnormalities in human cocaine users.
• Decreased brain dopamine cell numbers in human cocaine users.
• Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects.

Schools

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• Medical College of Georgia

• University Of Nc Hosps

Procedures Preformed

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• Psychiatric Evaluation

Conditions Treated

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• Alcoholism (Alcohol Dependence)
• Bipolar Disorder
• Drug and Alcohol Dependence
• Major Depressive Disorder
• View All

Doctors Specialties

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• Addiction Psychiatry
• Psychiatry

Accepted Insurances

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Education

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• University of North Carolina Hospitals
• Medical College of Georgia School of Medicine

Hospital

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• Michael E. DeBakey Veterans Affairs Medical Center

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