Associate Professor, Ophthalmology, Perelman School of Medicine
Ophthalmology
Dr. Joshua L. Dunaief, MD
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Dr. Joshua L. Dunaief is an expert in the field of Ophthalmology. He researched medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a one of the best medicals schools. Columbia University College of Physicians & Surgeons is ranked 8 in research and 52 in primary care medicine He received awards:"CMS Meaningful Use Stage 1 Certification" and "Fellow (FAAO)". Joshua Dunaief is a published doctor. He published 67 publications, including: 'Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins.'
Publications
- Berberine protects against light-induced photoreceptor Degeneration in the mouse retina.
- Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
- CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet.
- Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-Canonical TGF-β Signaling in the Retinal Pigment Epithelium.
- Iron increases APP translation and amyloid-beta production in the retina.
- A murine rp1 missense mutation causes protein mislocalization and slowly progressive photoreceptor Degeneration.
- Iron upregulates melanogenesis in cultured Retinal pigment epithelial cells.
- A High Serum Iron Level Causes Mouse Retinal Iron Accumulation Despite an Intact Blood-Retinal Barrier.
- The oral iron chelator deferiprone protects against systemic iron overload-induced retinal Degeneration in Hepcidin knockout mice.
- Dexras1, a Small GTPase, Is Required for Glutamate-NMDA Neurotoxicity.
- Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor Degeneration in the mouse retina.
- Microarray analysis of murine Retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.
- Ferroxidase Hephaestin's Cell-Autonomous Role in the Retinal Pigment Epithelium.
- DNA Methylation Is Associated with Altered Gene Expression in AMD.
- Aceruloplasminemia: Retinal histopathologic manifestations and iron-mediated melanosome degradation.
- A Significant Drug-Drug Interaction Detected Through Corneal Examination: Resolution of Cornea Verticillata While Using Amiodarone.
- Bmp6 regulates retinal iron homeostasis and has altered expression in age-related Macular degeneration.
- Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
- Ironing out neuroDegeneration: Iron chelation for neuroprotection.
- Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
- The oral iron chelator deferiprone protects against iron overload-induced retinal Degeneration.
- mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor Degeneration in mice.
- Age-dependent retinal iron accumulation and Degeneration in hepcidin knockout mice.
- Association of risk factors for choroidal neovascularization in age-related Macular degeneration with decreased foveolar choroidal circulation.
- Iron chelation protects the Retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli.
- Iron prochelator BSIH protects Retinal pigment epithelial cells against cell death induced by hydrogen peroxide.
- Oxidative stress in diseases of the human cornea.
- Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subRetinal hemorrhage.
- Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
- Foveolar choroidal circulation and choroidal neovascularization in age-related Macular degeneration.
- Iron toxicity as a potential factor in AMD.
- Iron induced oxidative damage as a potential factor in age-related Macular degeneration: the Cogan Lecture.
- Retinal localization and copper-dependent relocalization of the Wilson and Menkes disease proteins.
- The iron carrier transferrin is upregulated in retinas from patients with age-related Macular degeneration.
- Could blue light-blocking lenses decrease the risk of age-related Macular degeneration?
- Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related Macular degeneration.
- Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload.
- Persistent fetal ocular vasculature in mice deficient in bax and bak.
- Receptor for advanced glycation end products and age-related Macular degeneration.
- Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related Macular degeneration.
- Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.
- Mitochondria-derived reactive oxygen species mediate blue light-induced death of Retinal pigment epithelial cells.
- Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis.
- Maculas affected by age-related Macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane.
- Amyloid-beta is found in drusen from some age-related Macular degeneration retinas, but not in drusen from normal retinas.
- Increased expression of ceruloplasmin in the retina following photic injury.
- The role of apoptosis in age-related Macular degeneration.
- The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice.
- Retinal iron homeostasis in health and disease.
- Retinal venous telangiectasia and anastomoses with cerebellar venous and cavernous malformation.
- Corneal dystrophies of epithelial genesis: the possible therapeutic use of limbal stem cell transplantation.
- Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins.
- Retroviral gene transfer into Retinal pigment epithelial cells followed by transplantation into rat retina.
- The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.
- Deficiency of Bax and Bak protects photoreceptors from light damage in vivo.
- Adenovirus-mediated delivery of catalase to Retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress.
- Increased metallothionein in light damaged mouse retinas.
- Light damage induced changes in mouse Retinal gene expression.
- Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo.
- Iron homeostasis and toxicity in retinal Degeneration.
- Isoprostane F2alpha-VI, a new marker of oxidative stress, increases following light damage to the mouse retina.
- Iron levels in human retina: sex difference and increase with age.
- Iron homeostasis and eye disease.
- DICER1 deficit induces Alu RNA toxicity in age-related Macular degeneration.
- Brain and Retinal ferroportin 1 dysregulation in polycythaemia mice.
- Age-dependent and gender-specific changes in mouse tissue iron by strain.
Schools
Columbia University College Of Physicians and Surgeons
Johns Hopkins University School Med
University Of MD Med Sys
Conditions Treated
- Age-Related Macular Degeneration
- Anterior Scleritis
- Benign Neoplasm of Choroid
- Benign Neoplasm of Eye
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Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FAAO)
Education
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Johns Hopkins University -
University of Maryland -
Columbia University College of Physicians & Surgeons
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
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