Samuel A. Levine Professor of Medicine, Brigham and Women's Hospital
Nephrology
Dr. Joseph V. Bonventre, MD
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Joseph V. Bonventre practices Nephrology. He went to medical school at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He received awards:"Elected Member", "Fellow (ASNF)" and "Super Doctor". Joseph Bonventre is a published doctor as well. He has 102 publications published. The latest was: Acute kidney injury and chronic kidney disease: From the laboratory to the clinic.
Publications
- Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery.
- Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2.
- Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model.
- Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients.
- Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study.
- Increased plasma kidney injury molecule-1 suggests early progressive renal decline in non-proteinuric patients with type 1 diabetes.
- Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.
- Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury.
- Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium.
- Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells.
- Regenerating the nephron with human pluripotent stem cells.
- Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.
- RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm.
- Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.
- Stigmata of death: for kidneys and patients.
- Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury.
- Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
- The Kidney Disease Screening and Awareness Program (KDSAP): A Novel Translatable Model for Increasing Interest in Nephrology Careers.
- Urine kidney injury molecule-1: a potential non-invasive biomarker for patients with renal cell carcinoma.
- Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.
- Reduced Ciliary Polycystin-2 in Induced Pluripotent Stem Cells from Polycystic Kidney Disease Patients with PKD1 Mutations.
- Imperfect gold standards for biomarker evaluation.
- Multipotent mesenchymal stromal cells protect against kidney injury.
- Flow is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells.
- Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury.
- Meaningful measurement: developing a measurement system to improve blood pressure control in patients with chronic kidney disease.
- Novel assays for detection of urinary Kim-1 in mouse models of kidney injury.
- Kim-1/Tim-1 and immune cells: shifting sands.
- Use of Postoperative Creatinine to Predict Sustained Kidney Injury in Patients Undergoing Mesothelioma Surgery.
- Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis.
- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.
- Test Characteristics of Urinary Biomarkers Depend on Quantitation Method in Acute Kidney Injury.
- Cellular pathophysiology of ischemic acute kidney injury.
- Imperfect Gold Standards for Kidney Injury Biomarker Evaluation.
- Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion.
- Purification and characterization of a cytosolic Ca(2+)-independent phospholipase A (2) from bovine brain.
- Cytosolic phospholipase A(2)? protects against ischemia/reperfusion injury in the heart.
- Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation.
- Repair of injured proximal tubule does not involve specialized progenitors.
- Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases.
- Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function.
- Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity.
- Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-gluc...
- The Sweet Pee model for Sglt2 mutation.
- Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury.
- The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair.
- TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity.
- Kidney injury molecule-1.
- Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.
- Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate.
- Performance of novel kidney biomarkers in preclinical toxicity studies.
- Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
- Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies.
- Next-generation biomarkers for detecting kidney toxicity.
- Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.
- Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.
- Impact of Cyclin B2 and Cell division cycle 2 on tubular hyperplasia in progressive chronic renal failure rats.
- Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1.
- Tubular expression of KIM-1 does not predict delayed function after transplantation.
- Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.
- Ceramide 1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis.
- HIF in kidney disease and development.
- Preclinical evaluation of novel urinary biomarkers of cadmium nephrotoxicity.
- Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury.
- A rapid urine test for early detection of kidney injury.
- Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.
- Microvesicles from mesenchymal stromal cells protect against acute kidney injury.
- Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time.
- Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney.
- Creatinine kinetics and the definition of acute kidney injury.
- Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic pr...
- Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyr...
- Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans.
- Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge.
- Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
- Renoprotective mechanisms of soy protein intake in the obese Zucker rat.
- Dialysis in acute kidney injury--more is not better.
- A framework and key research questions in AKI diagnosis and staging in different environments.
- Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.
- Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi.
- Intrinsic epithelial cells repair the kidney after injury.
- Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.
- Biomarkers of acute kidney injury.
- Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
- Mesenchymal stem cells in acute kidney injury.
- Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
- High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients.
- Rapid screening of glomerular slit diaphragm integrity in larval zebrafish.
- Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region.
- Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice.
- The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity.
- Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2alpha activation.
- Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts.
- Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma.
- Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure.
- NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure.
- Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase.
- Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity.
- A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9.
- M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.
- Acute kidney injury and chronic kidney disease: From the laboratory to the clinic.
Schools
Harvard Medical School
Massachusetts General Hospital
Mass Genl Hospital Harvard Med School
Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Elected Member
- Fellow (ASNF)
- Super Doctor
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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Brigham and Women's Hospital
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