Dean, Joan C Edwards School of Medicine Marshall University
Nephrology
Dr. Joseph I. Shapiro, MD
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Joseph I. Shapiro, MD practices Nephrology. He graduated from Rutgers New Jersey Medical School. Rutgers New Jersey Medical School is ranked 76/0 in Research/PrimaryCare. He has 9 awards "Regional Top Doctor", "Arnold P. Gold Humanism in Medicine", "Hypertension Fellow (FAHA)", "Kidney Disease Fellow (FAHA)", "Member", "Established Investigator Award", "Clinician Scientist Award", "NRSA" and "Fellow (ASNF)". Doctor Joseph I. Shapiro, MD is a published doctor. He has 99 publications published. The most current publication "Acute and chronic hypokalemia sensitize the isolated heart to hypoxic injury."
Publications
- Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors?
- Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice.
- Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia.
- Roll-in Experience from the Cardiovascular Outcomes With Renal Atherosclerotic Lesions (CORAL) Study.
- Stenting and medical therapy for atherosclerotic Renal-artery stenosis.
- Cardiotonic Steroids in Adaptation to Dietary Salt Intake.
- Involvement of Reactive Oxygen Species in a Feed-forward Mechanism of Na/K-ATPase-mediated Signaling Transduction.
- Passive Immunization Against Marinobufagenin Attenuates Renal Fibrosis and Improves Renal Function in Experimental Renal Disease.
- Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21.
- Effect of CD40 and sCD40L on renal function and survival in patients With renal artery stenosis.
- Principles of management of severe hyponatremia.
- Facing ubiquitous viruses: when hand washing is not enough.
- CD36 and Na/K-ATPase-?1 form a proinflammatory signaling loop in Kidney.
- Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal Failure.
- Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.
- Determinants of renal function in patients With renal artery stenosis.
- Platelet Activation in Patients With Atherosclerotic Renal Artery Stenosis Undergoing Stent Revascularization.
- Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells.
- Impairment of Na/K-ATPase signaling in Renal proximal tubule contributes to Dahl salt-sensitive hypertension.
- Endogenous cardiotonic steroids in chronic renal Failure.
- Signaling through the Na/K-ATPase: implications for cardiac fibrosis.
- Renal ischemia regulates marinobufagenin release in humans.
- Predictors of embolization during protected Renal artery angioplasty and stenting: Role of antiplatelet therapy.
- Identification of hydroxyxanthones as Na/K-ATPase ligands.
- Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin.
- "Pseudo-sickle" cell anemia.
- NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells.
- Complete versus partial distal embolic protection during Renal artery stenting.
- Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy.
- The cardiotonic steroid hormone marinobufagenin induces Renal fibrosis: implication of epithelial-to-mesenchymal transition.
- Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets.
- Effects of cardiotonic steroids on dermal collagen synthesis and wound healing.
- Embolic protection and platelet inhibition during Renal artery stenting.
- Partial nephrectomy as a model for uremic cardiomyopathy in the mouse.
- Regulation of apical NHE3 trafficking by ouabain-induced activation of the basolateral Na+-K+-ATPase receptor complex.
- Hyponatremia: clinical diagnosis and management.
- Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy.
- Ouabain decreases sarco(endo)plasmic reticulum Calcium ATPase activity in rat hearts by a process involving protein oxidation.
- Quality of life improves after Renal artery stenting.
- Erythropoietin resistance in the treatment of the anemia of chronic renal Failure.
- Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells.
- Non-contrast-enhanced computerized tomography and analgesic-related Kidney disease: report of the national analgesic nephropathy study.
- Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.
- Potassium depletion and cardiac hypertrophy: how does it work?
- Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells.
- Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1.
- Uremic cardiomyopathy: role of circulating digitalis like substances.
- Mechanisms for aldosterone and spironolactone-induced positive inotropic actions in the rat Heart.
- Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism.
- Renal insufficiency as a predictor of adverse events and mortality after Renal artery stent placement.
- Endocytosis and signal transduction: basic science update.
- Arthur Guyton, sodium, and Hypertension.
- Compliance With antihypertensive therapy after renal artery stenting.
- Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat.
- Effect of chronic renal Failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat.
- Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells.
- Rapid effects of aldosterone and spironolactone in the isolated working rat Heart.
- Effects of reduction of Renal mass on Renal oxygen tension and erythropoietin production in the rat.
- In preeclampsia endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteries.
- Endogenous cardiotonic steroids and salt-sensitive Hypertension.
- Neural network analysis to predict mortality in end-stage renal Disease: application to United States Renal Data System.
- Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia.
- Endogenous digitalis: pathophysiologic roles and therapeutic applications.
- Use of multiple fluorophores for evaluating microvascular permeability in control rats and rats With sepsis.
- Regulation of sodium pump endocytosis by cardiotonic steroids: Molecular mechanisms and physiological implications.
- Impact of preadmission variables on USMLE step 1 and step 2 performance.
- Plasma expansion by polyethylene-glycol-modified albumin.
- Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial...
- Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes.
- Ouabain interaction With cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations.
- Molecular insights into uremic cardiomyopathy: cardiotonic steroids and Na/K ATPase signaling.
- Identification of a pool of non-pumping Na/K-ATPase.
- Hypokalemia potentiates ouabain's effect on Calcium cycling and cardiac growth.
- Ischemic preconditioning attenuates functional, metabolic, and morphologic injury from ischemic Acute renal failure in the rat.
- Factors maintaining a pH gradient within the Kidney: role of the vasculature architecture.
- Effects of uremic serum on isolated cardiac myocyte Calcium cycling and contractile function.
- A potential role for immune activation in hemodialysis hypotension.
- Effects of enhanced oxygen release from hemoglobin by RSR13 in an Acute renal failure model.
- Cardiac performance in inbred rat genetic models of low and high running capacity.
- Investigating the effect of genetic background on proteinuria and Renal injury using two hypertensive strains.
- Time course of response to pulse methylprednisolone therapy in renal transplant recipients with Acute allograft rejection.
- Effects of hypokalemia on cardiac growth.
- Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
- Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome.
- Nuclear magnetic resonance and biochemical studies to determine the synergistic detrimental effects of Renal ischemia on cyclosporine nephrotoxicity in the rat.
- Acidosis and hypoxic medullary injury in the isolated perfused kidney.
- Effects of acetate on energy Metabolism and function in the isolated perfused rat heart.
- Tubular hypermetabolism as a factor in the progression of chronic renal Failure.
- Hypoxia and metabolic Acidosis in the isolated heart: evidence for synergistic injury.
- Acute and chronic hypokalemia sensitize the isolated heart to hypoxic injury.
- Nuclear magnetic resonance spectroscopy in patients with anion-gap Acidosis.
- Contractile dysfunction during metabolic Acidosis: role of impaired energy metabolism.
- Study of brain electrolytes and organic osmolytes during correction of Chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis.
- Loss of epithelial polarity: a novel hypothesis for reduced proximal tubule Na+ transport following ischemic injury.
- Effect of long-acting Calcium entry blocker (anipamil) on blood pressure, renal function and survival of uremic rats.
- Effects of hypernatremia on organic brain osmoles.
- Reduction of remnant nephron hyperMetabolism by protein restriction.
- Comparison of the natriuretic response to atriopeptin III and loop diuretic in the isolated perfused rat Kidney.
Schools
UmdnjNew Jersey Medical School
Georgetown University Hospital
University Of Colorado
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Calcium Metabolism Disorders
- Chronic Glomerulonephritis
- View All
Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Regional Top Doctor
- Arnold P. Gold Humanism in Medicine
- Hypertension Fellow (FAHA)
- Kidney Disease Fellow (FAHA)
- Member
- Established Investigator Award
- Clinician Scientist Award
- NRSA
- Fellow (ASNF)
Education
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Georgetown University Hospital -
Rutgers New Jersey Medical School -
University of Pennsylvania
Hospital
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Mercy St. Vincent Medical Center
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