Professor of Medicine, Massachusetts General Hospital

Endocrinology

Joseph Avruch practices Endocrinology. He went to Washington University School of Medicine in St. Louis. He received 2 awards: "Elected Member" and "Investigator Alumnus". Joseph Avruch, MD is a published doctor and has 56 publications published. The lastest was: 'Stress-activated protein kinases in cardiovascular disease.'

Publications

---

• Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
• YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
• Amino acids activate mTOR complex1 Without changing Rag GTPase guanyl nucleotide charging.
• G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylat...
• Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas.
• Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes.
• Protein kinases of the Hippo pathway: Regulation and substrates.
• The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.
• A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation.
• Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.
• Stress-activated protein kinases in cardiovascular disease.
• A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation.
• Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
• The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
• Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
• mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.
• Yap1 acts downstream of ?-catenin to control epidermal proliferation.
• Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.
• pTOM, a vector for expressing two proteins in mammalian cells.
• Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
• Rassf family of tumor suppressor polypeptides.
• The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
• The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
• The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.
• Characterization of two Mst1-deficient mouse models.
• Amino acid regulation of TOR complex 1.
• A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
• MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
• The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
• The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.
• MAP kinase pathways: the first twenty years.
• Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.
• Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
• Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.
• Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.
• Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.
• Rheb binds and regulates the mTOR kinase.
• Recent advances in the regulation of the TOR pathway by insulin and nutrients.
• Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.
• The scaffold protein CNK1 interacts With the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
• Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.
• Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases.
• Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.
• A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
• The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
• Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.
• TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.
• Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
• Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.
• RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.
• Identification of a novel Ras-regulated proapoptotic pathway.
• The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes With the Ras-GTP binding protein Nore1.
• Characterization of ubiquilin 1, an mTOR-interacting protein.
• 14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.

Schools

---

• Washington Center School of Medicine

• Barnes Jewish Hospital

• Mass General Hospital Boston

Conditions Treated

---

• Diabetes Type 1
• Diabetes Type 2
• Diabetes With Renal Manifestations
• Goiter
• View All

Doctors Specialties

---

• Endocrinology

Accepted Insurances

---

Awards

---

• Elected Member
• Investigator Alumnus

Education

---

• Massachusetts General Hospital
• Washington University - Barnes-Jewish Hospital
• Washington University School of Medicine in St. Louis

Hospital

---

• Massachusetts General Hospital

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Donald C. Simonson, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Emma B. Morton-Eggleston, MD
	Dr. Merav Baz-Hecht, MD
	Dr. Heather A. Ferris, MD This Doctor is OpenDoctor Recommended.
	Dr. Marie B. Demay, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Benjamin Z. Leder, MD This Doctor is OpenDoctor Recommended.
	Dr. Angela M. Leung, MD This Doctor is OpenDoctor Recommended.

---

Doctor Directory | TOS | twitter | FB | Angel | blog