Physician

Pediatrics

Jonathan D. Powell, MD practices Pediatrics. He attended Rush Medical College. He received 1 awards: "CMS Meaningful Use Stage 1 Certification". Jonathan Powell is also published. He has 60 publications published. The lastest publication: "Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy.'

Publications

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• Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model.
• Regulation of immune activation/retroviral replication by CD8+ T cells.
• Identification of SIV/SMM viral proteins that induce T cell response in experimentally infected rhesus macaques and naturally infected sooty mangabeys by the cellular ...
• Evidence for simian immunodeficiency virus-specific IgM and IgG response in peripheral blood mononuclear cells of serum enzyme-linked immunosorbent assay-negative nonh...
• Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates.
• An anchored restriction-mapping approach applied to the genetic analysis of the Anopheles gambiae malaria vector complex 1.
• Comparison of SIV/SMM replication in CD4+ T cell and monocyte/macrophage cultures from rhesus macaques and sooty mangabeys.
• Adenosine receptors and cancer.
• Requirements for simian immunodeficiency virus antigen-specific in vitro proliferation of T cells from infected rhesus macaques and sooty mangabeys.
• Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen.
• Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma.
• Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys.
• Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy.
• The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy.
• Distinct requirements for C-C chemokine and IL-2 production by naive, previously activated, and anergic T cells.
• Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.
• TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1).
• Anergic T cells are metabolically anergic.
• Pulmonary vaccination as a novel treatment for lung fibrosis.
• Fueling memories.
• Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes.
• Targeted immunosuppression: no longer naïve.
• Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.
• PI3K/mTOR signaling regulates prostatic branching morphogenesis.
• A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.
• The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
• Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.
• The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.
• Quieting T cells with Slfn2.
• High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease.
• Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy.
• The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
• Allogeneic hematopoietic stem-cell transplantation for sickle cell disease.
• Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome.
• Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation.
• mTOR: taking cues from the immune microenvironment.
• Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation.
• The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
• Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression.
• The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.
• HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide.
• Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.
• A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.
• Adenosine and anergy.
• A role for mammalian target of rapamycin in regulating T cell activation versus anergy.
• Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse.
• Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.
• Dissecting the mechanism of T-cell anergy with immunophilin ligands.
• Hyaluronan fragments act as an endogenous danger signal by engaging TLR2.
• Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells.
• The induction and maintenance of T cell anergy.
• Low-dose radiation plus rapamycin promotes long-term bone marrow chimerism.
• Threat matrix: low-molecular-Weight hyaluronan (HA) as a danger signal.
• Egr-2 and Egr-3 are negative regulators of T cell activation.
• Role of LAG-3 in regulatory T cells.
• Identification of the molecular mechanism by which TLR ligation and IFN-gamma synergize to induce MIG.
• The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction.
• Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.
• NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) exp...

Schools

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• Rush Medical College Of Rush University

• Advocate Lutheran General Hospital

Procedures Preformed

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• Immunization
• Newborn Care
• Physical Examination
• Vaccination
• View All

Conditions Treated

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• Allergies
• Weight Loss

Doctors Specialties

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• Pediatrics

Accepted Insurances

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Awards

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• CMS Meaningful Use Stage 1 Certification

Education

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• Advocate Lutheran General Hospital
• Rush Medical College

Hospital

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• Presence Resurrection Medical Center

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