Physician
Pathology
Dr. Jon L. Keller, MD
Keller is an expert in the field of Pathology. He studied medicine at University of Michigan Medical School. Keller is also published. He has 101 publications published. The lastest publication: "D3: a gene induced during myeloid cell differentiation of Linlo c-Kit+ Sca-1(+) progenitor cells.'
Publications
- Contrasting mechanisms of the myeloprotective effects of interleukin-1 against ionizing radiation and cytotoxic 5-fluorouracil.
- Transforming growth factor beta and interleukin-1: a paradigm for opposing regulation of haemopoiesis.
- Transcriptome analysis of mouse stem cells and early embryos.
- Transforming growth factor-beta: a bidirectional regulator of hematopoietic cell growth.
- Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.
- Prevention of acute chemotherapy-induced death in mice by recombinant human interleukin 1: protection from hematological and nonhematological toxicities.
- Growth inhibition of a human lymphoma cell line: induction of a transforming growth factor-beta-mediated autocrine negative loop by phorbol myristate acetate.
- Effects of growth hormone and prolactin on hematopoiesis.
- Epstein-Barr virus transformed B lymphocytes produce interleukin-5.
- Transforming growth factor beta inhibits the action of stem cell factor on mouse and human hematopoietic progenitors.
- Interleukins 2 and 3 regulate the in vitro proliferation of two distinguishable populations of 20-alpha-hydroxysteroid dehydrogenase-positive cells.
- Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.
- Retroviral v-myc infection of primary fetal liver cells: transformation of monocytes in vitro.
- Transforming growth factor beta: possible roles in the regulation of normal and leukemic hematopoietic cell growth.
- Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action.
- In vivo and in vitro effects of TGF-beta 1 on normal and neoplastic haemopoiesis.
- Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.
- Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice.
- Role of transforming growth factor-beta 1 in regulation of hematopoiesis.
- Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells.
- Role of fibroblast growth factors and their receptors in mouse primordial germ cell growth.
- Direct synergistic effects of IL-4 and IL-11 on proliferation of primitive hematopoietic progenitor cells.
- Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors.
- Increased granulopoiesis after sequential administration of transforming growth factor-beta 1 and granulocyte-macrophage colony-stimulating factor.
- Severe congenital neutropenia: abnormal growth and differentiation of myeloid progenitors to granulocyte colony-stimulating factor (G-CSF) but normal response to G-CSF...
- Transforming growth factor-beta 1 enhances the suppression of human hematopoiesis by tumor necrosis factor-alpha or recombinant interferon-alpha.
- TGF-beta is a bidirectional modulator of cytokine receptor expression on murine bone marrow cells. Differential effects of TGF-beta 1 and TGF-beta 3.
- Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.
- Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation.
- Administration of recombinant human interleukin-7 to mice induces the exportation of myeloid progenitor cells from the bone marrow to peripheral sites.
- Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-beta 1.
- Bidirectional effects of transforming growth factor beta (TGF-beta) on colony-stimulating factor-induced human myelopoiesis in vitro: differential effects of distinct ...
- Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro.
- Two forms of transforming growth factor-beta are equally potent selective growth inhibitors of early murine hematopoiesis.
- Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation.
- Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.
- Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells...
- Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
- Detection of growth factor receptor RNA in individual hematopoietic cells by in situ RT-PCR; comparison with RT-PCR.
- Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.
- Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens.
- In vivo effect of interleukin-1 alpha on hematopoiesis: role of colony-stimulating factor receptor modulation.
- The growth response of Lin-Thy-1+ hematopoietic progenitors to cytokines is determined by the balance between synergy of multiple stimulators and negative cooperation ...
- Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.
- Stem cell factor, the JAK-STAT pathway and signal transduction.
- Unique pathway of IL-3-driven hemopoietic differentiation.
- Quantitative and cell-cycle differences in progenitor cells mobilized by recombinant human interleukin-7 and recombinant human granulocyte colony-stimulating factor.
- Hematopoietic growth factors upregulate the p65 type II interleukin-1 receptor on bone marrow progenitor cells in vitro.
- In vivo interleukin-1 (IL-1) administration indirectly promotes type II IL-1 receptor expression on hematopoietic bone marrow cells: novel mechanism for the hematopoie...
- Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.
- Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo.
- Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells.
- Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines.
- Stem cell factor induces phosphorylation of a 200 kDa protein which associates with c-kit.
- The effect of c-raf antisense oligonucleotides on growth factor-induced proliferation of hematopoietic cells.
- Functional characterization of a novel hematopoietic stem cell and its place in the c-Kit maturation pathway in bone marrow cell development.
- Targeted gene transfer to human hematopoietic progenitor cell lines through the c-kit receptor.
- Introduction of v-abl oncogene induces monocytic differentiation of an IL-3-dependent myeloid progenitor cell line.
- Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.
- Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo.
- Engraftment of SCID mice by human bone marrow hematopoietic cells cultured in vitro: an in vivo model for human gene transfer.
- Distinct and direct synergistic effects of IL-1 and IL-6 on proliferation and differentiation of primitive murine hematopoietic progenitor cells in vitro.
- C/EBPepsilon is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes.
- Raf-1 protein is required for growth factor-induced proliferation of primitive hematopoietic progenitors stimulated with synergistic combinations of cytokines.
- JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor.
- Direct synergistic effects of leukemia inhibitory factor on hematopoietic progenitor cell growth: comparison with other hematopoietins that use the gp130 receptor subu...
- Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo model for genetically transferred chemoprotection.
- D3: a gene induced during myeloid cell differentiation of Linlo c-Kit+ Sca-1(+) progenitor cells.
- Engraftment of ex vivo expanded and cycling human cord blood hematopoietic progenitor cells in SCID mice.
- JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
- Interleukin-1 (IL-1) directly and indirectly promotes hematopoietic cell growth through type I IL-1 receptor.
- Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth.
- Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division.
- Induction of colony-stimulating factor receptor expression on hematopoietic progenitor cells: proposed mechanism for growth factor synergism.
- C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo.
- The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation.
- Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance,...
- RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
- Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development.
- Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche.
- The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.
- Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins.
- DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.
- The role of p202 in regulating hematopoietic cell proliferation and differentiation.
- Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene.
- IL-7 induces myelopoiesis and erythropoiesis.
- Role of the intracellular domain of IL-7 receptor in T cell development.
- Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions.
- Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
- C/EBPalpha determines hematopoietic cell fate in multipotential progenitor cells by inhibiting erythroid differentiation and inducing myeloid differentiation.
- p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.
- Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-def...
- IL-3 induces inhibitor of DNA-binding protein-1 in hemopoietic progenitor cells and promotes myeloid cell development.
- Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation.
- Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members.
- Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival.
- JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor.
- Identification of in vitro growth conditions for c-Kit-negative hematopoietic stem cells.
- Bcl11a is essential for normal lymphoid development.
- In vivo retroviral gene transfer by direct intrafemoral injection results in correction of the SCID phenotype in Jak3 knock-out animals.
Schools
University of Mi Med Sch
Med Center Hospital Of Vermont
Doctors Specialties
- Pathology
Accepted Insurances
Education
-
University of Vermont - Fletcher Allen Health Care -
University of Michigan Medical School
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1235225558 |
| Last Name Of The Provider | KELLER |
| First Name Of The Provider | JON |
| View All |
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