Professor, Medicine, University of Louisville School of Medicine
Nephrology
Dr. Jon Klein, MD
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Klein is an expert in the field of Nephrology. He attended University of Kansas School of Medicine. Jon Klein, MD is also a published physician. He has 100 publication published. The most recent publication is: Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice. Klein accepts Medicare.
Publications
- Proteomics and autoimmune Kidney disease.
- Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy.
- Differential expression of endoplasmic reticulum stress-response proteins in different Renal tubule subtypes of OVE26 diabetic mice.
- Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABABR-mediated chemotaxis.
- Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus.
- Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium.
- Quantitative Expression Proteomics and Phosphoproteomics Profile of Brain from PINK1 Knockout Mice: Insights into Mechanisms of Familial Parkinson Disease.
- Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy.
- Redox Proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy Metabolism after Doxorubicin treatment.
- Technical note: proteomic approaches to fundamental questions about neutrophil biology.
- ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.
- Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer Disease.
- Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implication...
- Calorimetric analysis of the plasma proteome: Identification of type 1 diabetes patients with early Renal function decline.
- Plasma kininogen and kininogen fragments are biomarkers of progressive Renal decline in type 1 diabetes.
- Days* - A bright future on solid foundations.
- Elongin C is a mediator of Notch4 activity in human Renal tubule cells.
- Role of vacuolar ATPase in the trafficking of Renal type IIa sodium-phosphate cotransporter.
- Oncostatin M receptor beta and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients.
- Ich denk' es war ein gutes Jahr* (Reinhard Mey, 1968)--the year 2010 balance.
- Microfiltration isolation of human urinary exosomes for characterization by MS.
- Proteomics in CKD.
- Proteomic discovery of diabetic nephropathy biomarkers.
- Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome.
- Recommendations for biomarker identification and qualification in clinical proteomics.
- Quantitative mass spectrometry of diabetic Kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.
- It's the end of the world as we know it* - an era comes to a close.
- Interplay between Akt and p38 MAPK pathways in the regulation of Renal tubular cell apoptosis associated with diabetic nephropathy.
- Urinary peptidome may predict Renal function decline in type 1 diabetes and microalbuminuria.
- M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
- Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes.
- Proteomics and diabetic retinopathy.
- Splice variants of neuronal nitric oxide synthase are present in the rat Kidney.
- Synthesis and secretion of hemoglobin by retinal pigment epithelium.
- Regulation of neutrophil apoptosis by modulation of PKB/Akt activation.
- Renal tubulointerstitial fibrosis in OVE26 type 1 diabetic mice.
- Proteomic analysis of renal calculi indicates an important role for inflammatory processes in Calcium stone formation.
- Proteomic techniques identify urine proteins that differentiate patients with interstitial cystitis from asymptomatic control subjects.
- Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in th...
- Proteomics and diabetic nephropathy.
- Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment:...
- Utlization of human expert techniques for detection of low-abundant peaks in high-resolution mass spectra.
- Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product Metabolism in glomeruli of db/db diabetic mice.
- Proteomics analysis of the Alzheimer's Disease hippocampal proteome.
- Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury.
- Proteomic identification and immunolocalization of increased Renal calbindin-D28k expression in OVE26 diabetic mice.
- An increase in S-glutathionylated proteins in the Alzheimer's Disease inferior parietal lobule, a proteomics approach.
- Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization.
- Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's Disease: an initial assessment.
- Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice.
- Redox proteomics identification of oxidized proteins in Alzheimer's Disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterati...
- Protective effect of D609 against amyloid-beta1-42-induced oxidative modification of neuronal proteins: redox proteomics study.
- AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.
- Proteomic analysis of human neutrophils.
- Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's Disease.
- A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
- Oxidative modification and down-regulation of Pin1 in Alzheimer's Disease hippocampus: A redox proteomics analysis.
- Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular proces...
- Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's Disease.
- Urinary protein expression patterns in children with sleep-disordered breathing: preliminary findings.
- Identification of nitrated proteins in Alzheimer's Disease brain using a redox proteomics approach.
- Effects of ACE inhibition on proximal tubule sodium transport.
- Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington Disease.
- Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity.
- Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins.
- Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abet...
- Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
- Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion.
- Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: implications for Alzheimer's Disease.
- Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
- Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach.
- Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat.
- Proteomics analysis of human astrocytes expressing the HIV protein Tat.
- Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative Disorders.
- Cardiac mitochondrial damage and biogenesis in a Chronic model of type 1 diabetes.
- Alterations in the Renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis.
- Analysis of expression and posttranslational modification of proteins during hypoxia.
- Practical bioinformatics for proteomics.
- Urinary proteomics and biomarker discovery for glomerular Diseases.
- Overview of proteomics.
- Sample preparation for 2-D proteomic analysis.
- Two-dimensional gel electrophoresis: a fundamental tool for expression proteomics studies.
- Proteomics and diabetic nephropathy.
- Proteomics and Hypertension.
- Proteomic identification of a large complement of rat urinary proteins.
- Prediction of delayed Renal allograft function using an artificial neural network.
- Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
- Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in R...
- Heat shock protein 27 controls apoptosis by regulating Akt activation.
- Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
- Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia.
- Proteomic identification of nitrated proteins in Alzheimer's Disease brain.
- Sodium loading changes urinary protein excretion: a proteomic analysis.
- Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils.
- Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein.
- Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia.
- Proteomic identification of oxidatively modified proteins in Alzheimer's Disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock c...
- Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation.
- Differential expression of proteins in Renal cortex and medulla: a proteomic approach.
Schools
University Of Texas Medical Branch At Galveston
University Of Kansas Medical Center
University Of Louisville Hospital
Procedures Preformed
- Hemodialysis
Conditions Treated
- Calcium Metabolism Disorders
- Chronic Kidney Diseases
- Congenital Cystic Kidney Disease
- Congenital Polycystic Kidney Disease
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Doctors Specialties
- Nephrology
Accepted Insurances
Education
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University of Louisville -
U Louisville SOM -
University of Kansas School of Medicine -
University of Texas Medical Branch
Hospital
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Jewish Hospital -
Norton Hospital -
University of Louisville Hospital
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