Director, Center for Gene Therapy, Hematologic Institute, City of Hope
Pediatric Infectious Disease
Dr. John Zaia, MD
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Dr. John Zaia works in the field of Pediatric Infectious Disease. He attended Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 7 awards "Scientific Research Portrait Gallery", "Chairman", "Aaron D. and Edith Miller Chair in Gene Therapy", "Innovative Pre-Clinical and Clinical Program for AIDS Research", "director", "Young Investigator Award" and "National Science Foundation Summer Fellowship". John Zaia is a published doctor and has 101 publications published. The lastest was: 'Comparison of amphotropic and pseudotyped VSV-G retroviral transduction in human CD34+ peripheral blood progenitor cells from adult donors with HIV-1 infection or cancer.'
Publications
- Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-ce...
- Practical Considerations in Gene Therapy for HIV Cure.
- Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases.
- Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma.
- Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an ess...
- Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections.
- Towards an HIV cure: a global scientific strategy.
- Design of HIV vectors for efficient gene delivery into human hematopoietic cells.
- Characterization of cytotoxic function of CMV-pp65-specific CD8+ T-lymphocytes identified by HLA tetramers in recipients and donors of stem-cell transplants.
- Prevention of cytomegalovirus disease in hematopoietic stem cell transplantation.
- A nucleolar TAR decoy inhibitor of HIV-1 replication.
- Enhanced expression and HIV-1 inhibition of chimeric tRNA(Lys3)-ribozymes under dual U6 snRNA and tRNA promoters.
- Use of transgenic HLA A*0201/Kb and HHD II mice to evaluate frequency of cytomegalovirus IE1-derived peptide usage in eliciting human CD8 cytokine response.
- Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles.
- Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors.
- DNA and low titer, helper-free, recombinant AAV prime-boost vaccination for cytomegalovirus induces an immune response to CMV-pp65 and CMV-IE1 in transgenic HLA A*0201...
- Lack of association of cytomegalovirus with human brain tumors.
- Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients.
- Current status of gene therapy strategies to treat HIV/AIDS.
- Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection.
- Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, ...
- Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ tra...
- RNA-mediated inhibition of HIV in a gene therapy setting.
- Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants.
- The status of gene vectors for the treatment of diabetes.
- The effect of single and combined activating killer immunoglobulin-like receptor genotypes on cytomegalovirus infection and immunity after hematopoietic cell transplan...
- Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients.
- Biologic and immunologic effects of knockout of human cytomegalovirus pp65 nuclear localization signal.
- Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.
- Death in a gene-therapy trial.
- HIV status does not affect the outcome of autologous stem cell transplantation (ASCT) for non-Hodgkin lymphoma (NHL).
- Immune monitoring with iTAg MHC Tetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transpla...
- RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.
- Expression of activating KIR2DS2 and KIR2DS4 genes after hematopoietic cell transplantation: relevance to cytomegalovirus infection.
- Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation.
- Donor and recipient CMV serostatus and outcome of pediatric allogeneic HSCT for acute leukemia in the era of CMV-preemptive therapy.
- Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010.
- Institution affects association between CMV seronegative graft and leukemic relapse after pediatric HCT.
- Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy.
- Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas.
- Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells.
- Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and...
- Treatment of human immunodeficiency virus-related lymphoma with haematopoietic stem cell transplantation.
- Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.
- Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies.
- Stem cell transplantation and gene therapy for HIV-related lymphomas.
- Infrequent occurrence of natural mutations in the pp65(495-503) epitope sequence presented by the HLA A*0201 allele among human cytomegalovirus isolates.
- Site-directed mutation in a conserved kinase domain of human cytomegalovirus-pp65 with preservation of cytotoxic T lymphocyte targeting.
- Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after alloge...
- Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follo...
- Plasma polymerase chain reaction for cytomegalovirus DNA after allogeneic marrow transplantation: comparison with polymerase chain reaction using peripheral blood leuk...
- Late cytomegalovirus disease in marrow transplantation is predicted by virus load in plasma.
- Status of ribozyme and antisense-based developmental approaches for anti-HIV-1 therapy.
- A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hop...
- Ganciclovir/immunoglobulin combination therapy for the treatment of human cytomegalovirus-associated interstitial pneumonia in bone marrow allograft recipients.
- A study of the pharmacokinetics, antiviral activity, and tolerability of oral ganciclovir for CMV prophylaxis in marrow transplantation.
- Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene.
- A chimeric tRNA(Lys3)-ribozyme inhibits HIV replication following virion assembly.
- Direct DNA immunization of mice with plasmid DNA encoding the tegument protein pp65 (ppUL83) of human cytomegalovirus induces high levels of circulating antibody to th...
- Comparison of amphotropic and pseudotyped VSV-G retroviral transduction in human CD34+ peripheral blood progenitor cells from adult donors with HIV-1 infection or cancer.
- Prevention and treatment of cytomegalovirus pneumonia in transplant recipients.
- Evaluation of a quantitative plasma PCR plate assay for detecting cytomegalovirus infection in marrow transplant recipients.
- Kinase-deficient CMVpp65 triggers a CMVpp65 specific T-cell immune response in HLA-A*0201.Kb transgenic mice after DNA immunization.
- Virion encapsidation of tRNA(3Lys)-ribozyme chimeric RNAs inhibits HIV infection.
- Autologous stem cell transplantation for HIV-associated lymphoma.
- Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters.
- A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector.
- Characterization of a 52K protein of murine cytomegalovirus and its immunological cross-reactivity with the DNA-binding protein ICP36 of human cytomegalovirus.
- Comparative analysis of human cytomegalovirus a-sequence in multiple clinical isolates by using polymerase chain reaction and restriction fragment length polymorphism ...
- Cytomegalovirus infection in the bone marrow transplant recipient.
- Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune respon...
- Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected ...
- Viral disease prevention after hematopoietic cell transplantation.
- Ribozymes as therapies for AIDS.
- Prospects for gene therapy using HIV-based vectors.
- Ribozymes as anti-HIV-1 therapeutic agents: principles, applications, and problems.
- Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation.
- Prolonged human cytomegalovirus viremia following bone marrow transplantation.
- Polypeptide-specific antibody response to human cytomegalovirus after infection in bone marrow transplant recipients.
- Increased Leu-7-positive T lymphocytes during cytomegalovirus infection following allogeneic bone marrow transplantation for hematologic malignancies.
- Altered expression of fibronectin gene in cells infected with human cytomegalovirus.
- Hematopoietic potential and retroviral transduction of CD34+ Thy-1+ peripheral blood stem cells from asymptomatic human immunodeficiency virus type-1-infected individu...
- Quantitation of human cytomegalovirus DNA in lungs from bone marrow transplant recipients with interstitial pneumonia.
- Bone marrow transplantation for acute nonlymphoblastic leukemia during first complete remission. An analysis of prognostic factors.
- Cyclosporine does not prevent in vivo expression of T cell activation antigens following allogeneic bone marrow transplantation.
- Treatment and prevention of cytomegalovirus pneumonia after bone marrow transplantation: where do we stand?
- Ribozymes as potential anti-HIV-1 therapeutic agents.
- Prevention and management of CMV-related problems after hematopoietic stem cell transplantation.
- High dose therapy and autologous stem cell transplantation for human immunodeficiency virus-associated non-Hodgkin lymphoma in the era of highly active antiretroviral ...
- Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes.
- Structural analysis of a 64-kDa major structural protein of human cytomegalovirus (Towne): identification of a phosphorylation site and comparison to pp65 of HCMV (AD1...
- Comparison of plasma PCR and bronchoalveolar lavage fluid culture for detection of cytomegalovirus infection in adult bone marrow transplant recipients.
- Human cytomegalovirus strain Towne pp65 gene: nucleotide sequence and expression in Escherichia coli.
- Human cytomegalovirus-associated pneumonitis: pathogenesis, prevention, and treatment.
- Exploring the use of antisense, enzymatic RNA molecules (ribozymes) as therapeutic agents.
- Expression in insect cells and immune reactivity of a 28K tegument protein of human cytomegalovirus.
- Human cytomegalovirus strain Towne pp28 gene: sequence comparison to pp28 of HCMV AD169 and stable expression in Chinese hamster ovary cells.
- Genomic locus for a 140 kDa structural protein (pp150) of human cytomegalovirus in strains Towne and AD169.
- Should HIV-positive patients with lymphoma be offered stem cell transplants?
- Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes.
Schools
Harvard University Medical School
St Louis Childrens Hospital
ChildrenS Hospital Medical Center
Dana Farber Cancer Institute
Doctors Specialties
- Pediatric Infectious Disease
Accepted Insurances
Awards
- Scientific Research Portrait Gallery
- Chairman
- Aaron D. and Edith Miller Chair in Gene Therapy
- Innovative Pre-Clinical and Clinical Program for AIDS Research
- director
- Young Investigator Award
- National Science Foundation Summer Fellowship
Education
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Boston Children's Hospital -
Harvard Medical School -
Dartmouth College
Hospital
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City of Hope's Helford Clinical Research Hospital
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