Professor, Internal Medicine, Washington University in St. Louis School of Medicine
Family Medicine
Dr. John O. Holloszy, MD
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John Holloszy is an expert in the field of Family Medicine. He went to Washington University School of Medicine in St. Louis. He over the years received 1 awards: "Elected Member". John Holloszy is a published MD. He has 101 publications published. The most current publication "Effect of prolonged exercise on muscle citrate concentration before and after endurance training in men."
Publications
- Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.
- PGC-1α Mediates a Rapid, Exercise-Induced Down Regulation of Glycogenolysis in Rat Skeletal Muscle.
- Multiple dietary supplements do not affect metabolic and cardio-vascular health.
- Postprandial Plasma Incretin Hormones in Exercise-Trainedversus Untrained Subjects.
- Multiple dietary supplements do not affect metabolic and cardiovascular health.
- Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation.
- "Deficiency" of mitochondria in muscle does not cause insulin resistance.
- ?-Adrenergic Stimulation Does Not Activate p38 MAPKinase or Induce PGC-1? in Skeletal Muscle.
- Normal Adaptations to Exercise Despite Protection Against Oxidative Stress.
- Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans.
- Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.
- Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans.
- Does calorie restriction induce mitochondrial biogenesis? A reevaluation.
- Deficiency of the mitochondrial electron transport chain in muscle does not cause insulin resistance.
- Is "fat-induced" muscle insulin resistance rapidly reversible?
- Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus.
- Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.
- IGF-1, nutrition and aging: the big picture.
- Exercise: it's the real thing!
- Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance.
- Influence of weekend lifestyle patterns on body weight.
- Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day.
- High-fat diets cause insulin resistance despite an increase in muscle mitochondria.
- The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.
- A role for the transcriptional coactivator PGC-1alpha in muscle refueling.
- Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images.
- Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activ...
- Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.
- IL-6 increases muscle insulin sensitivity only at superphysiological levels.
- Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk.
- Improvements in body composition, glucose tolerance, and insulin action induced by increasing energy expenditure or decreasing energy intake.
- Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression.
- Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.
- Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk.
- How muscle insulin sensitivity is regulated: testing of a hypothesis.
- DHEA enhances effects of weight training on muscle mass and strength in elderly women and men.
- Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life.
- Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.
- Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.
- Role of calcineurin in exercise-induced mitochondrial biogenesis.
- PPARdelta activator GW-501516 has no acute effect on glucose transport in skeletal muscle.
- Abdominal adiposity is a stronger predictor of insulin resistance than fitness among 50-95 year olds.
- Long-term caloric restriction ameliorates the decline in diastolic function in humans.
- Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport?
- Effects of progressive resistance training on body composition in frail older adults: results of a randomized, controlled trial.
- Exercise-induced increase in muscle insulin sensitivity.
- Modest weight loss improves insulin action in obese African Americans.
- Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle.
- PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
- Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin.
- Low bone mass in subjects on a long-term raw vegetarian diet.
- Calcineurin does not mediate exercise-induced increase in muscle GLUT4.
- A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.
- Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds.
- Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.
- Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner.
- Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
- Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.
- Adaptations of skeletal muscle mitochondria to endurance exercise: a personal perspective.
- UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction.
- Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.
- Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle.
- Attenuation of cardiovascular adaptations to exercise in frail octogenarians.
- Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise.
- Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity.
- A peroxovanadium compound stimulates muscle glucose transport as powerfully as insulin and contractions combined.
- Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle.
- A forty-year memoir of research on the regulation of glucose transport into muscle.
- Divergent effects of acute exercise and endurance training on UCP3 expression.
- Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis.
- Effects of exercise training on frailty in community-dwelling older adults: results of a randomized, controlled trial.
- Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.
- Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells.
- Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice.
- Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation.
- Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+).
- Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.
- Differences in cardiovascular adaptations to endurance exercise training between older men and women.
- Persistent increase in glucose uptake by rat skeletal muscle following exercise.
- Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise.
- Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin.
- Effects of age, adiposity, and fitness level on plasma catecholamine responses to standing and exercise.
- Increased permeability to sugar following muscle contraction. Inhibitors of protein synthesis prevent reversal of the increase in 3-methylglucose transport rate.
- Relationship between glucose tolerance and glucose-stimulated insulin response in 65-year-olds.
- Effect of muscle glycogen content on glucose uptake following exercise.
- Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle.
- Muscle metabolism during exercise.
- Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle.
- Circulating reverse triiodothyronine in humans during exercise.
- Histochemical and physiological correlates of training- and detraining-induced changes in the recovery from a fatigue test.
- Time course of the adaptive responses of aerobic power and heart rate to training.
- Body composition of physically inactive and active 25-month-old female rats.
- Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease.
- Insulin resistance in aging is related to abdominal obesity.
- A physiological comparison of young and older endurance athletes.
- Adaptation of muscle to creatine depletion: effect on GLUT-4 glucose transporter expression.
- Faster adjustment to and recovery from submaximal exercise in the trained state.
- Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle.
- Effects of beta-guanidinopropionic acid-feeding on the patterns of myosin isoforms in rat fast-twitch muscle.
- Effect of prolonged exercise on muscle citrate concentration before and after endurance training in men.
Schools
Washington Center School of Medicine
Doctors Specialties
- Internal Medicine
- Preventive Medicine
- Family Medicine
Accepted Insurances
Awards
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis
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