Physician
Dermatology
Dr. John M. Tomich, MD
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John M. Tomich works in the field of Dermatology. He researched medicine at University of Michigan Medical School. He over the years received 1 awards: "Fellow (FAAD)". John M. Tomich, MD is also a published doctor. He has 100 paper published. The most recent paper is: Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function. John Tomich accepts all Medicare patients.
Publications
- Characterisation and stability of anthocyanins in purple-fleshed sweet potato P40.
- Branched Amphiphilic Cationic Oligopeptides Form Peptiplexes with DNA: A Study of Their Biophysical Properties and Transfection Efficiency.
- Thermally induced conformational transitions in nascent branched amphiphilic Peptide capsules.
- Trapping of Intermediates with Substrate Analog HBOCoA in the Polymerizations Catalyzed by Class III Polyhydroxybutyrate (PHB) Synthase from Allochromatium Vinosum.
- Reduced signaling of PI3K-Akt and RAS-MAPK pathways is the key target for weight-Loss-induced cancer prevention by dietary calorie restriction and/or physical activity.
- Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes.
- Free Energy Analysis of Conductivity and Charge Selectivity of M2GlyR-Derived Synthetic Channels.
- Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal Cancer prevention.
- Branched oligopeptides form nanocapsules with lipid vesicle characteristics.
- Effect of Diaminopropionic Acid (Dap) on the Biophysical Properties of a Modified Synthetic Channel-Forming Peptide.
- Proteomic and Transcriptomic Analyses of Rigid and Membranous Cuticles and Epidermis from the Elytra and Hindwings of the Red Flour Beetle, Tribolium castaneum.
- Comparative proteomics uncovers the signature of natural selection acting on the ejaculate proteomes of two cricket species isolated by postmating, prezygotic phenotypes.
- Domain V peptides inhibit beta2-glycoprotein I-mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation.
- Structural characterization of two pore-forming peptides: consequences of introducing a C-terminal tryptophan.
- Tribolium castaneum larval gut transcriptome and proteome: A resource for the study of the coleopteran gut.
- NC-1059: a channel-forming peptide that modulates drug delivery across in vitro corneal epithelium.
- Identification, RNAi knockdown, and functional analysis of an ejaculate protein that mediates a postmating, prezygotic phenotype in a cricket.
- Design of 11-residue peptides with unusual biophysical properties: induced secondary structure in the absence of water.
- Epithelial barrier modulation by a channel forming peptide.
- Immunity to a self-derived, channel-forming peptide in the respiratory tract.
- Redesigning channel-forming peptides: amino acid substitutions that enhance rates of supramolecular self-assembly and raise ion transport activity.
- Conformation and environment of channel-forming peptides: a simulation study.
- Adhesion and structure properties of protein nanomaterials containing hydrophobic and charged amino acids.
- NMR structure and dynamic studies of an anion-binding, channel-forming heptapeptide.
- Channel-forming peptide modulates transepithelial electrical conductance and solute permeability.
- Activity and structural comparisons of solution associating and monomeric channel-forming peptides derived from the glycine receptor m2 segment.
- Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR.
- An ABC Transporter Is Required for Secretion of Peptide Sex Pheromones in Enterococcus faecalis.
- Inhibition of in vitro transcription by specific double-stranded oligodeoxyribonucleotides.
- Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy.
- Corrected sequence of the mannitol (mtl) operon in Escherichia coli.
- Molecular biology of glucocerebrosidase and the treatment of Gaucher disease.
- Cyclic AMP, glucocorticoid, and retinoid modulation of in vitro keratinocyte growth.
- Hydatid cyst: an unusual cause of diplopia.
- Identification of TNF-LT blocking factor(s) in the serum and ultrafiltrates of human Cancer patients.
- Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltr...
- Saposins (sphingolipid activator proteins) in the twitcher mutant mouse.
- Glycosaparaginase from human leukocytes. Inactivation and covalent modification with diazo-oxonorvaline.
- Interaction of saposins, acidic lipids, and glucosylceramidase.
- A synthetic peptide based on a glycine-gated chloride channel induces a novel chloride conductance in isolated epithelial Cells.
- Cytostatic inhibition of cancer Cell growth by lignan secoisolariciresinol diglucoside.
- A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis.
- Total, membrane, and immunogenic proteomes of macrophage- and tick Cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and M...
- A synthetic peptide derived from glycine-gated Cl- channel induces transepithelial Cl- and fluid secretion.
- Synthetic mutants of Clostridium pasteurianum ferredoxin: open iron sites and testing carboxylate coordination.
- Physical characterization of a totally synthetic rubredoxin.
- Membrane topography and near-neighbor relationships of the mitochondrial ATP synthase subunits e, f, and g.
- The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor.
- Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2).
- Synthesis and characterization of a bioactive 82-residue sphingolipid activator protein, saposin C.
- Key of induced tolerance to ischaemia in gerbil hippocampal CA1 is not at transcriptional level of hsp70 gene: in Situ hybridization of hsp70 mRNA.
- ATP synthase complex. Proximities of subunits in bovine submitochondrial particles.
- Use of the 3-nitro-2-pyridine sulfenyl protecting group to introduce N epsilon-branching at lysine during solid-phase peptide synthesis. I. Application to the synthesi...
- Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.
- Identification of the neurotrophic factor sequence of prosaposin.
- Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycin...
- Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cho...
- Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor.
- Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase.
- Position of the sulfhydryl group and the disulfide bonds of human glucocerebrosidase.
- Chemical synthesis and characterization of peptides and oligomeric proteins designed to form transmembrane ion channels.
- Identification of an ion channel-forming motif in the primary structure of CFTR, the cystic fibrosis chloride channel.
- Design of a functional calcium channel protein: inferences about an ion channel-forming motif derived from the primary structure of voltage-gated calcium channels.
- Modification of two essential cysteines in rabbit muscle pyruvate kinase by the guanine nucleotide analogue 5'[p-(fluorosulfonyl) benzoyl] guanosine.
- Evidence for distinguishable sites of attack in the reactions of 5'-p-fluorosulfonylbenzoyl adenosine and 5'-p-fluorosulfonylbenzoyl guanosine with rabbit muscle pyruv...
- Insertion of the mannitol permease into the membrane of Escherichia coli. Possible involvement of an N-terminal amphiphilic sequence.
- A simple nonisotopic in vitro bioassay for LT and TNF employing sodium fluoride-treated L-929 target Cells that detects picogram quantities of LT and TNF and is as sen...
- Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructok...
- Mitochondrial ATP synthase complex. Membrane topography and stoichiometry of the F0 subunits.
- Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor function...
- A molecular blueprint for the pore-forming structure of voltage-gated calcium channels.
- Characterization of human glucocerebrosidase from different mutant alleles.
- Synporins--synthetic proteins that emulate the pore structure of biological ionic channels.
- A totally synthetic histidine-2 ferredoxin: thermal stability and redox properties.
- Insertion and folding of the amino-terminal amphiphilic signal sequences of the mannitol and glucitol permeases of Escherichia coli.
- Identification of an ion channel-forming motif in the primary structure of tetanus and botulinum neurotoxins.
- Synthetic peptides and proteins as models for pore-forming structure of channel proteins.
- Molecular design of oligomeric channel proteins.
- Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria.
- Plasmin-mediated proteolysis of casein in bovine milk.
- A synthetic channel-forming peptide induces Cl(-) secretion: modulation by Ca(2+)-dependent K(+) channels.
- Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function.
- Structure and evolution of a multidomain multiphosphoryl transfer protein. Nucleotide sequence of the fruB(HI) gene in Rhodobacter capsulatus and comparisons with homo...
- Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in Cell lines with and without enzyme activity.
- Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.
- Diagnoses of Skin disease: dermatologists vs. nondermatologists.
- Electrolysis and thermolysis for permanent Hair removal.
- Reaction of 5''-p-fluorosulfonylbenzoyl-1,N6-ethenoadenosine with histidine and cysteine residues in the active site of rabbit muscle pyruvate kinase.
- Late recurrent Basal cell carcinoma presenting as a unilateral exophthalmos.
- Amphiphilicity is essential for mitochondrial presequence function.
- Prevention of aggregation of synthetic membrane-spanning peptides by addition of detergent.
- A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers.
- Membrane incorporation and induction of secondary structure of synthetic peptides corresponding to the N-terminal signal sequences of the glucitol and mannitol permeas...
- The M2 delta transmembrane domain of the nicotinic cholinergic receptor forms ion channels in human erythrocyte membranes.
- Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
- NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion.
- Expression of an artificial Cl- channel in microperfused renal proximal tubules.
- Structural implications of placing cationic residues at either the NH2- or COOH-terminus in a pore-forming synthetic peptide.
- Identification and quantification of anthocyanins in transgenic purple tomato.
Schools
University of Mi Med Sch
University Hospital
Procedures Preformed
- Adjacent Tissue Transfer
- Destruction of Benign Skin Lesion
- Destruction of Malignant Skin Lesion
- Destruction of Penile Lesion
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Conditions Treated
- Acne
- Actinic Keratosis
- Atopic Dermatitis (Eczema)
- Basal Cell Carcinoma
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Doctors Specialties
- Dermatology
Accepted Insurances
Awards
- Fellow (FAAD)
Education
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Boston University Medical Center -
University of Michigan Medical School
Hospital
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Hallmark Health System -
Winchester Hospital
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