Chief, Section of Allergy and Clinical Immunology, Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College Wisconsin
Allergy & Immunology
Dr. John M. Routes, MD
|
|
Give Review
Dr. John M. Routes works in the field of Allergy & Immunology. He graduated from Indiana University School of Medicine. Indiana University School of Medicine has a rank of 45 in research and a 47 in primary care He over the years received 9 awards: "America's Top Doctors", "President", "Top Doctors", "Fellow", "Pioneer in Newborn Screening-Dream Maker Award", "Health Care Hero Award", "Fellow (FAAAAI)", "Super Doctor" and "Best Doctors". John Routes is a published doctor as well. He has 69 publications published. The latest was: Studies on nicotinic acetylcholine receptors in mammalian brain. Preliminary characterization of membrane-bound alpha-bungarotoxin receptors in rat cerebral cortex. He is registered with Medicare and accepts Medicare payments.
Publications
- ICON: Common Variable Immunodeficiency Disorders.
- Screening for and Treatments of Congenital ImmunoDeficiency Diseases.
- Newborn screening for SCID: where are we now?
- Sarcoidosis and Common variable immunodeficiency: similarities and differences.
- Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts.
- ICON: The Early Diagnosis of Congenital Immunodeficiencies.
- A172: Metaphyseal Chondrodysplasia, Ectodermal Dysplasia, Short Stature, Hypergammaglobulinemia, and Spontaneous Inflammation Without Infections in an Extended Family ...
- Inflammatory Signals Direct Expression of Human IL12RB1 into Multiple Distinct Isoforms.
- Use of Combination Chemotherapy for Treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in Patients with Common Variable Immunodeficiency (CVID).
- Newborn Screening for Severe Combined ImmunoDeficiency; The Wisconsin Experience (2008-2011).
- Newborn screening for SCID: three years of experience.
- Global study of primary immunoDeficiency diseases (PI)-diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation.
- Cause of Death in Neonates with Inconclusive or Abnormal T-cell Receptor Excision Circle Assays on Newborn Screening.
- Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease.
- Newborn screening for T-cell Deficiency.
- Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease.
- Implementing routine testing for severe combined immunoDeficiency within Wisconsin's newborn screening program.
- Improving cellular therapy for primary Immune deficiency diseases: recognition, diagnosis, and management.
- Statewide newborn screening for severe T-cell lymphopenia.
- Development of a routine newborn screening protocol for severe combined immunoDeficiency.
- E1A oncogene enhancement of caspase-2-mediated mitochondrial injury sensitizes cells to macrophage nitric oxide-induced apoptosis.
- ImmunoDeficiency overview.
- The interaction of adenovirus E1A with p300 family members modulates cellular gene expression to reduce tumorigenicity.
- Measurement of natural-killer cell lytic activity of adenovirus-infected or adenovirus-transformed cells.
- Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.
- UnCommon conundrum in Common variable immunodeficiency.
- Granulomatous disease in Common variable immunodeficiency.
- Possible role of human herpesvirus 8 in the lymphoproliferative disorders in Common variable immunodeficiency.
- Adenovirus E1A gene-induced tumor cell rejection through cellular sensitization to Immune and nonImmune apoptotic injuries.
- Macrophages kill human papillomavirus type 16 E6-expressing tumor cells by tumor necrosis factor alpha- and nitric oxide-dependent mechanisms.
- Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract.
- Granulomatous-lymphocytic lung disease shortens survival in Common variable immunodeficiency.
- Expression of an E1A/E7 chimeric protein sensitizes tumor cells to killing by activated macrophages but not NK cells.
- Expression of human herpesvirus 8 in primary pulmonary hypertension.
- E1A oncogene-induced sensitization of human tumor cells to innate Immune defenses and chemotherapy-induced apoptosis in vitro and in vivo.
- Adenovirus E1A, not human papillomavirus E7, sensitizes tumor cells to lysis by macrophages through nitric oxide- and TNF-alpha-dependent mechanisms despite up-regulat...
- E1A oncogene induction of cellular susceptibility to killing by cytolytic lymphocytes through target cell sensitization to apoptotic injury.
- Lack of correlation between Chlamydia pneumoniae antibody titers and adult-onset Asthma.
- Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL).
- Dissimilar immunogenicities of human papillomavirus E7 and adenovirus E1A proteins influence primary tumor development.
- CREB (cAMP response element binding protein) and C/EBPalpha (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase...
- MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection.
- Role of the innate Immune response in determining the tumorigenicity of neoplastic cells.
- Corticosteroids in inflammatory bowel disease. A review.
- Studies on nicotinic acetylcholine receptors in mammalian brain. Preliminary characterization of membrane-bound alpha-bungarotoxin receptors in rat cerebral cortex.
- Adenovirus serotype 5 E1A expressing tumor cells elicit a tumor-specific CD8+ T cell response independent of NKG2D.
- Screening for severe combined immunoDeficiency in neonates.
- Possible role of arginase-1 in concomitant tumor immunity.
- Practice parameter for the diagnosis and management of primary immunoDeficiency.
- Screening newborns for primary T-cell immunodeficiencies: consensus and controversy.
- Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia.
- Pulmonary infection with Mycobacterium neoaurum identified by 16S ribosomal DNA sequence.
- Pre-event smallpox vaccination and postevent exposure and disease: a report of the Joint Task Force on Smallpox Vaccination for Allergists.
- IFN increases class I MHC antigen expression on adenovirus-infected human cells without inducing resistance to natural killer cell killing.
- Diffuse pulmonary infiltrates in Hypogammaglobulinemia.
- Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene.
- Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity.
- Adenovirus persistence in man. Defective E1A gene product targeting of infected cells for elimination by natural killer cells.
- Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells.
- E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells.
- Adenovirus E1A inhibits IFN-induced resistance to cytolysis by natural killer cells.
- Oral desensitization to rifampin and ethambutol in mycobacterial disease.
- Activities of superoxide dismutases and NADPH oxidase in neutrophils obtained from Asthmatic and normal donors.
- Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression.
- Inhibition of IFN-stimulated gene expression and IFN induction of cytolytic resistance to natural killer cell lysis correlate with E1A-p300 binding.
- Adenovirus E1A proteins regulate phosphoenolpyruvate carboxykinase gene transcription through multiple mechanisms.
- Hypersensitivity pneumonitis in a patient with Hypogammaglobulinemia.
- Noninfectious immunologic disorders in adults.
Schools
Indiana University School Of Medicine
University of Utah
National Jewish Medical and Research Center
Procedures Preformed
- Allergy Shots
- Patch Testing
Conditions Treated
- Allergic Rhinitis
- Angioedema
- Asthma
- Chronic Sinusitis
- View All
Doctors Specialties
- Allergy
- Immunology
Accepted Insurances
Awards
- America's Top Doctors
- President
- Top Doctors
- Fellow
- Pioneer in Newborn Screening-Dream Maker Award
- Health Care Hero Award
- Fellow (FAAAAI)
- Super Doctor
- Best Doctors
Education
-
University of Colorado -
University of Utah -
Indiana University School of Medicine
Hospital
-
Children's Hospital of Wisconsin -
Froedtert Memorial Lutheran Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1396792891 |
| Last Name Of The Provider | ROUTES |
| First Name Of The Provider | JOHN |
| View All |
Similar Doctors
|
Dr. Heidi Zafra, MD
 This Doctor is OpenDoctor Recommended.
|
|
Dr. Jordan N. Fink, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Gene Schwartz, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. David Y. Rosenzweig, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Joshua A. Steinberg, MD
This Doctor is OpenDoctor Recommended.
|