Neuropathologist at McLean Hospital Brain Bank (Harvard Brain Tissue resource Center)
Pathology
Dr. John C. Hedreen, MD
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John C. Hedreen works in the field of Pathology. He researched medicine at Case Western Reserve University School of Medicine. John C. Hedreen, MD is a published physician. He published 69 publications, including: 'What was wrong with the Abercrombie and empirical cell counting methods? A review.'
Publications
- SDF-1alpha is expressed in astrocytes and neurons in the AIDS dementia complex: an in vivo and in vitro study.
- TorsinA protein and neuropathology in early onset generalized dystonia with GAG deletion.
- PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.
- Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis.
- Corticostriatal cells identified by the peroxidase method.
- TorsinB expression in the developing human brain.
- HIV leucoencephalopathy and TNFalpha expression in neurones.
- TorsinA expression is detectable in human infants as young as 4 weeks old.
- Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia.
- Observations on labeling of neuronal cell bodies, axons, and terminals after injection of horseradish peroxidase into rat brain.
- Tau protein expression in frontotemporal dementias.
- Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficien...
- Unbiased stereology?
- Tyrosine hydroxylase-immunoreactive elements in the human globus pallidus and subthalamic nucleus.
- What was wrong with the Abercrombie and empirical cell counting methods? A review.
- Lost caps in histological counting methods.
- Centenary of Gaule and Lewin, pioneers in cell counting methodology.
- Accuracy of clinical diagnosis of Alzheimer disease and clinical features of patients with non-Alzheimer disease neuropathology.
- Lack of association of the apoE4 allele with hippocampal sclerosis dementia.
- Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly in...
- The locus ceruleus and dementia in Parkinson's disease.
- Phosphorylated neurofilaments in neuronal perikarya and dendrites in human brain following axonal damage.
- The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease.
- Early loss of neostriatal striosome neurons in Huntington's disease.
- A quick silver method for senile plaques and neurofibrillary tangles in paraffin sections.
- Comparison of new and traditional methods for detection of senile plaques in Alzheimer's disease.
- Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.
- Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington''s disease patients.
- Neuronal loss from the subthalamic nuclei in a patient with progressive chorea.
- RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.
- Selective loss of [3H]kainic acid and [3H]AMPA binding in layer VI of frontal cortex in Huntington's disease.
- Homotopic and heterotopic callosal afferents of caudal inferior parietal lobule in Macaca mulatta.
- Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system.
- Basal forebrain neurons in the dementia of Parkinson disease.
- Pick's disease (lobar sclerosis): depletion of neurons in the nucleus basalis of Meynert.
- Synaptic neurochemistry of the basal forebrain cholinergic projection.
- Neuroanatomical evidence for a cholinergic deficit in Alzheimer's disease.
- Acetylcholinesterase activity in senile plaques of aged macaques.
- Acetylcholinesterase-immunoreactive axonal network in monkey visual cortex.
- Immunocytochemical identification of cholinergic neurons in the monkey central nervous system using monoclonal antibodies against choline acetyltransferase.
- Topography of the magnocellular basal forebrain system in human brain.
- The nucleus basalis in Huntington's disease.
- Alzheimer's disease and Down's syndrome.
- Retrograde and anterograde axonal transport demonstrated by intracerebral injection of a labeled protein-acylating agent.
- Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16.
- Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study.
- Parkinson's disease: loss of neurons from the ventral tegmental area contralateral to therapeutic surgical lesions.
- Pathology in brainstem regions of individuals with primary dystonia.
- Brain stem pathology in cranial dystonia.
- The neuropathology of aminergic nuclei in Alzheimer's disease.
- Primary dystonias: a review of the pathology and suggestions for new directions of study.
- Alzheimer's disease and related dementias: selective involvement of specific neuronal systems.
- Sigma receptors in post-mortem human brains.
- Neuropathology of aminergic nuclei in Alzheimer's disease.
- A modified histochemical technique to visualize acetylcholinesterase-containing axons.
- The pedunculopontine nucleus in Parkinson's disease.
- Linkage to the Huntington's disease locus in a family with unusual clinical and pathological features.
- Selective silver impregnation of senile plaques: a method useful for computer imaging.
- Nigral dopamine type-1 receptors are reduced in Huntington's disease: a postmortem autoradiographic study using [3H]SCH 23390 and correlation with [3H]forskolin binding.
- Organization of striatopallidal, striatonigral, and nigrostriatal projections in the macaque.
- Hippocampal lesions in dominantly inherited Alzheimer's disease.
- Neuronal loss in layers V and VI of cerebral cortex in Huntington''s disease.
- Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.
- Locus coeruleus involvement in Huntington's disease.
- Evidence for a hippocampal-septal glutamatergic pathway in the rat.
- Neuronal degeneration caused by lateral ventricular injection of 6-hydroxy-dopamine. I. The ventral premammillary nucleus and other cell groups.
- Terminal degeneration demonstrated by the Fink-Heimer method following lateral ventricular injection of 6-hydroxydopamine.
- NFkappaB activation, TNF-alpha expression, and apoptosis in the AIDS-Dementia-Complex.
Schools
Case Western Reserve University School of Medicine
Johns Hopkins University School Med
Johns Hopkins
Doctors Specialties
- Neuropathology
- Pathology
Accepted Insurances
Education
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Johns Hopkins University -
Case Western Reserve University School of Medicine