Professor of Neurology, Washington University St Louis
Neurology
Dr. Joel S. Perlmutter, MD
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Joel S. Perlmutter, MD works in the field of Neurology. He studied medicine at University of Missouri-Columbia School of Medicine. He received awards:"America's Top Doctors", "St. Louis Magazine: Top Doctors" and "Top MD". Joel Perlmutter is also published. He has 101 publications published. The lastest publication: "HDQLIFE: the development of two new computer adaptive tests for use in Huntington disease, Speech Difficulties, and Swallowing Difficulties.'
Publications
- Clinimetric testing of the comprehensive cervical Dystonia rating scale.
- Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates.
- Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.
- Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.
- Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase10A in the brain of living subject.
- In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter.
- Secured web-based video repository for multicenter studies.
- Neuroimaging biomarkers for Parkinson Disease: Facts and fantasy.
- Radiosynthesis and in vivo evaluation of a novel Ï1 selective PET ligand.
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's Disease.
- Correlation between decreased CSF α-synuclein and Aβ1-42 in Parkinson Disease.
- In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment.
- Carboxyfullerene neuroprotection post injury in parkinsonian nonhuman primates.
- Functional anatomy of subthalamic nucleus stimulation in Parkinson Disease.
- Acute Changes in Mood Induced by Subthalamic Deep Brain Stimulation in Parkinson Disease Are Modulated by Psychiatric Diagnosis.
- Comment: fMRI biomarker for premanifest HD?
- A rare sequence variant in intron 1 of THAP1 is associated with primary Dystonia.
- Syntheses and Radiosyntheses of Two Carbon-11 Labeled Potent and Selective Radioligands for Imaging Vesicular Acetylcholine Transporter.
- In Vitro and In Vivo Characterization of Two C-11-Labeled PET Tracers for Vesicular Acetylcholine Transporter.
- Visuomotor adaptation in Parkinson's Disease: Effects of perturbation type and medication state.
- Levodopa-Responsive Hemiparkinsonism Secondary to Cystic Expansion from a Coiled Cerebral Aneurysm.
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit.
- Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate.
- Disparities in deep brain stimulation surgery among insured elders with Parkinson Disease.
- Brain activity during complex imagined gait tasks in Parkinson Disease.
- Striatal dopamine D1-like receptor binding is unchanged in primary focal Dystonia.
- Principal component analysis of PiB distribution in Parkinson and Alzheimer Diseases.
- Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.
- The focal Dystonias: Current views and challenges for future research.
- Validation of midbrain PET measures for nigrostriatal neurons in macaques.
- Parkinson Disease is not associated with C9ORF72 repeat expansions.
- A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11) C]methyl)benperidol.
- Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's Disease.
- Binding of the Radioligand SIL23 to ?-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson D...
- Erratum to: Radiation dosimetry of N-([(11)C]methyl)benperidol as determined by whole-body PET imaging of primates.
- Reply: Levodopa increases functional connectivity in the cerebellum and brainstem in Parkinson's Disease.
- Positron emission tomography imaging of dopamine D(2) receptors using a highly selective radiolabeled D(2) receptor partial agonist.
- Resting state functional connectivity of the striatum in Parkinson's Disease.
- Oromandibular and lingual dystonia associated with spinocerebellar Ataxia type 8.
- Validation of nigrostriatal positron emission tomography measures: Critical limits.
- Pathologic accumulation of α-synuclein and Aβ in Parkinson Disease patients with dementia.
- Predictors of Survival in Patients With Parkinson Disease.
- Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure.
- MRI measures predict Progressive supranuclear palsy: Clinically useful?
- Metabolic control of resting hemispheric Cerebral blood flow is oxidative, not glycolytic.
- The c.-237_236GA>TT THAP1 sequence variant does not increase risk for primary Dystonia.
- Platelet mitochondrial complex I and I+III activities do not correlate with Cerebral mitochondrial oxidative metabolism.
- Decreased striatal dopamine receptor binding in primary focal Dystonia: a D2 or D3 defect?
- Endogenous dopamine (DA) competes with the binding of a radiolabeled D(3) receptor partial agonist in vivo: A positron emission tomography study.
- Amyloid imaging of Lewy body-associated Disorders.
- [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopam...
- Vocal exercise versus voice rest following botulinum toxin injections: a randomized crossover trial.
- Assessment of Parkinson Disease manifestations.
- [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization.
- Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study.
- Gait and balance in Essential tremor: variable effects of bilateral thalamic stimulation.
- A kinematic and electromyographic analysis of turning in people with Parkinson Disease.
- Focal Dystonias of the hand and upper extremity.
- Research priorities in spasmodic dysphonia.
- Cerebral mitochondrial metabolism in early Parkinson's Disease.
- Task-specific Dystonias: a review.
- Huntington CAG repeat size does not modify onset age in familial Parkinson's Disease: the GenePD study.
- Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson Disease.
- Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson Disease.
- Effects of thalamic stimulation frequency on intention and postural Tremor.
- Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's Disease.
- Writer's cramp: questions of causation.
- Normal platelet mitochondrial complex I activity in Huntington's Disease.
- Enhancement of rigidity in Parkinson's Disease with activation.
- Perception of active and passive turning in Parkinson Disease.
- Selective defect of in vivo glycolysis in early Huntington's Disease striatum.
- The impact of litigation on neurologic research.
- Postural Tremor suppression is dependent on thalamic stimulation frequency.
- Relative risk of spread of symptoms among the focal onset primary Dystonias.
- Influence of heterozygosity for parkin mutation on onset age in familial Parkinson Disease: the GenePD study.
- [18F]FDOPA PET as an endophenotype for Parkinson's Disease linkage studies.
- Deep brain stimulation.
- [18F]FDOPA PET and clinical features in parkinsonism due to manganism.
- Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson's Disease.
- Effect of stimulation frequency on tremor suppression in Essential tremor.
- Functional changes in brain activity during acquisition and practice of movement sequences.
- Novel haplotypes in 17q21 are associated with Progressive supranuclear palsy.
- Cognitive-pharmacologic functional magnetic resonance imaging in tourette Syndrome: a pilot study.
- Atlas template images for nonhuman primate neuroimaging: baboon and macaque.
- Dysfunction of dopaminergic pathways in Dystonia.
- Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's Disease.
- Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's Disease.
- Botulinum toxin B reduces sialorrhea in parkinsonism.
- Asymmetric regional Cerebral blood flow in sedated baboons measured by positron emission tomography (PET).
- Blind men and blinking elephants.
- A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist.
- Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024).
- Parkinson's Disease and apolipoprotein E: possible association with dementia but not age at onset.
- Clinical features and comorbidity of mood fluctuations in Parkinson's Disease.
- Additive global Cerebral blood flow normalization in arterial spin labeling perfusion imaging.
- Gait-related brain activity in people with Parkinson Disease with freezing of gait.
- Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity.
- Spatial reorganization of putaminal dopamine d2-like receptors in cranial and hand Dystonia.
- The role of dopamine and dopaminergic pathways in Dystonia: insights from neuroimaging.
- HDQLIFE: the development of two new computer adaptive tests for use in Huntington Disease, Speech Difficulties, and Swallowing Difficulties.
Schools
University Of Missouri Columbia Campus
University Hosps and Clinics
Wash University Affil Hosps
Procedures Preformed
- Non-Cosmetic Chemodenervation
Conditions Treated
- Alzheimer's Disease
- Ataxia
- Cerebral Artery Thrombosis
- Cerebrovascular Disease
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Doctors Specialties
- Neurology
Accepted Insurances
Awards
- America's Top Doctors
- St. Louis Magazine: Top Doctors
- Top MD
Education
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University of Missouri-Columbia -
University of Missouri-Columbia School of Medicine
Hospital
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Barnes-Jewish Hospital -
St. Louis Children's Hospital
Drug Facts
| NPI NUMBER | 1477571156 | |
| NPPES Provider LastName | PERLMUTTER | |
| NPPES Provider FirstName | JOEL | |
| NPPES Provider ZIPCode | 631101032 | |
| NPPES Provider State | MO | |
| Specialty Description | Neurology | |
| Total Claim Count | 1374.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1477571156 |
| Last Name Of The Provider | PERLMUTTER |
| First Name Of The Provider | JOEL |
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