Professor of Radiation Oncology, University Pittsburgh
Radiation Oncology
Dr. Joel S. Greenberger, MD
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Joel Greenberger is an expert in the field of Radiation Oncology. He went to Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He has 3 awards "America's Top Doctors", "America's Top Doctors for Cancer" and "Pittsburgh Magazine". Dr. Joel S. Greenberger has written publications. He has 88 publications published with PubMed. The lastest publication is: 'Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice.'
Publications
- Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice.
- Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition.
- Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator.
- Quantitative evaluation of radiation oncologists' adaptability to lower reimbursing treatment programs.
- A mitochondrial pathway for biosynthesis of lipid mediators.
- Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2(-/-) (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039.
- The impact of ionizing radiation on placental trophoblasts.
- Radiologic Differences between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2(-/-)) Mice.
- Amelioration of Radiation-Induced Pulmonary Fibrosis by a Water-Soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350).
- Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells.
- Interceptor and Phantom Trials of EDNS at UPMC.
- ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.
- Pharmacological profiling of phosphoinositide-3-kinase inhibitors as mitigators of ionizing radiation-induced cell death.
- Conditional Radioresistance of tet-Inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines.
- Radiation therapy induces the DNA damage response in peripheral blood.
- Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.
- Nanoassembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers.
- Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling.
- l-Arginine is a Radioprotector for Hematopoietic Progenitor Cells.
- Retrospective review of patients with locally advanced esophageal cancer treated at the university of pittsburgh.
- A manganese-porphyrin complex decomposes H(2)O(2), inhibits apoptosis, and acts as a radiation mitigator in vivo.
- GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines.
- Are mitochondrial reactive oxygen species required for autophagy?
- The autophagy-inducing drug carbamazepine is a radiation protector and mitigator.
- Performance characteristics of a novel radioactive isotope detection and notification system designed for use in hospitals.
- Oxidative Lipidomics of γ-Radiation-Induced Lung Injury: Mass Spectrometric Characterization of Cardiolipin and Phosphatidylserine Peroxidation.
- Quality Assurance Analysis of a Large Multicenter Practice: Does Increased Complexity of Intensity-Modulated Radiotherapy Lead to Increased Error Frequency?
- Two Strategies for the Development of Mitochondrion-targeted Small Molecule Radiation Damage Mitigators.
- Antioxidant-Chemoprevention Diet Ameliorates Late Effects of Total-Body Irradiation and Supplements Radioprotection by MnSOD-Plasmid Liposome Administration.
- A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protec...
- Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection.
- The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from ?-Irradiation-Induced Death.
- Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death.
- Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice.
- Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy.
- Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues.
- A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator.
- Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.
- Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
- Cytochrome c/cardiolipin relations in mitochondria: a kiss of death.
- Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo.
- Bone marrow-derived stem cells and radiation response.
- Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation.
- Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells.
- Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy.
- Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene.
- PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome.
- A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation.
- Oxidative lipidomics of gamma-irradiation-induced intestinal injury.
- Oxidative lipidomics of programmed cell death.
- Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.
- Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation.
- Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.
- Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides.
- Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors.
- Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice.
- Multivariate analysis of survival, local control, and time to distant metastases in patients with unresectable non-small-cell lung carcinoma treated with 3-dimensional...
- Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-beta/Smad3 signaling.
- Photodynamic therapy induced esophageal stricture--an animal model: from mouse to pig.
- Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003.
- Head and neck cancer: meeting summary and research opportunities.
- Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients.
- Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium.
- Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese s...
- Delivery of herpes simplex virus-based vectors to stem cells.
- Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage.
- Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis.
- Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene.
- Manganese superoxide dismutase gene therapy protects against irradiation-induced cystitis.
- Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane.
- Update on results of multifield conformal radiation therapy of non-small-cell lung cancer using multileaf collimated beams.
- Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene.
- Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.
- Organ-specific Responses of Total Body Irradiated Doxycycline-inducible Manganese Superoxide Dismutase Tet/Tet Mice.
- Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies.
- Improved Hematopoiesis in GS-Nitroxide (JP4-039)-treated Mouse Long-term Bone Marrow Cultures and Radioresistance of Derived Bone Marrow Stromal Cell Lines.
- Esophageal Radioprotection by Swallowed JP4-039/F15 in Thoracic-irradiated Mice with Transgenic Lung Tumors.
- Improved Longevity of Hematopoiesis in Long-term Bone Marrow Cultures and Reduced Irradiation-induced Pulmonary Fibrosis in Toll-like Receptor-4 Deletion Recombinant-N...
- Increased Hematopoiesis in Long-term Bone Marrow Cultures and Reduced Irradiation-induced Pulmonary Fibrosis in Von Willebrand Factor Homologous Deletion Recombinant M...
- Effects of the Bifunctional Sulfoxide MMS350, a Radiation Mitigator, on Hematopoiesis in Long-term Bone Marrow Cultures and on Radioresistance of Marrow Stromal Cell L...
- Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors.
- Effects of Mouse Genotype on Bone Wound Healing and Irradiation-induced Delay of Healing.
- Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.
- Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam.
- Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from nrf2-/- homozygous deletion recombinant-negative mice.
- Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozyg...
- Effects of Thoracic Irradiation on Pulmonary Endothelial Compared to Alveolar Type-II Cells in Fibrosis-Prone C57BL/6NTac Mice.
Schools
Harvard Medical School
Doctors Specialties
- Radiation Oncology
- Radiology
Accepted Insurances
- Blue Card PPO
- Community Blue PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
- Universal American
- UPMC PPO
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Pittsburgh Magazine
Education
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Boston University Medical Center -
Harvard Medical School
Hospital
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UPMC Presbyterian Shadyside
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