Lecturer in Medicine, Northwestern University Medical School
Internal Medicine
Dr. Joanne K. Tobacman, MD
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Doctor Joanne K. Tobacman, MD practices Internal Medicine. She researched medicine at Case Western Reserve University School of Medicine. Doctor Joanne K. Tobacman, MD is a published doctor and has 70 publications published. The lastest was: 'Visual function impairments in relation to gender, age, and visual acuity in patients who undergo cataract surgery.'
Publications
- Effect of CFTR modifiers on arylsulfatase B activity in cystic fibrosis and normal human bronchial epithelial cells.
- The common food additive carrageenan and the alpha-gal epitope.
- Carrageenan Inhibits Insulin Signaling through GRB10-Mediated Decrease in Phospho(Tyr)-IRS1 and through Inflammation-Induced Increase in Phospho(Ser307)-IRS1.
- Regulation of chondroitin-4-sulfotransferase (CHST11) expression by opposing effects of arylsulfatase B on BMP4 and Wnt9A.
- Increased Expression of Colonic Wnt9A through Sp1-Mediated Transcriptional Effects involving Arylsulfatase B, Chondroitin-4-Sulfate, and Galectin-3.
- Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol.
- Differential effects of estrogen exposure on arylsulfatase B, galactose-6-sulfatase, and steroid sulfatase in rat prostate development.
- Common Food Additive Carrageenan Stimulates Wnt/ β-Catenin Signaling in Colonic Epithelium by Inhibition of Nucleoredoxin Reduction.
- Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
- Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer.
- Reduced Arylsulfatase B activity in leukocytes from cystic fibrosis patients.
- Impact of salt exposure on N-acetylgalactosamine-4-sulfatase (arylsulfatase B) activity, glycosaminoglycans, kininogen, and bradykinin.
- Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia.
- Molecular signature of kappa-carrageenan mimics chondroitin-4-sulfate and dermatan sulfate and enables interaction with arylsulfatase B.
- SPECIFIC EFFECTS OF BCL10 SERINE MUTATIONS ON PHOSPHORYLATIONS IN CANONICAL AND NON-CANONICAL PATHWAYS OF NF-KB ACTIVATION FOLLOWING CARRAGEENAN.
- Extra-lysosomal localization of arylsulfatase B in human colonic epithelium.
- Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan.
- Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations.
- Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds.
- Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent.
- B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation.
- Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate.
- ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.
- Lipopolysaccharide activates NF-kappaB by TLR4-Bcl10-dependent and independent pathways in colonic epithelial cells.
- The carrageenan diet: not recommended.
- Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.
- Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates.
- Carrageenan induces cell cycle arrest in human intestinal epithelial cells in vitro.
- Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes.
- Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells.
- Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells.
- Development, evaluation, and application of a highly sensitive microtiter plate ELISA for human Bcl10 protein.
- Does deficiency of arylsulfatase B have a role in cystic fibrosis?
- Visual acuity following cataract surgeries in relation to preoperative appropriateness ratings.
- Lactobacillus acidophilus Alleviates Platelet-Activating Factor-Induced Inflammatory Responses in Human Intestinal Epithelial Cells.
- Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTR.
- Chloroquine reduces arylsulphatase B activity and increases chondroitin-4-sulphate: implications for mechanisms of action and resistance.
- Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells.
- Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.
- Carrageenan-induced NFkappaB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10.
- Implementation of personal health records by case managers in a VAMC general medicine clinic.
- Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfat...
- Structural studies on kappa-carrageenan derived oligosaccharides.
- Steroid sulfatase activity and expression in mammary myoepithelial cells.
- Carrageenan-induced inclusions in mammary myoepithelial cells.
- Inverse relationship between density of cutaneous hair and pigmented lesion count in patients with malignant melanoma.
- Increased use of pneumococcal vaccination in a medicine clinic following initiation of a quality assessment monitor.
- Prevention of infectious diseases in ambulatory care: immunoprophylaxis and chemoprophylaxis.
- Variation in physician opinion about scheduling of return visits for common ambulatory care conditions.
- Inverse relation between density of nevi and terminal cutaneous hair. Study of male volunteer subjects and patients enrolled in a dysplastic nevus syndrome registry.
- Clinical epidemiology: further consideration.
- Diminished cutaneous hair density in dysplastic nevus syndrome.
- Mortality from multiple myeloma among North Carolina furniture workers.
- Do malignant melanoma cells arise from the hair follicle?
- Intra-abdominal carcinomatosis after prophylactic oophorectomy in ovarian-cancer-prone families.
- Use of Halon 1301 in a hospital.
- Assessment of appropriateness of cataract surgery at ten academic medical centers in 1990.
- Documentation patterns before cataract surgery at ten academic centers.
- Utilization of a personal health record in a general medicine clinic.
- Filament disassembly and loss of mammary myoepithelial cells after exposure to lambda-carrageenan.
- Visual function impairments in relation to gender, age, and visual acuity in patients who undergo cataract surgery.
- Assessment of comorbidity: a review.
- Reproducibility of measures of overuse of cataract surgery by three physician panels.
- Consumption of carrageenan and other water-soluble polymers used as food additives and incidence of mammary carcinoma.
- Review of harmful gastrointestinal effects of carrageenan in animal experiments.
- Comparison of appropriateness ratings for cataract surgery between convened and mail-only multidisciplinary panels.
- Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signalling in HepG2 cells and C57BL/6J mice.
- Increased frequency of posttransplant lymphomas in patients treated with cyclosporine, azathioprine, and prednisone.
- Increased frequency of posttransplant lymphomas in patients treated with cyclosporin, azathioprine, and prednisone.
Schools
Case Western Reserve University School of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
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Case Western Reserve University School of Medicine
Hospital
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Northwestern Memorial Hospital -
Jesse Brown Veterans Affairs Medical Center
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