Associate Professor, Pediatrics, University of Iowa College of Medicine

Pediatrics

Jessica Moreland is an expert in the field of Pediatrics. She studied medicine at Vanderbilt University School of Medicine. Jessica Moreland is also published. She has 25 publications published. The lastest publication: "Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.'

Publications

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• A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.
• NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome.
• NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults.
• Transepithelial migration of neutrophils into the lung requires TREM-1.
• Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species.
• The Accreditation Council for Graduate Medical Education proposed work hour regulations.
• Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis.
• Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.
• Electrophysiology of reactive oxygen production in signaling endosomes.
• Francisella tularensis directly interacts with the endothelium and recruits neutrophils with a blunted inflammatory phenotype.
• ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells.
• ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change.
• Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.
• Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3.
• The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels.
• Anion channels, including ClC-3, are required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration.
• Neutrophil transendothelial migration in vitro to Streptococcus pneumoniae is pneumolysin dependent.
• Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus.
• CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease.
• ROS-Containing Endosomal Compartments: Implications for Signaling.
• Pre-surgical evaluation of interrupted aortic arch with 3-dimensional reconstruction of CT images.
• Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
• TNF-alpha and IL-1 beta are not essential to the inflammatory response in LPS-induced airway disease.
• Priming of neutrophils and differentiated PLB-985 cells by pathophysiological concentrations of TNF-α is partially oxygen dependent.

Schools

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• Vanderbilt University

Doctors Specialties

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• Pediatric Critical Care Medicine
• Pediatrics

Accepted Insurances

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Education

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• Vanderbilt University
• Vanderbilt University School of Medicine

Hospital

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• University of Texas Southwestern Medical Center

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