Mallinckrodt Professor of Pathology, Beth Israel Deaconess Medical Center
Pathology
Dr. Jeffrey E. Saffitz, MD
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Dr. Jeffrey E. Saffitz is an expert in the field of Pathology. He attended Case Western Reserve University School of Medicine. Doctor Jeffrey E. Saffitz, MD is also a published doctor. He has 81 paper published. The most recent paper is: Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.
Publications
- Pathogenesis of Arrhythmogenic Cardiomyopathy.
- Arrhythmogenic Right Ventricular Cardiomyopathy Mutations Alter Shear Response without Changes in Cell-Cell Adhesion.
- Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.
- Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.
- Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic ana...
- Gap Junctions, Slow Conduction, and Ventricular Tachycardia After Myocardial Infarction.
- Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murin...
- Connexin43 Mutation Causes Heterogeneous Gap Junction Loss and Sudden Infant Death.
- 2011 Consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology.
- Gap junctions and arrhythmogenic cardiomyopathy.
- Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele.
- Arrhythmogenic cardiomyopathy: advances in diagnosis and disease pathogenesis.
- Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic: Links to Arrhythmogenic Right Ventricular Cardiomyopathy.
- Fatty acid synthase modulates homeostatic responses to myocardial stress.
- A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology...
- A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions.
- The pathobiology of arrhythmogenic cardiomyopathy.
- The role of endomyocardial biopsy in ARVC: looking beyond histology in search of new diagnostic markers.
- Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?
- Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks.
- A call to action: training pathology residents in genomics and personalized medicine.
- Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease.
- Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria.
- Mutations in desmosomal protein genes and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy.
- Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene.
- Desmosome mutations in arrhythmogenic right ventricular cardiomyopathy: important insight but only part of the picture.
- Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling.
- Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy.
- A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.
- Expanding the spectrum of arrhythmogenic cardiomyopathy.
- Gap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation.
- Sympathetic neural activity and the pathogenesis of sudden cardiac death.
- A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy.
- Protein kinase Cepsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning.
- Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic ...
- Remodeling of gap junctions in ischemic and nonischemic forms of heart disease.
- Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.
- Diminished zonula occludens-1 expression in the failing human heart.
- Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human ...
- Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes.
- Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.
- Connexins, conduction, and atrial fibrillation.
- Adhesion molecules: why they are important to the electrophysiologist.
- Douglas P. Zipes Lecture. Biology and pathobiology of cardiac connexins: from cell to bedside.
- Structural heart disease, SCN5A gene mutations, and Brugada syndrome: a complex ménage à trois.
- Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo.
- Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment.
- Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models.
- Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart.
- Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch.
- The pathology of sudden cardiac death in patients with ischemic heart disease--arrhythmology for anatomic pathologists.
- Is CaMKII a therapeutic target for ventricular rate control?
- Dependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections.
- PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
- Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load.
- Altered atrial structure begets atrial fibrillation, but how?
- Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice.
- Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.
- 3D MRI-based multicomponent FSI models for atherosclerotic plaques.
- Transmural distribution of connexins in rodent hearts.
- Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice.
- Non-ischemic left ventricular dysfunction after pediatric cardiac transplantation: treatment with plasmapheresis and OKT3.
- Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease).
- Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.
- Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart.
- Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and...
- Structural and molecular pathology of the heart in Carvajal syndrome.
- Up-regulation of connexin45 in heart failure.
- Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiol...
- Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43.
- Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning.
- Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis.
- Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice.
- c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.
- Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction.
- Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts.
- Autocrine regulation of myocyte Cx43 expression by VEGF.
- Pathologic basis of conduction disturbances: the challenge to move beyond microscopic anatomy.
- Role of the intercalated disc in cardiac propagation and arrhythmogenesis.
- Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.
Schools
Case Western Reserve University School of Medicine
Barnes Jewish Hospital
Doctors Specialties
- Pathology
Accepted Insurances
Education
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Washington University - Barnes-Jewish Hospital -
Case Western Reserve University School of Medicine
Hospital
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Beth Israel Deaconess Medical Center
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