Professor of Stem Cell and Regenerative Biology, FAS - Harvard
Neurology
Dr. Jeffrey D. Macklis, MD
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Jeffrey Macklis practices Neurology. He researched medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. Jeffrey Macklis has written publications. He has 40 publications published with PubMed. The lastest paper is: 'Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.'
Publications
- Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
- Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous neocortical-like neurons stalled at a stage equivalent to midcorticogenesis.
- Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous, neocortical-like neurons stalled at a stage equivalent to mid-corticogenesis.
- Anatomic and molecular development of corticostriatal projection neurons in mice.
- Molecular logic of neocortical projection neuron specification, development and diversity.
- Lmo4 establishes rostral motor cortex projection neuron subtype diversity.
- SnapShot: Cortical Development.
- Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.
- ROR{beta} Induces Barrel-like Neuronal Clusters in the Developing Neocortex.
- Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1Gâ¹Â³A transgenic ALS mice.
- MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons.
- Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI.
- SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development.
- Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons.
- Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development.
- Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex.
- SOX5 controls the sequential generation of distinct corticofugal neuron subtypes.
- Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.
- Identification of newborn cells by BrdU labeling and immunocytochemistry in vivo.
- Immunocytochemical analysis of neuronal differentiation.
- Neuroanatomical tracing of neuronal projections with Fluoro-Gold.
- Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation.
- Everything that glitters isn't gold: a critical review of postnatal neural precursor analyses.
- IGF-I specifically enhances axon outgrowth of corticospinal motor neurons.
- Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS.
- Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.
- Adult-born and preexisting olfactory granule neurons undergo distinct experience-dependent modifications of their olfactory responses in vivo.
- Fezl is required for the birth and specification of corticospinal motor neurons.
- Archeo-cell biology: carbon dating is not just for pots and dinosaurs.
- Large-scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice.
- Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
- Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice.
- MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions.
- The repair of complex neuronal circuitry by transplanted and endogenous precursors.
- Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.
- Selective elimination of corticogeniculate feedback abolishes the electroencephalogram dependence of primary visual cortical receptive fields and reduces their spatial...
- Induction of adult neurogenesis: molecular manipulation of neural precursors in situ.
- Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing ...
- Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Schools
Harvard Medical School
Harvard Med School Brigham and Womens Hospital
Harvard Longwood Area
Doctors Specialties
- Neurology
Accepted Insurances
Education
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Brigham and Women's Hospital -
Harvard Medical School
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