Director,Cerebrovascular/Skull Base Section; Residency Program Director
Neurosurgery
Dr. Jeffrey D. Klopfenstein, MD
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Dr. Jeffrey D. Klopfenstein practices Neurosurgery. He studied medicine at University of Arizona College of Medicine - Tucson. University of Arizona College of Medicine - Tucson is ranked 67/42 in Research/PrimaryCare. He received 2 awards: "CMS Meaningful Use Stage 1 Certification" and "Fellow (FAANS)". Jeffrey D. Klopfenstein, MD is a published doctor. He published 39 publications, including: 'Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia.
- Stem Cell Treatment After Cerebral Ischemia Regulates the Gene Expression of Apoptotic Molecules.
- Incidence and ramifications of the oculocardiac reflex during the orbitozygomatic approach: A Prospective Assessment.
- Temporal Regulation of Apoptotic and Anti-apoptotic Molecules After Middle Cerebral Artery Occlusion Followed by Reperfusion.
- Incidence of Neurosurgical Wrong Site Surgery Before and After Implementation of the Universal Protocol.
- Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.
- Chk2-mediated G2/M cell cycle arrest maintains radiation resistance in malignant meningioma cells.
- MMP-9 silencing regulates hTERT expression via ?1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells.
- Anterior Communicating Artery Aneurysm Rupture After Intravenous Thrombolysis for Acute Middle Cerebral Artery Thromboembolism.
- MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells.
- uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.
- Regulation of glioblastoma progression by cord blood stem cells is mediated by downregulation of cyclin D1.
- Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.
- Human umbilical cord blood stem cells show PDGF-D-dependent glioma cell tropism in vitro and in vivo.
- Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.
- MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.
- Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.
- Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP).
- Conversion of external ventricular drains to ventriculoperitoneal shunts after Aneurysmal subarachnoid hemorrhage: effects of site and protein/red blood cell counts on...
- Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway.
- Postoperative acute sialadenitis after skull base surgery.
- Clip reconstruction and sling wrapping of a fusiform Aneurysm: technical note.
- Incidence and pattern of direct blunt neurovascular Injury associated with trauma to the skull base.
- Retroperitoneal approach for lumbar interbody fusion with anterolateral instrumentation for treatment of spondylolisthesis and Degenerative foraminal stenosis.
- Analysis of Pain resolution after surgical resection of intramedullary spinal cord cavernous malformations.
- Use of dual transarticular screws to fixate simultaneous occipitoatlantal and atlantoaxial dislocations.
- The radical transbasal approach for resection of anterior and midline skull base lesions.
- Indications for surgical fusion of the Cervical and lumbar motion segment.
- Middle Cerebral artery stenosis: endovascular and surgical options.
- Preserving olfactory function in anterior craniofacial surgery through cribriform plate osteotomy applied in selected patients.
- Exposure of midline Cranial base without a facial incision through a combined craniofacial-transfacial procedure.
- Surgical management of cervical disc Disease: from no fusion to fusion and back again.
- Treatment of basilar invagination associated with Chiari I malformations in the pediatric population: Cervical reduction and posterior occipitoCervical fusion.
- Intraoperative Iso-C C-arm navigation in craniospinal surgery: the first 60 cases.
- Comparison of routine and selective use of intraoperative angiography during Aneurysm surgery: a prospective assessment.
- Comparison of rapid and gradual weaning from external ventricular drainage in patients with Aneurysmal subarachnoid hemorrhage: a prospective randomized trial.
- Scalp burns from halo pins following magnetic resonance imaging. Case illustration.
- Ectopic intracavernous sinus adrenocorticotropic hormone-secreting microadenoma: could this be a common cause of failed transsphenoidal surgery in Cushing Disease? Cas...
Schools
University of Arizona
Procedures Preformed
- Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Dural Repair or Other Spinal Spinal Cord Repair
- Epidural Block, Facet Blocks
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Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Aneurysm
- Brain Cancer
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FAANS)
Education
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Barrow Neurological Institute -
University of Arizona College of Medicine - Tucson
Drug Facts
| NPI NUMBER | 1578508354 | |
| NPPES Provider LastName | KLOPFENSTEIN | |
| NPPES Provider FirstName | JEFFREY | |
| NPPES Provider ZIPCode | 616052530 | |
| NPPES Provider State | IL | |
| Specialty Description | Neurosurgery | |
| Total Claim Count | 132.0 | |
| Distinct Opioid Count | 2.0 | |
| Opioid Claim Count | 56.0 | |
| Percent Opioid Claims | 42.42 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1578508354 |
| Last Name Of The Provider | KLOPFENSTEIN |
| First Name Of The Provider | JEFFREY |
| View All |
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