Professor, Pediatrics, UCSF School of Medicine
Pediatrics
Dr. Jeff R. Fineman, MD
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Jeff Fineman practices Pediatrics. He studied medicine at NYU School of Medicine. Jeff Fineman is a published MD as well. He has 101 publications published. The latest was: Role of the endothelium in placental dysfunction after fetal cardiac bypass.
Publications
- B-type natriuretic peptide: prognostic marker in congenital diaphragmatic hernia.
- Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs.
- Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs.
- Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure.
- Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension.
- Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension.
- Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes.
- Endothelin-1 in congenital heart disease.
- Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter.
- Inhaled nitric oxide induced NOS inhibition and rebound pulmonary hypertension: a role for superoxide and peroxynitrite in the intact lamb.
- Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs.
- Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker.
- Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo.
- Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.
- BNP for pediatrics--not quite ready for primetime.
- Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension.
- Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
- Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide.
- Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo.
- Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
- The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow.
- Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow.
- Pediatric pulmonary hypertension: Roles of endothelin-1 and nitric oxide.
- Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.
- Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs.
- B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery.
- B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery.
- Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.
- Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection.
- Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.
- Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia.
- Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow.
- Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension.
- Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.
- Usefulness of various plasma biomarkers for diagnosis of heart failure in children with single ventricle physiology.
- Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs.
- Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow.
- Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease.
- Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow.
- Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1.
- Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb.
- Emergence of smooth muscle cell endothelin B-mediated vasoconstriction in lambs with experimental congenital heart disease and increased pulmonary blood flow.
- Pharmacologic therapy for persistent pulmonary hypertension of the newborn: as "poly" as the disease itself.
- Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life.
- Treatment of rebound and chronic pulmonary hypertension with oral sildenafil in an infant with congenital diaphragmatic hernia.
- Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site di...
- Perinatal changes in superoxide generation in the ovine lung: Alterations associated with increased pulmonary blood flow.
- Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide.
- Congenital diaphragmatic hernia: endothelin-1, pulmonary hypertension, and disease severity.
- Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease.
- Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
- Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease.
- Pediatric pulmonary arterial hypertension: current and emerging therapeutic options.
- Advances in the management of pediatric pulmonary hypertension.
- Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb.
- Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure.
- Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha: a positive-feedback loop promoting pulmonary vascular remodeling.
- In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs.
- Developmental effects of endothelin-1 on the pulmonary circulation in sheep.
- Hyperoxia and alkalosis produce pulmonary vasodilation independent of endothelium-derived nitric oxide in newborn lambs.
- Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
- Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1.
- Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow.
- Altered endothelial function in lambs with pulmonary hypertension and acute lung injury.
- Inhaled nitric oxide, oxygen, and alkalosis: dose-response interactions in a lamb model of pulmonary hypertension.
- Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow.
- Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension.
- Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1.
- sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow.
- Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects.
- Effects of vasoactive drugs on thromboxane A2 mimetic-induced pulmonary hypertension in newborn lambs.
- N omega-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs.
- EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
- K+ channel pulmonary vasodilation in fetal lambs: role of endothelium-derived nitric oxide.
- EDRF inhibition augments pulmonary hypertension in intact newborn lambs.
- In vivo attenuation of endothelium-dependent pulmonary vasodilation by methylene blue.
- Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
- Regulation of pulmonary vascular tone in the perinatal period.
- Endothelin-1 does not mediate acute hypoxic pulmonary vasoconstriction in the intact newborn lamb.
- Diethylamine/nitric oxide (NO) adduct, an NO donor, produces potent pulmonary and systemic vasodilation in intact newborn lambs.
- Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.
- Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb.
- Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
- Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow.
- Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
- Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension.
- Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension.
- Role of the endothelium in placental dysfunction after fetal cardiac bypass.
- Increased pulmonary blood flow alters the molecular regulation of vascular reactivity in the lamb.
- L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
- Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects.
- The pathophysiology of pulmonary hypertension in congenital heart disease.
- Selective pulmonary vasodilation with ATP-MgCl2 during pulmonary hypertension in lambs.
- M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs.
- Inhaled nitric oxide enhances oxygenation but not survival in infants with alveolar capillary dysplasia.
- HA1004, an intracellular calcium antagonist, selectively attenuates pulmonary hypertension in newborn lambs.
Schools
New York University
Doctors Specialties
- Pediatric Critical Care Medicine
- Pediatrics
Accepted Insurances
Education
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NYU School of Medicine
Hospital
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UCSF Medical Center
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