Physician

Infectious Disease

James Larrick works in the field of Infectious Disease. James Larrick is a published MD. He has 101 papers published. The most current publication "Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation."

Publications

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• Telomerase Redux: ready for prime time?
• Systemic factors mediate reversible age-associated brain dysfunction.
• Paradoxical effects of antioxidants on cancer.
• Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD(+) Levels.
• Sleep facilitates clearance of metabolites from the brain: Glymphatic function in aging and neurodegenerative diseases.
• Trade-offs between Anti-aging Dietary Supplementation and Exercise.
• Rejuvenation of aging hearts.
• Willem 'pim' stemmer 1957-2013.
• Dietary modification of the microbiome affects risk for cardiovascular disease.
• Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor.
• Rejuvenation of adult stem cells: is age-associated dysfunction epigenetic?
• The DNA methylome as a biomarker for epigenetic instability and human aging.
• FGF21 is a promising dietary restriction mimetic.
• Ectopic expression of telomerase safely increases health span and life span.
• Dissecting Mammalian target of rapamycin to promote longevity.
• Overcoming the aging systemic milieu to restore neural stem cell function.
• Reversing age-related decline in working memory.
• Rapamycin as an antiaging therapeutic?: targeting Mammalian target of rapamycin to treat hutchinson-gilford progeria and neurodegenerative diseases.
• Medical implications of basic science: protein homeostasis as a clinical target for increased longevity?
• Master switch of mitochondrial biogenesis: a clinical target for health span enhancement?
• Applied Healthspan engineering.
• Targeted in vivo extracellular matrix formation promotes neovascularization in a rodent model of myocardial infarction.
• Antibody targeting of stem cells to infarcted myocardium.
• CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity, and preliminary toxicity study.
• Synthesis and cytotoxicity of a biotinylated CC-1065 analogue.
• Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug.
• Recombinant antibodies.
• Human neutrophil granule cationic protein CAP37 is a specific macrophage chemotaxin that shares homology with inflammatory proteinases.
• In vitro immunization of human B lymphocytes. MAPPing of lymphokine specific mRNA and the effect of recombinant factors.
• Complementary DNA sequence of rabbit CAP18--a unique lipopolysaccharide binding protein.
• Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes.
• Primer design for the cloning of immunoglobulin heavy-chain leader-variable regions from mouse hybridoma cells using the PCR.
• Tumor necrosis factor induces activation of mitochondrial succinate dehydrogenase.
• Soluble suppressive molecule released by human T lymphocytes induced by heat-inactivated allostimulator cells in the presence of cyclosporine.
• Human monoclonal antibodies specific for capsular polysaccharides of Klebsiella recognize clusters of multiple serotypes.
• The methyl xanthine hypothesis: does tea consumption by Tibetan natives blunt the effects of high altitude?
• Rabbit CAP18 derived peptides inhibit gram negative and gram positive bacteria.
• Endotoxin-binding synthetic peptides with endotoxin-neutralizing, antibacterial and anticoagulant activities.
• Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.
• Smoking and neurogenerative diseases.
• Doxorubicin and DNA minor groove-binding oligopeptide conjugates as anticancer agents.
• Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.
• Inhibition of apoptosis as a mechanism of tumor promotion.
• Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide.
• Antimicrobial activity of rabbit CAP18-derived peptides.
• Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.
• A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity.
• Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U9...
• Nicotine inhibition of apoptosis suggests a role in tumor promotion.
• Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-alpha, and IL-1 beta.
• Allotypic dependency of the specificity and avidity of human monoclonal IgM rheumatoid factors derived from rheumatoid synovial cells.
• Structure and functions of endotoxin-binding peptides derived from CAP18.
• Isolation and characterization of a chimpanzee monoclonal antibody to the G glycoprotein of human respiratory syncytial virus.
• Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-k...
• Identification of functional and structural amino-acid residues by parsimonious mutagenesis.
• Structural, functional analysis and localization of the human CAP18 gene.
• A derivative of cationic antimicrobial protein attenuates lung injury by suppressing cell adhesion.
• Antimicrobial action of rabbit leukocyte CAP18(106-137).
• Ligation of MHC class I induces apoptosis in human pre-B cell lines, in promyelocytic cell lines and in CD40-stimulated mature B cells.
• Testing the power of belief.
• Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis.
• Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activ...
• Meeting report from the ''Therapeutic Antibody Technology 95'' meeting--not just ''another recombinant antibody meeting''.
• Anti-microbial activity of human CAP18 peptides.
• Green fluorescent protein: untapped potential in immunotechnology.
• Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS.
• Therapeutic antibody technology 97.
• Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus.
• Production of antibodies in transgenic plants.
• Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model.
• Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.
• Molecular mechanisms of interaction of rabbit CAP18 with outer membranes of gram-negative bacteria.
• Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.
• Antibody engineering at the millennium.
• Mechanisms of action of rabbit CAP18 on monolayers and liposomes made from endotoxins or phospholipids.
• Interaction of CAP18-derived peptides with membranes made from endotoxins or phospholipids.
• Producing proteins in transgenic plants and animals.
• Production of secretory IgA antibodies in plants.
• Hybrid IgA2/IgG1 antibodies with tailor-made effector functions.
• Co-migration and internalization of transferrin and its receptor on K562 cells.
• Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor.
• Production of human monoclonal antibody in mouse ascites.
• Characterization of human hybridomas secreting antibody to tetanus toxoid.
• Protective effect of snake venom antibodies in sera of previous snake bite victims.
• Digital and palmar dermatoglyphic patterns among natives of extreme northwest Nepal.
• Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease?
• Studies of endemic cretinism in Papua New Guinea: digital and palmar dermatoglyphic patterns.
• Gm and Inv (Km) studies of Melanesian people on the Huon Peninsula in Northeast Papua New Guinea: polymorphism for a Gm1,5,10,11,13,14,17,21,26 Haplotype.
• Snake venom antibodies in Ecuadorian Indians.
• Should mild hypertension be treated with drugs?
• Infectious disease patterns in the Waorani, an isolated Amerindian population.
• Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.
• Hyperimmunoglobulinemia E in the Waorani, an isolated Amerindian population.
• Antibody engineering by parsimonious mutagenesis.
• Variable region sequence modulates periplasmic export of a single-chain Fv antibody fragment in Escherichia coli.
• The solution structure of the active domain of CAP18--a lipopolysaccharide binding protein from rabbit leukocytes.
• PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR.
• Transferrin receptors on leukaemic cells.
• Transferrin receptors on human B and T lymphoblastoid cell lines.
• Thymus Maintenance and Regeneration by Specific Molecular Factors.

Doctors Specialties

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• Internal Medicine
• Infectious Disease

Accepted Insurances

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