Associate Professor of Medicine, University VA School of Medicine
Radiation Oncology
Dr. James M. Larner, MD
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James M. Larner, MD works in the field of Radiation Oncology. He graduated from Albert Einstein College of Medicine at Jacobi Medical Center. He received 3 awards: "America's Top Doctors", "CMS Meaningful Use Stage 1 Certification" and "America's Top Doctors for Cancer". James M. Larner, MD is a published MD. He has 100 papers published. The most current publication "The radiation-induced S-phase checkpoint is independent of CDKN1A." James Larner accepts Medicare payments and is listed with Medicare.gov.
Publications
- Brainstem metastases treated with stereotactic radiosurgery: safety, efficacy, and dose response.
- Leukoencephalopathy After Stereotactic Radiosurgery for Brain Metastases.
- Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.
- Pulmonary toxicity in a rabbit model of stereotactic lung radiation therapy: Efficacy of a radioprotector.
- Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells.
- T-type Ca2+ Channel Inhibition Induces p53 Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells.
- MicroRNA-34a promotes DNA damage and mitotic catastrophe.
- MR-guided focused ultrasound surgery, present and future.
- Special treatment issues in non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical p...
- Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
- Subependymal seeding of low-grade oligodendroglial neoplasms: a case series.
- RapidArc patient specific mechanical delivery accuracy under extreme mechanical limits using linac log files.
- Helical Tomotherapy Planning for Lung Cancer Based on Ventilation Magnetic Resonance Imaging.
- Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT).
- Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapy.
- Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy.
- Helical tomotherapy-based STAT RT: Dosimetric evaluation for clinical implementation of a rapid radiation palliation program.
- Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathing.
- Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI.
- A rabbit irradiation platform for outcome assessment of lung stereotactic radiosurgery.
- Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
- PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.
- Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis.
- Semiconductor nanoparticles as energy mediators for photosensitizer-enhanced radiotherapy.
- Is daily CT image guidance necessary for nasal cavity and nasopharyngeal radiotherapy: an investigation based on helical tomotherapy.
- Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance ima...
- Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy f...
- Protein phosphatase-1alpha regulates centrosome splitting through Nek2.
- Helical TomoTherapy in the treatment of central nervous system metastasis.
- Dose as a function of liver volume and planning target volume in helical tomotherapy, intensity-modulated radiation therapy-based stereotactic body radiation therapy f...
- The Ki-67 labeling index as a prognostic factor in Grade II oligoastrocytomas.
- Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation.
- ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.
- Helical tomotherapy simultaneous integrated boost provides a dosimetric advantage in the treatment of primary intracranial tumors.
- Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy.
- Evaluation of thoracic spinal cord motion using dynamic MRI.
- Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).
- ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes.
- A motion phantom study on helical tomotherapy: the dosimetric impacts of delivery technique and motion.
- A dosimetric comparison of non-coplanar IMRT versus Helical Tomotherapy for nasal cavity and paranasal sinus cancer.
- Effect of oral nutritional supplementation on weight loss and percutaneous endoscopic gastrostomy tube rates in patients treated with radiotherapy for oropharyngeal ca...
- Gamma Knife radiosurgery to the surgical cavity following resection of brain metastases.
- The implication of non-cyclic intrafractional longitudinal motion in SBRT by TomoTherapy.
- Tumor cell survival dependence on helical tomotherapy, continuous arc and segmented dose delivery.
- Radiosurgery in the treatment of spinal metastases: tumor control, survival, and quality of life after helical tomotherapy.
- Feasibility of non-coplanar tomotherapy for lung cancer stereotactic body radiation therapy.
- Tumor cell apoptosis induced by nanoparticle conjugate in combination with radiation therapy.
- Improving the radiosensitivity of radioresistant and hypoxic glioblastoma.
- Histone H1 and H3 dephosphorylation are differentially regulated by radiation-induced signal transduction pathways.
- Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM.
- Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.
- The role of preoperative adjuvant treatment in the management of esthesioneuroblastoma: the University of Virginia experience.
- A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells.
- Radiation effects on DNA synthesis in a defined chromosomal replicon.
- S phase damage sensing checkpoints in mammalian cells.
- A phase I-II trial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme.
- Radiotherapy for basaloid squamous cell carcinoma of the head and neck.
- Extradural failure in glioblastoma multiforme: MRI demonstration.
- A phase 1-2 trial of superselective carboplatin, low-dose infusional 5-fluorouracil and concurrent radiation for high-grade gliomas.
- Definitive radiotherapy for T1 and T2 squamous cell carcinoma of the tonsil.
- A model phosphatase 2C --> phosphatase 1 activation cascade via dual control of inhibitor-1 (INH-1) and DARPP-32 dephosphorylation by two inositol glycan putative insu...
- Extracranial absorbed doses with Gamma Knife radiosurgery.
- Glomus jugulare tumors. Long-term control by radiation therapy.
- Phase I/II trial of superselective arterial 5-FU infusion with concomitant external beam radiation for patients with either anaplastic astrocytoma or glioblastoma mult...
- The radiation-induced S-phase checkpoint is independent of CDKN1A.
- Cloning and characterization of Chinese hamster p53 cDNA.
- Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.
- Osteoradionecrosis mimicking metastatic epidural spinal cord compression.
- Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma.
- Esthesioneuroblastoma. Long-term outcome and patterns of failure--the University of Virginia experience.
- Mechanisms of aluminum fluoride- and insulin-stimulated p33 mRNA accumulation in rat hepatoma cells: involvement of a G protein and kinase action and demonstration of ...
- Insulin and the stimulation of glycogen synthesis. The road from glycogen structure to glycogen synthase to cyclic AMP-dependent protein kinase to insulin mediators.
- A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.
- In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues.
- Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes.
- The dosimetric consequences of weighted fields using the same isocenter in radiosurgery.
- Desmoplastic fibroma: a role for radiotherapy?
- The tumor suppressor p53 can reduce stable transfection in the presence of irradiation.
- The generation of inositolglycan mediators from rat liver plasma membranes: the role of guanine nucleotide binding proteins.
- Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: an effect of insulin on glycogen synthase mRNA sta...
- Third ventricular lesion masquerading as suprasellar disease.
- Significance of CT-scan-detected seminal vesicle enlargement in prostate cancer. A pilot study.
- Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor.
- chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialys...
- Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozo...
- Identification and characterization of chiroinositol-containing phospholipids from bovine liver.
- Insulin-signaling mechanisms. Lessons from the old testament of glycogen metabolism and the new testament of molecular biology.
- Insulin mediators and the control of pyruvate dehydrogenase complex.
- Insulin and a putative insulin metabolic mediator fraction from liver and muscle stimulate p33 messenger ribonucleic acid accumulation by apparently different mechanisms.
- Insulin mediators: structure and formation.
- Contrasting interactions between phorbol ester and insulin on the regulation of glycogen synthase activity and p33 mRNA accumulation in rat hepatoma cells.
- Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.
- Selective transcription of an insulin-regulated gene in nuclear extracts of rat hepatoma cells.
- Urinary myo-inositol-to-chiro-inositol ratios and insulin resistance.
- Circulating factors and insulin resistance. II. The action of the novel myo-inositol cyclic 1,2-inositol phosphate phosphoglycan insulin antagonist from human plasma i...
- Characterization of a nucleotide stimulated aspartic proteinase in rat liver plasma membranes.
- Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-de...
- Phosphoinositol glycan derived mediators and insulin resistance. Prospects for diagnosis and therapy.
- Insulin mediator stimulation of pyruvate dehydrogenase phosphatases.
Schools
Virginia Commonwealth University School Of Medicine
Albert Einstein College Of Med
Cardeza Foundation
Thomas Jefferson University Hospital
Procedures Preformed
- Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
Doctors Specialties
- Hematology
- Radiation Oncology
Accepted Insurances
Awards
- America's Top Doctors
- CMS Meaningful Use Stage 1 Certification
- America's Top Doctors for Cancer
Education
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Thomas Jefferson University -
Albert Einstein College of Medicine at Jacobi Medical Center -
Albany Medical Center -
University of Virginia School of Medicine
Hospital
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University of Virginia Medical Center
Drug Facts
| NPI NUMBER | 1205979143 | |
| NPPES Provider LastName | LARNER | |
| NPPES Provider FirstName | JAMES | |
| NPPES Provider ZIPCode | 22903 | |
| NPPES Provider State | VA | |
| Specialty Description | Radiation Oncology | |
| Total Claim Count | 20.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1205979143 |
| Last Name Of The Provider | LARNER |
| First Name Of The Provider | JAMES |
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