Adjunct Professor in Pathology, Northwestern University Medical School
Pathology
Dr. James L. Madara, MD
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James Madara works in the field of Pathology. He went to medical school at Drexel University College of Medicine. He over the years received 2 awards: "Elected Member" and "Whos Who in Medicine and Healthcare". Dr. James L. Madara is also published. He has 101 publications published. The lastest publication: "Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization.'
Publications
- About leadership.
- Our new president--Gail A. Hecht, MD, MS.
- Evidence-based appointment and promotion of academic faculty at the University of Chicago.
- Promoting an environment of professionalism: the University of Chicago "Roadmap".
- Flagellin-induced tolerance of the Toll-like receptor 5 signaling pathway in polarized intestinal epithelial cells.
- Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts.
- Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor.
- Maintenance of certification for pathologists: what we know so far.
- Role of the urban academic medical center in US health care.
- Acute induction of human IL-8 production by intestinal epithelium triggers neutrophil infiltration without mucosal injury.
- Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells.
- Building an intestine--architectural contributions of commensal bacteria.
- RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin.
- Bacterial activation of beta-catenin signaling in human epithelia.
- Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia.
- Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response.
- Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
- Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella.
- Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.
- Cdc42 and Rac1 regulate late events in Salmonella typhimurium-induced interleukin-8 secretion from polarized epithelial cells.
- Intestinal epithelial pathobiology: past, present and future.
- Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.
- The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation.
- Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis.
- Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.
- The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells.
- Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins.
- The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47.
- CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia.
- Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
- Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules.
- Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events.
- Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6.
- Periscope, up! Monitoring microbes in the intestine.
- Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.
- Negative regulation of epithelium-neutrophil interactions via activation of CD44.
- Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.
- Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response.
- Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes.
- Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.
- Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells.
- Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport.
- Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination.
- Lipoxin-stable analogs: potential therapeutic downregulators of intestinal inflammation.
- Modulation of tight junctional permeability.
- Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells.
- Polarity of A2b adenosine receptor expression determines characteristics of receptor desensitization.
- Tight junctions are membrane microdomains.
- Adhesion molecules expressed on homing lymphocytes in model intestinal epithelia.
- Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway.
- Presentation of the Julius M. Friedenwald medal to Jerry S. Trier, M.D.
- LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation.
- Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization.
- hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions.
- Migration of intestinal intraepithelial lymphocytes into a polarized epithelial monolayer.
- Distinct Ca2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells.
- Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia.
- Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.
- Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced...
- Apical secretion of a pathogen-elicited epithelial chemoattractant activity in response to surface colonization of intestinal epithelia by Salmonella typhimurium.
- Regulation of the movement of solutes across tight junctions.
- Review article: Pathobiology of neutrophil interactions with intestinal epithelia.
- Neutrophil migration across model intestinal epithelia: monolayer disruption and subsequent events in epithelial repair.
- Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation.
- The chameleon within: improving antigen delivery.
- Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3.
- Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.
- Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia.
- Unmasking of intestinal epithelial lateral membrane beta1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yer...
- Intestinal epithelial restitution. Involvement of specific laminin isoforms and integrin laminin receptors in wound closure of a transformed model epithelium.
- Na:K:2Cl cotransporter (NKCC) of intestinal epithelial cells. Surface expression in response to cAMP.
- Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils.
- IFN-gamma modulates CD1d surface expression on intestinal epithelia.
- Intestinal epithelial cytoskeleton selectively constrains lumen-to-tissue migration of neutrophils.
- Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global trans...
- Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion.
- CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia.
- New insights on molecular pathways utilized by salmonella species in cell binding.
- Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect.
- Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils.
- Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.
- Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils.
- Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
- Transcytosis of cholera toxin subunits across model human intestinal epithelia.
- Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
- Physiological regulation of intestinal epithelial tight junctions as a consequence of Na(+)-coupled nutrient transport.
- Transepithelial signaling to neutrophils by salmonellae: a novel virulence mechanism for gastroenteritis.
- Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions.
- The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia.
- Human eosinophils migrate across an intestinal epithelium in response to platelet-activating factor.
- Intestinal epithelia (T84) possess basolateral ligands for CD11b/CD18-mediated neutrophil adherence.
- Assessment of inflammatory events in epithelial permeability: a rapid screening method using fluorescein dextrans.
- Modulation of intercellular junctions of epithelia by scatter factor (hepatocyte growth factor).
- IL-4 directly modulates function of a model human intestinal epithelium.
- Interactions of neutrophils with epithelial cells: lessons from the intestine.
- Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells.
- Reconstitution of cultured intestinal epithelial monolayers with a mucosal-derived T lymphocyte cell line. Modulation of epithelial phenotype dependent on lymphocyte-b...
- Sodium-glucose cotransport and epithelial permeability.
- Na-K-2Cl cotransport in intestinal epithelial cells. Influence of chloride efflux and F-actin on regulation of cotransporter activity and bumetanide binding.
- Enterocytes adhere preferentially to collagen IV in a differentially regulated divalent cation-dependent manner.
Schools
Hahnemann Medical College
New England Deaconess Hospital
Peter Bent Brigham Hospital Brigham and Women39s Hospital
American Medical Association AMA Executive Vice President
Doctors Specialties
- Pathology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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Brigham and Women's Hospital -
Beth Israel Deaconess Medical Center -
Drexel University College of Medicine
Hospital
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Northwestern Memorial Hospital
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